Ruth H Paulssen


Professor, dr. philos.

Stillingsbeskrivelse

Forskningsgruppeleder  Klinisk Bioinformatikk

Leder for Genomics Support Centre Tromsø (GSCT)


  • Christopher Graham Fenton, Mithlesh Kumar Ray, Wei Meng, Ruth H Paulssen :
    Methylation-Regulated Long Non-Coding RNA Expression in Ulcerative Colitis
    International Journal of Molecular Sciences 2023 ARKIV / DOI
  • Wei Meng, Kay-Martin Johnsen, Christopher Graham Fenton, Jon Florholmen, Ruth H Paulssen :
    Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis
    Functional & Integrative Genomics 2023 ARKIV / DOI
  • Alicia Villatoro, Vincent Cuminetti, Aurora Bernal Mera, Carlos Torroja, Itziar Cossío, Alberto Benguría m.fl.:
    Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
    Nature Communications 2023 ARKIV / DOI
  • Sanda Krum-Hansen, Karina Standahl Olsen, Endre Anderssen, Jan Ole Frantzen, Eiliv Lund, Ruth H Paulssen :
    Associations of breast cancer related exposures and gene expression profiles in normal breast tissue - The Norwegian Women and Cancer normal breast tissue study
    Cancer Reports 2023 ARKIV / DOI
  • Mithlesh Kumar Ray, Christopher Graham Fenton, Ruth H Paulssen :
    Novel long non-coding RNAs of relevance for ulcerative colitis pathogenesis
    Non-coding RNA Research 2022 ARKIV / DOI
  • Amrinder Singh, Christopher Graham Fenton, Endre Anderssen, Ruth H Paulssen :
    Identifying predictive signalling networks for Vedolizumab response in ulcerative colitis
    International Journal of Colorectal Disease 11. mai 2022 ARKIV / DOI
  • Amrinder Singh, Endre Anderssen, Christopher Graham Fenton, Ruth H Paulssen :
    Identifying anti-TNF response biomarkers in ulcerative colitis using a diffusion-based signalling model
    Bioinformatics Advances 2021 ARKIV / DOI
  • Eva-Stina Isabella Edholm, Christopher Graham Fenton, Stanislas Mondot, Ruth H Paulssen, Marie-Paule Lefranc, Pierre Boudinot m.fl.:
    Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids
    Frontiers in Immunology 28. oktober 2021 ARKIV / DOI
  • Hagar Taman, Christopher Graham Fenton, Endre Anderssen, Jon Florholmen, Ruth H Paulssen :
    DNA hypo-methylation facilitates anti-inflammatory responses in severe ulcerative colitis
    PLOS ONE 2021 ARKIV / DOI
  • Christopher Graham Fenton, Hagar Taman, Jon Florholmen, Sveinung Sørbye, Ruth H Paulssen :
    Transcriptional signatures that define ulcerative colitis in remission
    Inflammatory Bowel Diseases 2020 ARKIV / DOI
  • Mona Dixon Gundersen, Rasmus Goll, Christopher Graham Fenton, Endre Anderssen, Sveinung Wergeland Sørbye, Jon Florholmen m.fl.:
    Fibrosis Mediators in the Colonic Mucosa of Acute and Healed Ulcerative Colitis
    Clinical and Translational Gastroenterology 2019 ARKIV / DOI
  • Hagar Mohamed Taman, Christopher Graham Fenton, Inga Viktoria Hensel, Endre Anderssen, Jon Florholmen, Ruth H Paulssen :
    Transcriptomic Landscape of Treatment-Naïve Ulcerative Colitis
    Journal of Crohn's and Colitis 2018 ARKIV / DOI
  • Hagar Taman, Christopher Graham Fenton, Inga Viktoria Hensel, Endre Anderssen, Jon Florholmen, Ruth H Paulssen :
    Genome-Wide DNA Methylation in Treatment-Naïve Ulcerative Colitis
    Journal - Crohn's and Colitis Foundation of Canada 2018 ARKIV / DOI
  • Yvonne Pasing, Christopher Graham Fenton, Rolf Jorde, Ruth H Paulssen :
    Changes in the human transcriptome upon vitamin D supplementation
    Journal of Steroid Biochemistry and Molecular Biology 2017 ARKIV / DOI
  • Armin Schniers, Endre Anderssen, Christopher Graham Fenton, Rasmus Goll, Yvonne Pasing, Ruth H Paulssen m.fl.:
    The Proteome of Ulcerative Colitis in Colon Biopsies from Adults - Optimized Sample Preparation and Comparison with Healthy Controls
    PROTEOMICS - Clinical Applications 2017 DOI
  • Åse Florholmen-Kjær, Rasmus Goll, Ole-Martin Fuskevåg, Ingvild Nygård, Ruth H Paulssen, Arthur Revhaug m.fl.:
    The impact of partial hepatectomy on oxidative state in the liver remnant - An in vivo swine model
    Redox Biology 2016 ARKIV / DOI
  • Kenneth Lønvik, Sveinung Wergeland Sørbye, Marit Nina Nilsen, Ruth H Paulssen :
    Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: Co-expression of Drosha and miR-126 predicts poor survival
    BMC Clinical Pathology 11. desember 2014 FULLTEKST / ARKIV / DOI
  • Karina Standahl Olsen, Christopher Graham Fenton, Livar Frøyland, Marit Waaseth, Ruth H Paulssen, Eiliv Lund :
    Plasma Fatty Acid Ratios Affect Blood Gene Expression Profiles - A Cross-Sectional Study of the Norwegian Women and Cancer Post-Genome Cohort
    PLOS ONE 2013 ARKIV / DOI
  • Inigo Zubiavrre Martinez, Christopher Graham Fenton, Hagar Mohamed Taman, ingvild Pettersen, Turid Hellevik, Ruth H Paulssen :
    Tumorigenic responses of Cancer-Associated Fibroblasts after ablative radiotherapy: A transcriptome-profiling study
    Journal of Cancer Therapy 2013 DOI
  • Turid Hellevik, ingvild Pettersen, Vivian Berg, Jan-Olof Winberg, Bjørn Torvald Greve Moe, Kristian Bartnes m.fl.:
    Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced
    Radiation Oncology 2012 ARKIV / DOI
  • Vasilis Sitras, Christopher Graham Fenton, Ruth H Paulssen, Åse Vårtun, Ganesh Acharya :
    Differences in Gene Expression between First and Third Trimester Human Placenta: A Microarray Study
    PLOS ONE 2012 ARKIV / DOI
  • vanessa Dumeaux, Karina Standahl Olsen, G Nuel, Ruth H Paulssen, Anne-Lise Børresen-Dale, Eiliv Lund :
    Deciphering Normal Blood Gene Expression Variation-The NOWAC Postgenome Study
    PLoS Genetics 2010 ARKIV / DOI
  • Kristin Snipstad, Christopher Graham Fenton, Jørn Kjæve, Guanglin Cui, Endre Anderssen, Ruth H Paulssen :
    New specific molecular targets for radio-chemotherapy of rectal cancer
    Molecular Oncology 2010 DOI
  • hege lynum Pedersen, erik Hjerde, steinar Paulsen, Hilde Hansen, Lotte Olsen, Sunniva Katharina Thode m.fl.:
    Global responses of Aliivibrio salmonicida to hydrogen peroxide as revealed by microarray analysis
    Marine Genomics 2010 DOI
  • Anne Ørbo, Bjørn Torvald Greve Moe, Halvor Grønaas, Ruth H Paulssen :
    Early effects of high concentrations of progesterone and Mifepristone. A gene expression study of endometrial cancer cells (ishikawa)
    Journal of Steroid Biochemistry and Molecular Biology 2009 DOI
  • Vasilis Sitras, Ruth H Paulssen, Jørn Leirvik, Åse VÅrtun, Ganesh Acharya :
    Placental Gene Expression Profile in Intrauterine Growth Restriction Due to Placental Insufficiency
    Reproductive Sciences 2009 DOI
  • Vasilis Sitras, Ruth H Paulssen, Halvor Grønaas, Jørn Leirvik, Tor-Arne Hanssen, Åse VÅrtun m.fl.:
    Differential Placental Gene Expression in Severe Preeclampsia
    Placenta 2009 DOI
  • Ruth H Paulssen, Bjørn Moe, Halvor Grønaas, Anne Ørbo :
    Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone
    Steroids 2008 DOI
  • Ruth H Paulssen, Bjørn Moe, Halvor Grønaas, Anne Ørbo :
    Gene expression in endometrial cancer cells (Ishikawa)after short time high exposure to progesterone
    Steroids 2008 DOI
  • Vasilis Sitras, Ruth H Paulssen, Halvor Grønaas, Åse VÅrtun, Ganesh Acharya :
    Gene expression profile in labouring and non-labouring human placenta near term
    Molecular human reproduction 2008 DOI
  • Alicia Elena Villatoro Gonzalez, Vincent Cuminetti, Aurora Bernal Mera, Carlos Torroja, Itziar Cossío, Alberto Benguría m.fl.:
    Author Correction: Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation (Nature Communications, (2023), 14, 1, (12), 10.1038/s41467-022-35700-9)
    Nature Communications 2023 DOI
  • Mithlesh Kumar Ray, Christopher Graham Fenton, Ruth H Paulssen :
    Novel long-coding RNAs of relevance for ulcerative colitis pathogenesis
    2022 ARKIV
  • Wei Meng, Mithlesh Kumar Ray, Christopher Graham Fenton, Endre Anderssen, Ruth H Paulssen :
    Analysis of methylation data with imputation with blocks (MethylBlocks)
    2022 ARKIV
  • Karina Standahl Olsen, Sanda Krum-Hansen, Endre Anderssen, Frantzen Jan-Ole, Eiliv Lund, Ruth H Paulssen :
    Associations of breast cancer related exposures and gene expression profiles in normal breast tissue
    2021
  • Christopher Graham Fenton, Hagar Taman, Jon Florholmen, Ruth H Paulssen :
    Transcriptional profiling of ulcerative colitis in remission
    2019
  • Christopher Graham Fenton, Hagar Taman, Jon Florholmen, Ruth H Paulssen :
    Transcriptional profiling of ulcerative colitis in remission
    Journal of Crohn's and Colitis 25. januar 2019 ARKIV / DOI
  • Ruth H Paulssen, Hagar Mohamed Taman, Christopher Graham Fenton, Inga Viktoria Hensel, Endre Anderssen, Jon Florholmen :
    Novel regulatory DNA methylation features of relevance for ulcerative colitis
    American Journal of Gastroenterology 2018 DOI
  • Ruth H Paulssen, Hagar Mohamed Taman, Christopher Graham Fenton, Inga Viktoria Hensel, Endre Anderssen, Jon Florholmen :
    Novel regulatory DNA methylation features of relevance for ulcerative colitis
    2017
  • Mona Dixon Gundersen, Rasmus Goll, Jon Florholmen, Ruth H Paulssen :
    Mucosal healing in active ulcerative colitis treated with infliximab to disease remission
    Inflammatory Bowel Diseases 2016
  • Ruth H Paulssen, Rasmus Goll, Jon Florholmen :
    PROFILE: As inflammatory bowel disease grows in global incidence, Dr Jon Florholmen outlines what could help to create a cure
    PAN european networks science and technology 2014
  • Vasilis Sitras, Christopher Graham Fenton, Ruth H Paulssen, Åse VÅrtun, Ganesh Acharya :
    Global gene expression profiling in the first and third trimesters of normal human pregnancy
    Placenta 2011
  • Vasilis Sitras, Christopher Graham Fenton, Ruth H Paulssen, Åse VÅrtun, Ganesh Acharya :
    GLOBAL PLACENTAL GENE EXPRESSION PROFILING IN THE FIRST AND THIRD TRIMESTERS OF NORMAL HUMAN PREGNANCY
    Placenta 2011
  • Turid Hellevik, Inger Pettersen, Jan-Olof Winberg, Vivian Berg, Ruth H Paulssen, Kristian Bartnes m.fl.:
    The Impact of Ionizing Radiation on the Motility and Matrix Remodelling Properties of Carcinoma-associated Fibroblasts
    European Journal of Cancer 2011
  • trine Lund, Margareth Bergesen Hals, Ruth H Paulssen, Kirsti Ytrehus :
    Increased gene expression diversity between female and male hearts after transverse aortic constriction (TAC)
    2009
  • trine Lund, Margareth Bergesen Hals, Ruth H Paulssen, Kirsti Ytrehus :
    Increased gene expression diversity between female and male mice hearts after transverse aortic constriction (TAC)
    2009
  • Karina Standahl Olsen, CG Fenton, Endre Anderssen, Livar Frøyland, RH Paulssen, E Lund :
    Associations between serum linolenic acid/alpha-linolenic acid ratio and blood gene expression profiles
    The FEBS Journal 2009
  • trine Lund, Margareth Bergesen Hals, Ruth H Paulssen, Kirsti Ytrehus :
    Increased gene expression diversity between female and male hearts after transverse aortic constriction (TAC)
    European Journal of Heart Failure. Supplements 2009
  • Kristin Snipstad, Christopher Graham Fenton, J Kjaeve, Jørn Kjæve, Endre Anderssen, Ruth H Paulssen :
    New specific molecular targets for radiochemotherapy in colorectal cancer
    The FEBS Journal 2009
  • vanessa Dumeaux, Karina Standahl Olsen, Jørn Leirvik, Ruth H Paulssen, AL Borresen-Dale, Eiliv Lund :
    Variation of gene expression profiles in whole blood from a large representative sample of postmenopausal Norwegian women
    European Journal of Cancer 2008
  • Vasilis Sitras, Ruth H Paulssen, Halvor Grønaas, Åse VÅrtun, Ganesh Acharya :
    Placental Gene Expression in Severe Preeclampsia. (Abstracts of the 20th European Congress of Obstetrics and Gynaecology)
    Acta Obstetrica Ginecologica Portuguesa 2008

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    Publikasjoner utenom Cristin

    R.H. Paulssen, E.J. Paulssen, J.O. Gordeladze and K.M. Gautvik: THE ELUCIDATION OF RECEPTOR-EFFECTOR COUPLING IN RAT PITUITARY (GH3) CELLS BY THE USE OF ANTISENSE TECHNIQUES. J.Cell.Biochem. (1991) Suppl. 15D:26.

    G. Jablonski, B.M. Mortensen, R.H. Paulssen, H.W. Lund and J.O. Gordeladze: THE EFFECT OF UREMIA AND ALUMINIUM INTOXICATION ON HORMONE SIGNALING IN THE OSTEOBLAST. J. Bone Miner. Res. (1992), 7 Suppl. 1:225.

    R.H. Paulssen, N. Fraeyman and J. Florholmen: ACTIVATION OF PHOPHOLIPASE C BY CHOLECYSTOKININ IN INSULIN (b-TC3)-, SOMATOSTATIN (Rin1027-B2)- AND GLUCAGON (INR1-G9)- SECRETING PANCREATIC CELL LINES: IDENTIFICATION OF DIFFERENT CCK-RECEPTOR SUBTYPES AND G PROTEIN-COUPLING SPECIFICITIES. FASEB J. (1997), 11 Suppl. 9: 2767.

    N.V. Ermakova, R.H. Paulssen and J. Florholmen: THE EFFECT OF TNF-a ON CELL GROWTH AND PLC-g EXPRESSION IN INSULIN-SECRETING b-CELLS. Diabetologia (1999), 42:529.

     J.B. Hansen, B. Svensson, B. Østerud, R. Olsen, M. Ezban and R.H. Paulssen: HEPARIN INDUCES SYNTHESIS AND SECRETION OF TISSUE FACTOR PATHWAY INHIBITOR (TFPI) FROM ENDOTHELIAL CELLS IN VITRO. Thromb. Haemostasis (1999), Suppl. 92.

    N.V. Evgenov, R.H. Paulssen, O.V. Evgenov, I. Christiansen and J. Florholmen: TUMOR NECROSIS FACTOR-a INDUCES APOPTOSIS IN AN INSULIN-SECRETING b-CELL LINE. Diabetes Res.Clin.Practice (2000), 50:S150.

    R. H. Paulssen, J. Sørli, N.V. Evgenov and S. Krum-Hansen: REGULATION AND EXPRESSION OF PROTEIN KINASE C ISOFORMS BY CHOLECYSTOKININ AND GASTRIN IN A SOMATOSTATIN-SECRETING PANCRETIC Rin1027-B2 CELL LINE. Eur.J.Biochem (2001), 268, Suppl. 1:103.

    N. Fraeyman and R. Paulssen: CENTRAL ROLE OF PKCa IN THE DESENSITISATION OF M3-MUSCARINIC RECEPTORS. Eur.J.Biochem. (2001), 268, Suppl. 1: 92.

    L. Thommesen, E. Hofsli, R.H. Paulssen, M.W. Anthonsen, and A. Lægreid: MOLECULAR MECHANISMS INVOLVED IN GASTRIN MEDIATED REGULATION OF cAMP-RESPONSIVE (CRE) PROMOTOR ELEMENT. Am.J.Physiol. – Endocrinol. And Metab. APStracts (2001), 8:0201E.

    E. Mortensen, L. Hansen, N. Bjurstam, S. Klenow, J.O. Frantzen and R.H. Paulssen: IMPRINT OF CORE BIOPSIES AS A RELIABLE DIAGNOSTIC TOOL IN BREAST CANCER AND POSSIBLE USEFULNESS FOR RESEARCH PURPOSES. Breast Cancer Res. (2005), 7, Suppl.  2:33.

    R.H. Paulssen, L. Olsen, and T.C. Sogn: MagNA PURE COMPACT RNA ISOLATION KIT: ISOLATION OG HIGH-QUALITY TOTAL RNA SAMPLES FROM A BROAD RANGE OF SAMPLE MATERIAL. Biochemica (2006), 2:14-16.

    V. Sitras, R.H. Paulssen, H. Grønaas, and G. Acharya: GENE EXPRESSION PROFILE IN LABORING AND NON-LABORING PLACENTA NEAR TERM.  Am. J. Obst. Gynecol. (2007), 195, Suppl. S197.

    V. Dumeaux, K.S. Olsen, J. Leirvik, R.H. Paulssen, A.L. Borresen-Dale, and E. Lund: VARIATION OF GENE EXPRESSION PROFILES IN WHOLE BLOOD FROM A LARGE REPRESENTATIVE SAMPLE OF POSTMENOPAUSAL NORWEGIAN WOMEN. Eur. J. Cancer (2008), 6, Suppl. 9:97.

    K.S. Olsen, C.G. Fenton, E. Anderssen, L. Frøyland, R.H. Paulssen, and E. Lund: ASSOCIATIONS BETWEEN SERUM LINOLENIC ACID/ALPHA-LINOLENIC ACID RATIO AND BLOOD GENE EXPRESSION PROFILES, FEBS J. (2009), 276, Suppl. 1:115-116.

    K. Snipstad, C.G. Fenton, J. Kjæve, E. Anderssen and R.H. Paulssen: NEW SPECIFIC MOLECULAR TARGETS FOR RADIOCHEMOTHERAPY IN COLORECTAL CANCER, FEBS J. (2009), 276, Suppl. 1:121.

    T. Lund, M.B. Hals, R.H. Paulssen, and K. Ytrehus: INCREASED GENE EXPRESSION DIVERSITY BETWEEN FEMALE AND MALE MICE HEARTS AFTER TRANSVERSE AORTIC CONTRICTION (TAC). Eur. J. Heart Failure Supplements (2009), 8 (2).

    K.S. Olsen, C. Fenton, E. Anderssen, L. Frøyland, R.H. Paulssen, V. Dumeaux, and E. Lund: EEFECTS OF PLASMA FATTY ACID RATIOS ON THE BLOOD TRANSCRIPTOME. Norwegian Journal of Epidemiology (2009), 19: Suppl. 1:9.

    V. Sitras, C. Fenton, R.H. Paulssen, A. Vårtun and G. Acharya: GLOBAL PLACENTAL GENE EXPRESSION PROFILING IN THE FIRST AND THIRD TRIMESTERS OF NORMAL HUMAN PREGNANCY. Placenta (2011), 32: A136, P2.117.

    Electro Cell Manipulator Ô, ECMâ600 Electroporation Protocol 0055, BTX Dicision of  GenetronicsÓ (BTX ID #1130).

    Compendium to User Course  “Introduction to Microarray Technology and Data Analysis” (Annual Issues 2004 -2010).

     FEBS News, Issue 5, September 2008, p. 11.

     FEBS News, Issue 5, October 2009, p. 8-9.

     FEBS News, Issue 4, October 2010, p. 8.

    Compendium to User Course “Introduction to High-Throughput Genomics and Data Analysis” (2012).

     


    CV

    Name:                        Ruth Hracky Paulssen

    Date of Birth:            30.08.57

    Nationality:              German/Norwegian

    Marital status:         Married, two children

    Education

    1986:               Diploma in Biochemistry at University of Hannover, Germany. Diploma work at the Botanical Institute, Ludwig-Maximillians University Munich, Germany. Title: «Phosphorylation/Dephosphorylation in the Cytosolof Pea Mesophyll cells».

    1992:               Ph.D., University of Oslo. Thesis title: «G protein-coupled Transmembrane Signalling in Prolactin-Producing rat Pituitary Tumour Cells».

     Appointments

    1981 – 1984:   Research Assistant at the Institute of Clinical Chemistry, Veterinary University Hannover, Germany.

    1985 – 1987:   Student Fellow, Botanical Institute, Ludwig-Maximillians University Munich, Germany.

    1986:             Research Assistant, Botanical Institute, Ludwig-Maximillians University Munich, Germany.

    1988:              Bioengineer, Institute of Medical Biochemistry, University of Oslo, Norway.

    1989-1993:     Ph.D. Student (The Norwegian Cancer Society Fellowship), Institute of Medical Biochemistry, University of Oslo, Norway.

    1993-1995:     Post doctoral Fellow (The Human Frontier Science Program Organization, HFSPO Long-term Fellowship), Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, USA.

    1996-1998:     Research Scientist, Institute of Clinical Medicine, University of Tromsø, Norway.

    1999-2004      Associate professor, Institute of Clinical Medicine, Laboratory of Molecular Medical Research, University of Tromsø and University Hospital of North Norway (UNN), Tromsø, Norway.

    Since 2005      Professor, Department of Clinical Medicine, University of Tromsø, Tromsø, Norway.