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Telefon: +4777646657


Conference presentations

9) Dominik Ausbacher; Lindsey A. Lorenz; Darla M. Goeres; Philip S. Stewart ; Morten B. Strøm; Pia M. Vuorela; Adyary Fallarero. Antimicrobial β2,2-amino acid derivatives eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal. DPhG Annual Meeting, Munich (2016).

8) Leena Hanski, Dominik Ausbacher; Morten B. Strøm; Pia M. Vuorela. Impact of β2,2-amino acid derivatives, a novel class of Chlamydia pneumoniae inhibitors, on bronchial epithelium VEGF production. Conference on Lung and Respiratory Care, Manchester (2016).

7) Adyary Fallarero, Malena Skogman, Vânia Moreira, Suvi Manner, Dominik Ausbacher, Reko Leino, Morten B. Strøm, Jari Yli-Kauhaluoma, Pia M. Vuorela. The challenges of discovering new anti-biofilm probes from a high-throughput screening (HTS) perspective. Eurobiofilms 2013 - 3rd European Congress on Microbial Biofilms - Basic and Clinical Aspects, Ghent (2013).

6) Leena Pohjala, Dominik Ausbacher, Morten B. Strøm, Pia M. Vuorela. Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides. 7th meeting of the European society for Chlamydia research, Amsterdam (2012).

5) Dominik Ausbacher, Janni Kujala, Pia M. Vuorela, Morten B. Strøm, Adyary Fallarero. Control of Staphylococcus aureus biofilm with highly active β2,2-amino acid derivatives. 3rd International Symposium on Antimicrobial Peptides, Lille (2012).

4) Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm. Mechanisms of cancer cell death induced by novel cationic β-peptidomimetics. 22nd American Peptide Symposium, San Diego (2011).

3) Terkel Hansen, Dominik Ausbacher, Martina Havelkova, Morten B. Strøm. Bactericidal activity of small β-peptidomimetics. 31. European Peptide Symposium, Copenhagen (2010).

2) Veronika Tørfoss, Dominik Ausbacher, Terkel Hansen, Martina Havelkova, Morten B. Strøm Anticancer activity of small cationic β-peptidomimetics. 31. European Peptide Symposium, Copenhagen (2010).

1) C. Becker, A. Ehmer, A. Maschke, A. Meindorfer, D. Ausbacher, J. Tessmar, T. Blunk, A. Goepferich. Influence of Micronisation of Proteins on the Properties of Lipid Microparticles for Controlled Release. DPhG Joint Meeting, Marburg (2006).



17) Eksteen, J. J.; Ausbacher, D.; Vasskog, T.; Rekdal, Ø.; Svendsen, J. S. M. (2020). Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors. ACS Omega DOI: 10.1021/acsomega.9b00700

16) Paulsen, M.H.; Ausbacher, D.; Bayer, A.; Engqvist, M; Hansen, T.; Haug, T.; Anderssen, T.; Andersen, J.H.; Ericson Sollid J.U.; Strøm, M.B. (2019). Antimicrobial activity of amphipathic α, α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character. European Journal of Medicinal Chemistry. DOI: 10.1016/j.ejmech.2019.111671

15) Paulsen, M.H.; Karlsen, E.A.; Ausbacher, D.; Anderssen, T.; Bayer, A.; Ochtrop, P.; Hedberg, C.; Haug, T.; Ericson Sollid, J.U.; Strøm M.B. (2018). An amphipathic 13-membered cyclic tetrapeptide scaffold containing β2,2-amino acids with activity against multi-resistant bacteria. Journal of Peptide Science. DOI: 10.1002/psc.3117

14) Ausbacher, D; Lorenz, L.A.; Pitts, B.; Stewart, P.S.; Goeres, D.M. (2017). Paired methods to measure biofilm killing and removal: a case study with Penicillin G treatment of Staphylococcus aureus biofilm. Letters in Applied Microbiology. DOI: 10.1111/lam.12843.

13) Eksteen, J.J.; Ausbacher, D.; Simon-Santamaria, J.; Stiberg, T.; Cavalcanti-Jacobsen, C.; Wushur, I.; Svendsen, J.S.; Rekdal, Ø. (2016). Iterative design and in vivo Evaluation of an oncolytic antilymphoma peptide. Journal of Medicinal Chemistry. DOI: 10.1021/acs.jmedchem.6b00839.

12) Paulsen, M.H.; Engqvist, M.; Ausbacher, D.; Strøm, M. B.; Bayer, A. (2016). Efficient and scalable synthesis of α,α-­disubstituted β-amino amides. Organic and biomolecular chemistry . ISSN 1477-0520.s DOI: 10.1039/C6OB01219A.

11) Hanski, L.#; Ausbacher, D.#; Tiirola, T.M.; Strøm, M.B.; Vuorela, P.M. (2016). Amphipathic β2,2-amino acid derivatives suppress infectivity and Ddsrupt the intracellular replication cycle of Chlamydia pneumoniae. PLoS ONE, 11(6). DOI: 10.1371/journal.pone.0157306. #contributed equally

10) Sivertsen, A.; Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Anderssen, T.; Brandsdal, B. O.; Havelkova, M.; Skjørholm, A. E.; Strøm M.B. (2013). Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide-binding to human serum albumin. J. Pept. Sci., 20: 279-291.

9) Ausbacher, D.; Fallarero, A.; Kujala, J.; Määttänen, A; Jouko, Peltonen; Strøm, M.B.; Vuorela, P.M. (2014). Staphylococcus aureus biofilm susceptibility to small and potent β2,2-amino acid derivatives. Biofouling, 30: 81-93. DOI: 10.1080/08927014.2013.847924

8) Ausbacher, D.; Svineng, G.; Hansen, T.; Strøm M.B. (2012). Anticancer mechanisms of action of two small amphipathic β2,2-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1818: 2917-2925. DOI: 10.1016/j.bbamem.2012.07.005

7) Hansen, T.; Ausbacher, D.; Zachariassen, Z.G.; Anderssen, T.; Havelkova, M.; Strøm M.B. (2012) Anticancer activity of small amphipathic β2,2-amino acid derivatives, European Journal of Medicinal Chemistry, 58: 22-29.

6) Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Brandsdal, B. O.; Flaten, G. E.; Anderssen, T.; Cavalcanti-Jacobsen, C. de A.; Havelkova, M.; Nguyen, L. T.; Vogel, H. J.; Strøm, M. B. (2012) Improved anticancer potency by head-to-tail cyclisation of short cationic anticancer peptides containing a lipophilic β2,2-amino acid, Journal of Peptide Science, 18: 609-619.

5) Tørfoss, V.; Ausbacher, D.; Cavalcanti-Jacobsen, C.deA.; Hansen, T.; Brandsdal, B-.O.; Havelkova, M.; Strøm, M.B. (2011): Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block, Journal of Peptide Science 18: 170-176.

4) Hansen, T.; Ausbacher, D.; Flaten, G. E.; Havelkova, M.; Strøm, M. B.(2011): Synthesis of cationic antimicrobial β2,2-amino acid derivatives with potential for oral administration, Journal of Medicinal Chemistry 54: 858-868.

3) Hupfeld, S.; Moen, H. H.; Ausbacher, D.; Haas, H.; Brandl, M. (2010): Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid. Chemistry and Physics of Lipids 163: 141-147.

2) Hupfeld, S.; Ausbacher, D.; Brandl, M. (2009): Asymmetric flow field-flow fractionation of liposomes: 2. Concentration-detection and adsorptive loss phenomena. Journal of Separation Science 32: 3555-3561.

1) Hupfeld, S.; Ausbacher, D.; Brandl, M. (2009): Asymmetric flow field-flow fractionation of liposomes: optimization of fractionation variables. Journal of Separation Science 32: 1465-1470.


Personal overseas research grant of the Research Council of Norway (2014/15)

UiT transition grant for recruitment of young researchers (2012/13)

UiT mobility grant for research abroad (2011)

Travel grant of the Norwegian Pharmaceutical Society (2011)


Studies and Education

09/2015 - 02/2017
Postdoc, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group, Prof. M. B. Strøm, UiT-The Arctic University of Norway

03/2015 - 08/2015
Postdoc, Center for Biofilm Engineering, Standardized Biofilm Methods Laboratory, Assistant Prof. D. Goeres and Biofilm Control Laboratory, Prof. P.Stewart, Montana State University, Bozeman, USA

09/2014 - 02/2015
Postdoc, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Anti-infective Research Laboratory, Adjunct Prof. A. Fallarero and Prof. P. Vuorela, University of Helsinki, Finland

03/2013 - 08/2014
Postdoc, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group, Prof. M. B. Strøm, UiT-The Arctic University of Norway

11/2012 - 02/2013
Researcher, Faculty of Health Sciences, UiT-The Arctic University of Tromsø

PhD thesis defence: Biological activity of β2,2-amino acid derivatives derived from antimicrobial peptides- Investigations of Antimicrobial and Anticancer Activity and the Mechanisms of Action

11/2011 - 02/2012
Visiting PhD student, Pharmacutical Sciences Laboratory, Prof. P. Vuorela, Åbo Akademi University, Turku, Finland

10/2008 - 09/2012
Ph.D. student, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group Prof. M. B. Strøm, UiT-The Arctic University of Norway

07/2008 and 12/2012
Licensure for the profession as pharmacist in Germany and Norway

Diploma defence, A4F/MALS Analysis of Liposomes, Faculty of Biosciences, Department of Pharmaceutical Technology Prof. K. Mäder, University of Halle, Germany

05/2007 - 10/2007
Diploma student, Faculty of Health Sciences, Drug Transport and Delivery Research Group Prof. M. Brandl, UiT-The Arctic University of Norway

Second State Exam

First State Exam

10/2002 - 04/2007
Pharmacy studies, University of Regensburg, Germany

Karlsgymnasium Bad Reichenhall, University-entrance diploma



German (native)


Work experience

Researcher for Epitarget AS, Oslo

11/2007 - 04/2008
Pharmacist in practical training, Ahorn Apotheke, Regensburg

09/2006 - 10/2006
Aenova Sales Pharma - Dragenopharm-Apotheker Püschel GmbH & Co. KG, Tittmoning

07/2001 - 06/2002
Service in the mountain infantry batallion Berchtesgaden, Armed forces of Germany


Telefon: +4777646169
  • Permeabilitet over biologiske barrierer
  • The phospholipid vesicle-based permeation assay (PVPA)
  • Liposomer som legemiddelbærer
  • Liposomer som modellsystem for celler og bakterier i interaksjonsstudier
  • Delivery av lipofile virkestoff


Telefon: +4777646719

Mine forskningsinteresser samsvarer med forskningsinteressene til gruppa "Drug transport and delivery".

og angår formulering og optimalisering av legemiddelformuleringer for topikal- (sårbehandling) og systemisk- (injeksjonsmedisin) administrasjo mtp:

  • Holdbarhet/stabilitet
  • Brukervennlighet
  • Effekt
  • Bivirkningsprofil
  • Fremstillingsmetode


Karakterisering av legemiddelformuleringens fysikalskjemiske-, biofarmasøytiske- og kliniske/terapeutiske egenskaper skjer vha a in vitro, ex vivo og in vivo testing.



Telefon: +4777644070
  • Makromolekylers struktur og funksjon
  • Det molekylære opphav til enzymers kuldeadaptasjon
  • Utvikling av enzymer for anvendelse
  • Bioprospektering

Telefon: +4777644085


1) Design, synthesis and development of antimicrobial and anticancer peptides and peptidomimetics as lead-compounds for drug-development and investigation of pharmacophore models.

2) Design and synthesis of peptidomimetics and bioactive scaffolds for optimization of potency and pharmacokinetic properties.

3) Isolation and structural elucidation of marine bioactive compounds from Arctic and sub-Arctic marine invertebrates and synthesis of marine natural product mimics (marine bio-prospecting).


Veiledning av PhD studenter

2000 – 2004: Biveileder for Dr. Morten K. Moe - Tittel på PhD avhandling: ESI low-energy tandem MS characterisation of lipids modified by a novel derivatisation method. Finansiert av Norges Forskningsråd.

2007 – 2010: Biveileder for Dr. Margey Tadesse - Tittel på PhD avhandling: Antimicrobial natural products from Arctic and sub-Arctic marine invertebrates. Finansiert av UiT.

2007 – 2011: Hovedveileder for Dr. Terkel Hansen (cand. pharm.) - Tittel på PhD avhandling: Antimicrobial and anticancer beta-peptidomimetics – synthesis and biological evaluation of a new class of small and highly potent compounds. Finansiert av UiT.

2008 – 2012: Hovedveileder for Dominik A. Ausbacher (cand. pharm.) - Tittel på PhD avhandling: Biological activity of β2,2-amino acid derivatives derived from antimicrobial peptides - Investigations of antimicrobial and anticancer activity and the mechanisms of action. Finansiert av UiT.

2008 – 2013: Hovedveileder for Veronika Tørfoss (cand. pharm.) - Tittel på avhandling: Short anticancer peptides containing a lipophilic β2,2-amino acid - Synthesis and biological evaluation of linear and cyclic hepta-, hexa-, penta-, and tetrapeptides. Finansiert av Norges Forskningsråd (KOSK-II programmet).

2011 – 2015: Biveileder for Elisabeth Klungerbo Olsen (cand. pharm.) - Tittel på avhandling: Bioprospecting of Arctic marine organisms. Finansiert av MabCent – SFI.

2011 – pågående prosjekt: Hovedveileder for Elizaveta Mikhailovna Igumnova - Arbeidstittel: Chemical synthesis, isolation, and structural characterization of marine bioactive hit compounds. Finansiert av MabCent – SFI.

2011 – 2016: Biveileder for Runar Gjerp Solstad - Tittel på avhandling: Discovery of antimicrobial peptides in two invertebrates, the sea anemone Urticina eques and the sea urchin chinus esculentus - Isolation, characterization and structure-activity relationship studies. Finansiert av UiT.

2012 - 2017: Hovedveileder for Marianne Hagensen Paulsen - Tittel på avhandling: Synthetic mimics of antimicrobial peptides. Synthesis and biological studies of novel synthetic mimics of antimicrobial peptides. Finansiert av Norges Forskningsråd og UiT - "Fellesløftet".

2014 - 2017: Biveileder for Thomas Aleksander Bakka (NTNU - Trondheim) - Tittel på avhandling: Synthesis and antimicrobial evaluation of small molecule amphiphiles derived from amphiphilic antimicrobial natural products. Finansiert av NTNU.

2018 - pågående prosjekt: Biveileder for Manuel Karl Langer (Institutt for kjemi - IKJ, UiT) - Arbeidstittel: Synthesis of new antimicrobial, antibiofilm and antifouling agents. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger".

2018 - pågående prosjekt : Hovedveileder for Danijela Simonovic (Institutt for farmasi - IFA, UiT) - Arbeidstittel: Synthesis of antimicrobial amphipathic scaffolds targeting multi-resistant bacteria. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger" - LEADScAMR.

2018 - pågående prosjekt: Biveileder for Christoffer Ågnes Sivertsen (Fakultet for biovitenskap, fiskeri og økonomi - BFE, NFH UiT) - Arbeidstittel: Antibacterial and antibiofilm compounds in Arctic and sub-Arctic invertebrates. Finansiert av UiT - Norges arktiske universitet - "Tematiske satsninger" - AntifoMar.

2019 - pågående prosjekt: Biveileder for Susannah von Hofsten (Institutt for medisinsk biologi - IMB, UiT) - Arbeidstittel: Identifisering og utvikling av anticancer peptider og peptidomimetika for målrettet behandling av kreft. Finansiert av UiT - Norges arktiske universitet.


Veiledning av masterstudenter

Jeg har siden 2003 vært veileder for 28 mastergradsstudenter i farmasi / legemiddelkjemi / organisk kjemi.


Telefon: +4777620909