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Bilde av Hansen, Hilde
Bilde av Hansen, Hilde
Institutt for kjemi hilde.hansen@uit.no +4777620898 Tromsø

Hilde Hansen

Forsker, Biomolekylær og strukturkjemi

  • Mikkel Christensen, Iulia Chiciudean, Piotr Jablonski, Ana Maria Tanase, Volha Shapaval, Hilde Hansen :
    Towards high-throughput screening (HTS) of polyhydroxyalkanoate (PHA) production via Fourier transform infrared (FTIR) spectroscopy of Halomonas sp. R5-57 and Pseudomonas sp. MR4-99
    PLOS ONE 2023 ARKIV / DOI
  • Netsanet Gizaw Assefa, Hilde Hansen, Bjørn Altermark :
    A unique class I polyhydroxyalkanoate synthase (PhaC) from Brevundimonas sp. KH11J01 exists as a functional trimer: A comparative study with PhaC from Cupriavidus necator H16
    New Biotechnology 2022 ARKIV / DOI
  • Amudha Deepalakshmi Maharajan, Erik Hjerde, Hilde Hansen, Nils P Willassen :
    Quorum Sensing Controls the CRISPR and Type VI Secretion Systems in Aliivibrio wodanis 06/09/139
    Frontiers in Veterinary Science 2022 ARKIV / DOI
  • Mikkel Christensen, Piotr Jablonski, Bjørn Altermark, Knut Irgum, Hilde Hansen :
    High natural PHA production from acetate in Cobetia sp. MC34 and Cobetia marina DSM 4741T and in silico analyses of the genus specific PhaC2 polymerase variant
    Microbial Cell Factories 2021 ARKIV / FULLTEKST / DOI
  • Amudha Deepalakshmi Maharajan, Hilde Hansen, Miriam Khider, Nils Peder Willassen :
    Quorum sensing in Aliivibrio wodanis 06/09/139 and its role in controlling various phenotypic traits
    PeerJ 2021 ARKIV / DOI
  • Irina Lascu, Ioana Mereuță, Iulia Chiciudean, Hilde Hansen, Sorin Marius Avramescu, Ana-Maria Tănase m.fl.:
    Complete genome sequence of Photobacterium ganghwense C2.2: A new polyhydroxyalkanoate production candidate
    MicrobiologyOpen 2021 ARKIV / DOI
  • Miriam Khider, Hilde Hansen, Erik Hjerde, Jostein a Johansen, Nils Peder Willassen :
    Exploring the transcriptome of luxI- and ΔainS mutants and the impact of N-3-oxo-hexanoyl-L- and N-3-hydroxy- decanoyl-L-homoserine lactones on biofilm formation in Aliivibrio salmonicida
    PeerJ 2019 ARKIV / DOI
  • Miriam Khider, Erik Hjerde, Hilde Hansen, Nils Peder Willassen :
    Differential expression profiling of ΔlitR and ΔrpoQ mutants reveals insight into QS regulation of motility, adhesion and biofilm formation in Aliivibrio salmonicida
    BMC Genomics 2019 ARKIV / DOI
  • Miriam Khider, Nils Peder Willassen, Hilde Hansen :
    The alternative sigma factor RpoQ regulates colony morphology, biofilm formation and motility in the fish pathogen Aliivibrio salmonicida
    BMC Microbiology 2018 FULLTEKST / ARKIV / DOI
  • Sunniva Katharina Thode, Cecilie Bækkedal, Jenny Johansson Söderberg, Erik Hjerde, Hilde Hansen, Peik Haugen :
    Construction of a fur null mutant and RNA-sequencing provide deeper global understanding of the Aliivibrio salmonicida Fur regulon
    PeerJ 2017 ARKIV / DOI
  • Hilde Hansen, Amit Anand Purohit, Hanna-Kirsti S. Leiros, Jostein Johansen, Stefanie J. Kellermann, Ane Mohn Bjelland m.fl.:
    The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicida
    BMC Microbiology 2015 ARKIV / DOI
  • Sunniva Katharina Thode, Tim Kahlke, Espen Mikal Robertsen, Hilde Hansen, Peik Haugen :
    The immediate global responses of Aliivibrio salmonicida to iron limitations
    BMC Microbiology 2015 ARKIV / DOI
  • Hilde Hansen, Jostein a Johansen, Hanna-Kirsti S. Leiros, Amit Anand Purohit, Nils Peder Willassen, Ane Mohn Bjelland m.fl.:
    The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicida
    BMC Microbiology 2015 DOI
  • Hilde Hansen, Ane Mohn Bjelland, Maria Pain, Espen Mikal Robertsen, Nils Peder Willassen :
    LitR Is a Repressor of syp Genes and Has a Temperature-Sensitive Regulatory Effect on Biofilm Formation and Colony Morphology in Vibrio (Aliivibrio) salmonicida
    Applied and Environmental Microbiology 2014 DOI
  • Amit Anand Purohit, Jostein a Johansen, Hilde Hansen, Hanna-Kirsti S. Leiros, Alexander Kashulin, Christian Karlsen m.fl.:
    Presence of acyl-homoserine lactones in 57 members of the Vibrionaceae family
    Journal of Applied Microbiology 2013 ARKIV / DOI
  • Ane Mohn Bjelland, Henning Sørum, Daget Ayana Tegegne, Hanne Cecilie Winther-Larsen, Nils Peder Willassen, Hilde Hansen :
    LitR of Vibrio salmonicida Is a Salinity-Sensitive Quorum-Sensing Regulator of Phenotypes Involved in Host Interactions and Virulence
    Infection and Immunity 2012 DOI
  • Ane Mohn Bjelland, Renate Johansen, Espen Brudal, Hilde Hansen, Hanne Cecilie Winther-Larsen, Henning Sørum :
    Vibrio salmonicida pathogenesis analyzed by experimental challenge of Atlantic salmon (Salmo salar)
    Microbial Pathogenesis 2012 DOI
  • malachy ifeanyi Okeke, Hilde Hansen, Terje Traavik :
    A naturally occurring cowpox virus with an ectromelia virus A-type inclusion protein gene displays atypical A-type inclusions
    Infection, Genetics and Evolution 2012 DOI
  • Rafi Ahmad, Geir Åsmund Hansen, Hilde Hansen, Erik Hjerde, hege lynum Pedersen, steinar Paulsen m.fl.:
    Prediction, microarray and northern blot analyses identify new intergenic small RNAs in aliivibrio salmonicida
    Journal of Molecular Microbiology and Biotechnology 28. desember 2012 DOI
  • hege lynum Pedersen, erik Hjerde, steinar Paulsen, Hilde Hansen, Lotte Olsen, Sunniva Katharina Thode m.fl.:
    Global responses of Aliivibrio salmonicida to hydrogen peroxide as revealed by microarray analysis
    Marine Genomics 2010 DOI
  • Steinar D. Johansen, Åse Emblem, Bård Ove Karlsen, Siri Okkenhaug, Hilde Hansen, Truls Moum m.fl.:
    Approaching marine bioprospecting in hexacorals by RNA deep sequencing
    New Biotechnology 2010 DOI
  • Hilde Hansen, Malachy Ifeanyi Okeke, Øivind Nilssen, Terje Traavik :
    Comparison and phylogenetic analysis of cowpox viruses isolated from cats and humans in Fennoscandia
    Archives of Virology 2009 DOI
  • Rainer Winnenburg, Martin Urban, Andrew Beacham, Thomas K Baldwin, Sabrina Holland, Magdalen Lindeberg m.fl.:
    PHI-base update: additions to the pathogen-host interaction database
    Nucleic Acids Research (NAR) 2008 ARKIV / DOI
  • Christine H Rinaldo, Hilde Hansen, Terje I Traavik :
    Human endothelial cells allow passage of an archetypal BK virus (BKV) strain - a tool for cultivation and functional studies of natural BKV strains
    Archives of Virology 2005
  • Kjetil Åsbakk, Snorre Stuen, Hilde Hansen, Lorry Forbes :
    A serological survey for brucellosis in reindeer in Finnmark county, northern Norway
    Rangifer 1999
  • Inger Lin Uttakleiv Ræder, Bjørn Altermark, Hilde Hansen :
    Rester fra fiskeri blir bioplast, kosmetikk og kosttilskudd
    Forskning.no 26. august 2019
  • Iulia Chiciudean, Ioana Mereuta, Elena Luiza Mihalachi, Irina Lascu, Sorin Marius Avramescu, Piotr Jablonski m.fl.:
    Halotolerant Black Sea bacteria for bioplastics production
    2019
  • Hilde Hansen, Bjørn Altermark, Mikkel Christensen :
    Confronting Plastic Pollution With Bacteria
    Journal of the North Atlantic & Arctic 2019 FULLTEKST
  • Hilde Hansen :
    Naturens små plastfabrikker
    2019
  • Mikkel Christensen, Piotr Jablonski, Seila Pandur, Netsanet Gizaw Assefa, Bjørn Altermark, Hilde Hansen :
    Investigation of promising bioplastic producing Arctic marine bacteria from the Halomonadacea family
    2019
  • Netsanet Gizaw Assefa, Mikkel Christensen, Seila Pandur, Bjørn Altermark, Hilde Hansen :
    Conversion of renewable feedstocks into bioplastics by Arctic marine bacteria
    2019
  • Hilde Hansen, Bjørn Altermark, Mikkel Christensen :
    Confronting one of our greatest challenges – plastic waste in nature
    Fram Forum 2019 FULLTEKST
  • Mikkel Christensen, Piotr Jablonski, Seila Pandur, Netsanet Gizaw Assefa, Bjørn Altermark, Hilde Hansen :
    Arctic marine bacteria for bioplastic production
    2018 ARKIV
  • Netsanet Gizaw Assefa, Hilde Hansen, Bjørn Altermark, Seila Pandur, Arne O. Smalås :
    Biodegradable and sustainable plastics from marine bacteria
    2017
  • Mikkel Christensen, Bjørn Altermark, Netsanet Gizaw Assefa, Seila Pandur, Arne O. Smalås, Hilde Hansen :
    Arctic, marine bacteria and their ability to produce polyhydroxyalkonates (PHAs) using underexploited biomass as nutrient source
    2017
  • Hilde Hansen :
    Bruk og kast med god samvittighet! Bakterier fra havet blir engangsbestikk.
    2017 OMTALE
  • Bjørn Altermark, Hilde Hansen, Seila Pandur :
    Framtidas plast kan spises
    Klassekampen 25. juni 2017
  • Bjørn Altermark, Hilde Hansen, Seila Pandur :
    Bakterier blir engangsbestikk
    Kunnskapsmagasinet Labyrint 2016
  • Miriam Khider, Peik Haugen, Hilde Hansen, Nils Peder Willassen :
    Development of an expression host for cold-adapted enzymes
    2014
  • Miriam Khider, Peik Haugen, Hilde Hansen, Nils Peder Willassen :
    Cloning and Characteriza0on of PUFA operon form Shewanella, with focus on EPA and DHA production in Aliivibrio wodanis
    2014
  • Jörn Klein, Hilde Hansen, Morten Tryland :
    Characterisation of Norwegian reindeer parapoxvirus isolates. A comparative study
    2004

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    Publikasjoner utenom Cristin

    Publications not listed in CRIStin

    Hansen H, Okeke MI, Nilssen Ø, Traavik T (2004). Recombinant viruses obtained from co-infection in vitro with a live vaccinia-vectored influenza vaccine and a naturally occurring cowpox virus display different plaque phenotypes and loss of the transgene. Vaccine 23(4):499-506.

    Hansen H, Sandvik T, Tryland M, Olsvik Ø, Traavik T (1999). Comparison of thymidine kinase and A-type inclusion protein gene sequences from Norwegian and Swedish cowpox virus isolates. APMIS 107(7):667-75.

    Sandvik T, Tryland M, Hansen H, Mehl R, Moens U, Olsvik Ø, Traavik T (1998). Naturally occurring orthopoxviruses: potential for recombination with vaccine vectors. J Clin Microbiol. 36(9):2542-7.

    Tryland M, Sandvik T, Hansen H, Haukenes G, Holtet L, Bennett M, Mehl R, Moens U, Olsvik Ø, Traavik T (1998). Characteristics of four cowpox virus isolates from Norway and Sweden. APMIS 106(6):623-35.

    Forskningsinteresser

    Microbiology, Virology, Host-pathogen interactions, Molecular biology and biotechnology

     

    Main research activities

    My recent research has mainly focused on studying quorum sensing (QS) in the marine, pathogenic bacteria Aliivibiro salmonicida. QS is a cell-to-cell signaling system that enables bacterial populations to collectively regulate gene expression in response to cell density and thus coordinate group behaviors. Our study shows that A. salmonicida produces eight different QS signal molecules (N-acyl-homoserine lactones) to regulate activities such as biofilm formation, colony morphology, motility, and virulence amongst others. A. salmonicida causes disease in the Atlantic salmon only during winter seasons when the sea temperature is low, and our studies show that temperature is an important environmental factor for QS in this bacteria.

    The most recent project I have focused on explores the potential of using Arctic, marine bacteria as bioplastics producers. When grow in an environment with nutrient imbalance, many bacteria can store carbon as polyhydroxyalkonates (PHA), a fully biodegradable biopolyester. These carbon storages are visible as large granules in the cytoplasm. Based on the presence of pha synthase genes we have selected and screened different marine proteobacteria for their ability to produce PHA. Several promising candidates have been identified and shown to produce intracellular PHA granules.

    My MSc and PhD work was within the field of virology where I studied orthopoxviruses. The aims were to study distribution of orthopoxviruses within the Norwegian fauna, to characterize cowpox viruses isolated from Fennoscandinavia and to study risks associated with using genetically modified orthopoxviruses as vaccine vectors.

     

    Research projects

    MarPlast (2017-2020) Marine microorganisms for bioplastics production (WP-leader)

    MarVal From unexploited marine biomass to high value products (Researcher)

    ORCID: https://orcid.org/0000-0002-1942-4837