Bilde av Seredkina, Natalya
Bilde av Seredkina, Natalya
Institutt for medisinsk biologi nse000@post.uit.no +4777620937 Tromsø

Natalya Seredkina


Postdoktor

Stillingsbeskrivelse

Forsker i Stem Cell Aging and Cancer Research Group


  • Dhivya Thiyagarajan, Hege Lynum Pedersen, Natalya Seredkina, Kjersti Daae Horvei, Lorena Arranz, Ramon Sonneveld m.fl.:
    IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene
    Frontiers in Cell and Developmental Biology 2018 ARKIV / DOI
  • Hege Lynum Pedersen, Kjersti Daae Horvei, Dhivya Thiyagarajan, Gudrun Norby, Natalya Seredkina, Gabriella Moroni m.fl.:
    Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression
    The journal of pathology. Clinical research 2018 ARKIV / DOI
  • Kjersti Daae Horvei, Hege Lynum Pedersen, Silje Fismen, Dhivya Thiyagarajan, Andrea Schneider, Ole Petter Rekvig m.fl.:
    Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.
    PLOS ONE 2017 ARKIV / DOI
  • Ole Petter Rekvig, Dhivya Thiyagarajan, Hege Lynum Pedersen, Kjersti Daae Horvei, Natalya Seredkina :
    Future perspectives on pathogenesis of Lupus Nephritis: facts, problems, and potential causal therapy modalities
    American Journal of Pathology 2016 DOI
  • Alexander Kashulin, Natalya Seredkina, Henning Sørum :
    Cold-water vibriosis. The current status of knowledge
    Journal of Fish Diseases 2016 DOI
  • Dhivya Thiyagarajan, Ole Petter Rekvig, Natalya Seredkina :
    TNFα amplifies DNaseI expression in renal tubular cells while IL-1β promotes nuclear DNaseI translocation in an endonuclease-inactive form
    PLOS ONE 2015 ARKIV / DOI
  • Hege Lynum Pedersen, Kjersti Daae Horvei, Dhivya Thiyagarajan, Natalya Seredkina, Ole Petter Rekvig :
    Murine and human lupus nephritis: pathogenic mechanisms and theoretical strategies for therapy
    Seminars in Nephrology 2015 DOI
  • Ole Petter Rekvig, Johan van der Vlag, Natalya Seredkina :
    Review: Antinucleosome antibodies: A critical reflection on their specificities and diagnostic impact
    Arthritis and Rheumatism 2014 DOI
  • Natalya Seredkina, Johan van der Vlag, Jo Berden, Elin Synnøve Mortensen, Ole Petter Rekvig :
    Lupus Nephritis: Enigmas, Conflicting Models and an Emerging Concept
    Molecular medicine (Cambridge, Mass. Print) 2013 ARKIV / DOI
  • Silje Fismen, Dhivya Thiyagarajan, Natalya Seredkina, Henrik Nielsen, Søren Jacobsen, Thomas Elung-Jensen m.fl.:
    Impact of the Tumor Necrosis Factor Receptor-Associated Protein 1 (Trap1) on Renal DNaseI Shutdown and on Progression of Murine and Human Lupus Nephritis
    American Journal of Pathology 2013 DOI
  • Dhivya Thiyagarajan, Silje Fismen, Natalya Seredkina, Søren Jacobsen, Thomas Elung-Jensen, Anne-Lise Kamper m.fl.:
    Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e
    PLOS ONE 2012 ARKIV / DOI
  • Natalya Seredkina, Ole Petter Rekvig :
    Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature of murine lupus nephritis
    American Journal of Pathology 2011 DOI
  • Elena Egorina, Mikhail Sovershaev, Vladimir Bogdanov, TA Sovershaev, John T. Fallon, Natalya Seredkina m.fl.:
    Low thrombogenicity of calcified atherosclerotic plaques is associated with bone morphogenetic protein-2-dependent inhibition of tissue factor expression
    Blood Coagulation and Fibrinolysis 2011 DOI
  • Mikhail Sovershaev, Elena Egorina, Vladimir Bogdanov, Natalya Seredkina, JT Fallon, Andrey Yurjevich Valkov m.fl.:
    Bone morphogenetic protein-7 increases thrombogenicity of lipid-rich atherosclerotic plaques via activation of tissue factor
    Thrombosis Research 2010 DOI
  • Kristin Andreassen Fenton, Silje Fismen, Annica Hedberg, Natalya Seredkina, Christopher Graham Fenton, Elin Mortensen m.fl.:
    Anti-dsDNA Antibodies Promote Initiation, and Acquired Loss of Renal Dnase1 Promotes Progression of Lupus Nephritis in Autoimmune (NZBxNZW)F1 mice
    PLOS ONE 2009 ARKIV / DOI
  • Natalya Seredkina, Svetlana Zykova, Ole Petter Rekvik :
    Progression of Murine Lupus Nephritis Is Linked to Acquired Renal Dnase1 Deficiency and Not to Up-Regulated Apoptosis
    American Journal of Pathology 2009 DOI
  • Svetlana Zykova, Natalya Seredkina, Jørgen Benjaminsen, Ole Petter Rekvik :
    Reduced fragmentation of apoptotic chromatin is associated with nephritis in lupus-prone (NZB x NZW)F-1 mice
    Arthritis and Rheumatism 2008 DOI
  • Svetlana Zykova, Natalya Seredkina, Ole Petter Rekvik :
    Glomerular targets for autoantibodies in lupus nephritis - An apoptotic origin
    Annals of the New York Academy of Sciences 2007 DOI
  • Hege Lynum Pedersen, Kjersti Daae Horvei, Dhivya Thiyagarajan, Gudrun Norby, Natalya Seredkina, Gabriella Moroni m.fl.:
    LUPUS NEPHRITIS: SEVERELY REDUCED URINARY DNASE I LEVELS REFLECT LOSS OF RENAL DNASE I, DISEASE PROGRESSION AND MAY REDUCE THE NEED FOR RENAL BIOPSIES
    2018
  • Natalya Seredkina :
    Lupus nephritis: the role of DNase I in the progression of the disease
    2011
  • Natalya Seredkina :
    Reduced renal Dnase1 expression and activity is unique to murine lupus nephritis
    2010
  • Natalya Seredkina, Ole Petter Rekvig :
    Acquired loss of renal Dnase1 is an organ specific feature for severe lupus nephritis
    2010
  • Natalya Seredkina, Svetlana Zykova, Ole Petter Rekvig :
    Analysis of apoptotic activity in lupus nephritis
    2007

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    Publikasjoner utenom Cristin


    1.         Nedashkovsky E.V., M.Y. Kirov, E.M. Egorina, M.A. Sovershaev, N.E. Seredkina and O.V. Evgenov. SAPS II: our experience of use in septic shock [In Russian]. Intensive Care Herald, 1999; 2: 3-7


    Forskningsinteresser

    Immunology
    Systemic lupus erythematosus
    Lupus nephritis


    CV


    Utdanning
    1999     M.D.     Arkhangelsk State Medical Academy, Arkhangelsk, Russia
    2011     Ph.D. in Molecular and Structural Biology      University of Tromsø, Tromsø, Norway

    Yrkespraksis
    1999-2000         Internship        Department of Internal Medicine, Northern State Medical University, Arkhangelsk, Russia
    2000-2002         Clinical fellowship       Department of Internal Medicine, Northern State Medical University, Arkhangelsk, Russia
    2000-2006         Physician        Department of Internal Medicine, Region Clinical Hospital, Arkhangelsk, Russia
    2001-2006         Cardiologist     Department of Cardiology, Region Clinical Hospital, Arkhangelsk, Russia

    Fullstendig CV