Jan-Olof Winberg


Professor


  • Fatema Rahman, Tra-Mi Nguyen, Olayiwola Adekoya, Cristina Campestre, Paolo Tortorella, Ingebrigt Sylte m.fl.:
    Inhibition of bacterial and human zincmetalloproteases by bisphosphonate- and catechol-containing compounds
    Journal of Enzyme Inhibition and Medicinal Chemistry 2021 ARKIV / DOI
  • Fatema Rahman, Imin Wushur, Nabin Malla, Ove Alexander Høgmoen Åstrand, Pål Rongved, Jan-Olof Winberg m.fl.:
    Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases
    Molecules 2021 ARKIV / DOI
  • Rangita Dawadi, Nabin Malla, Beate Hegge, Imin Wushur, Eli Berg, Gunbjørg Svineng m.fl.:
    Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer
    International Journal of Molecular Sciences 2020 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Jan-Olof Winberg :
    Method for Determining Gelatinolytic Activity in Tissue: In Situ Gelatin Zymography
    Methods in molecular biology 2019 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Jan-Olof Winberg :
    Method for Determining Gelatinolytic Activity in Tissue Extracts: Real-Time Gelatin Zymography.
    Methods in molecular biology 2019 ARKIV / DOI
  • Ingebrigt Sylte, Rangita Dawadi, Nabin Malla, Susannah von Hofsten, Tra-Mi Nguyen, Ann Iren Solli m.fl.:
    The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases
    PLOS ONE 2018 ARKIV / DOI
  • Berit Bang, Nabin Malla, Sampada Bhagwat, lisbeth Aasmoe, Jan-Olof Winberg :
    A Sensitive Assay for Proteases in Bioaerosol Samples: Characterization and Quantification of Airborne Proteases in Salmon Industry Work Environments
    Annals of Work Exposures and Health 2018 DOI
  • Elisabeth Øya, Komlavi Anani Afanou, Nabin Malla, Silvio Uhlig, Elin Rolen, Ida Skaar m.fl.:
    Characterization and pro-inflammatory responses of spore and hyphae samples from various mold species
    Indoor Air 2018 ARKIV / DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane de Albuquerque Cavalcanti Jacobsen, Bente Mortensen m.fl.:
    Cleavage of the urokinase receptor (uPAR) on oral cancer cells: Regulation by transforming growth factor - beta1 (TGF-beta1) and potential effects on migration and invasion
    BMC Cancer 2017 ARKIV / DOI
  • Conny Tümmler, Igor Snapkov, Malin Wickström, Ugo Moens, Linda Ljungblad, Maria Elfman m.fl.:
    Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo
    OncoTarget 2017 ARKIV / DOI
  • Stian Sjøli, Elisa Nuti, Caterina Camodeca, Irina Bilto, Armando Rossello, Jan-Olof Winberg m.fl.:
    Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors
    European Journal of Medicinal Chemistry 2016 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Ann Iren Solli, Anne Dragøy Hafstad, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers
    Journal of Cellular Physiology 2015 ARKIV / DOI
  • Imin Wushur, Ingebrigt Sylte, Jan-Olof Winberg :
    The catalytic reaction mechanism of drosophilid alcohol dehydrogenases
    Perspectives in Science 2015 ARKIV / DOI
  • Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja Eriksson Steigen, Robert Hanes m.fl.:
    Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes
    PLOS ONE 2014 ARKIV / DOI
  • Sampada Satchidanand Bhagwat, Anett Kristin Larsen, Jan-Olof Winberg, Ole Morten Seternes, Berit Bang :
    Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line
    Food and Chemical Toxicology (FCT) 2014 DOI
  • Imin Wushur, Jan-Olof Winberg, Ingebrigt Sylte :
    Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase
    Journal of Biomolecular Structure and Dynamics 2014 DOI
  • Olayiwola Adekoya, Stian Sjøli, Imin Wushur, Irina Bilto, Sergio M Marques, M Amelia Santos m.fl.:
    Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors
    European Journal of Medicinal Chemistry 2014 DOI
  • Stian Sjøli, Ann Iren Solli, Øyvind Wilhelm Akselsen, Yang Jiang, Eli Berg, Trond Vidar Hansen m.fl.:
    PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors
    Biochimica et Biophysica Acta 18. juli 2014 DOI
  • Yimingjiang Wuxiuer, Jan-Olof Winberg, Ingebrigt Sylte :
    Comparative molecular dynamics simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase
    Journal of Biomolecular Structure and Dynamics 2013 DOI
  • Nabin Malla, Eli Berg, Achilleas D. Theocharis, Gunbjørg Svineng, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Invitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican
    The FEBS Journal 2013 DOI
  • Ann Iren Solli, Bodil Irene Fadnes, Jan-Olof Winberg, Lars Uhlin-Hansen, Elin Synnøve Hadler-Olsen :
    Tissue- and Cell-Specific Co-localization of Intracellular Gelatinolytic Activity and Matrix Metalloproteinase 2
    Journal of Histochemistry and Cytochemistry 2013 DOI
  • ingvild Pettersen, Ninib Baryawno, Frida Abel, wenche helen Bakkelund, Svetlana Zykova, Jan-Olof Winberg m.fl.:
    Expression of TWEAK/Fn14 in neuroblastoma: Implications in tumorigenesis
    International Journal of Oncology 2013 DOI
  • Elin Synnøve Hadler-Olsen, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets
    Tumour Biology 01. august 2013 DOI
  • Turid Hellevik, ingvild Pettersen, Vivian Berg, Jan-Olof Winberg, Bjørn Torvald Greve Moe, Kristian Bartnes m.fl.:
    Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced
    Radiation Oncology 2012 ARKIV / DOI
  • Bodil Irene Fadnes, Elin Synnøve Hadler-Olsen, Ingebrigt Sylte, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Matrix metalloproteinase complexes and their biological significance
    Walter de Gruyter (De Gruyter) 2012 DOI
  • Yimingjiang Wuxiuer, Ekaterina Morgunova, Neus Cols, Alexander Popov, Andrey Karshikoff, Ingebrigt Sylte m.fl.:
    An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity
    The FEBS Journal 2012 DOI
  • Nabin Malla, Eli Berg, Ugo Moens, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Biosynthesis of Promatrix Metalloproteinase-9/Chondroitin Sulphate Proteoglycan Heteromer Involves a Rottlerin-Sensitive Pathway
    PLOS ONE 2011 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Jan-Olof Winberg, Finn P. Reinholt, Terje Larsen, Lars Uhlin-Hansen, Trond Geir Jenssen m.fl.:
    Proteases in plasma and kidney of db /db mice as markers of diabetes-induced nephropathy
    ISRN Endocrinology 2011 ARKIV / DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, Chandra Sekhar Ravuri, Ahmad Omair, Oddveig G Rikardsen, Gunbjørg Svineng m.fl.:
    Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front
    European Journal of Cancer 2011 DOI
  • Hilde Ljones, Elin Synnøve Hadler-Olsen, Synnøve Magnussen, Oddveig G Rikardsen, sonja eriksson Steigen, elisabeth Sundkvist m.fl.:
    S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment
    American Journal of Pathology 2011 DOI
  • Elin Synnøve Hadler-Olsen, Bodil Irene Fadnes, Ingebrigt Sylte, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Regulation of matrix metalloproteinase activity in health and disease
    The FEBS Journal 2011 DOI
  • Elin Synnøve Hadler-Olsen, Premasany Kanapathippillai, Eli Berg, Gunbjørg Svineng, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Gelatin In Situ Zymography on Fixed, Paraffin-embedded Tissue: Zinc and Ethanol Fixation Preserve Enzyme Activity
    Journal of Histochemistry and Cytochemistry 2010 DOI
  • Fatema Rahman, Imin Wushur, Ingebrigt Sylte, Jan-Olof Winberg :
    Extracellular human and bacterial zinc metalloproteases – challenges in design of specific inhibitors
    NBS-nytt 2021
  • Berit Bang, Anett Kristin Larsen, Sampada Satchidanand Bhagwat, Nabin Malla, Ole Morten Seternes, Jan-Olof Winberg :
    Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.
    2016
  • Berit Bang, Anett Kristin Larsen, Sampada Satchidanand Bhagwat, Nabin Malla, Ole Morten Seternes, Jan-Olof Winberg :
    Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.
    2016
  • Berit Bang, Nabin Malla, Sampada Satchidanand Bhagwat, Merethe Larsen, Jan-Olof Winberg :
    A sensitive assay for proteases in work environmental samples based on zymography.
    2016
  • Anna Maria Wirsing, Ann Iren Solli, Gunbjørg Svineng, Jan-Olof Winberg, Elin Synnøve Hadler-Olsen :
    Intracellular Matrix Metalloproteinase-2 in skeletal muscle: effect of glucose and oxidative stress
    2015
  • Anna Maria Wirsing, Ann Iren Solli, Gunbjørg Svineng, Jan-Olof Winberg, Elin Synnøve Hadler-Olsen :
    Intracellular Matrix Metalloproteinase-2 in skeletal muscle - a 3D skeletal muscle tissue engineering approach -
    2015
  • Ann Iren Solli, Bodil Irene Fadnes, Jan-Olof Winberg, Lars Uhlin-Hansen, Elin Synnøve Hadler-Olsen :
    Intracellular MMP-2 localization and activity
    2013
  • Elin Synnøve Hadler-Olsen, Ann Iren Solli, Anne Dragøy Hafstad, Jan-Olof Winberg, Lars Uhlin-Hansen :
    Intracellular MMP-2 Activity in Skeletal Muscle is Associated with Type II Fibers
    2013
  • Gunbjørg Svineng, Synnøve Magnussen, Elin Synnøve Hadler-Olsen, Nadezhda Latysheva, Emma Pirila, Sonja Eriksson Steigen m.fl.:
    Stromal induced expression of uPAR
    2013
  • Turid Hellevik, ingvild Pettersen, Jan-Olof Winberg, Vivian Berg, Jack-Ansgar Bruun, Bjørn Thorvald Greve Moe m.fl.:
    Consequential effects of ablative ionizing radiation on tumor stromal fibroblasts from lung tumors
    2012
  • Turid Hellevik, ingvild Pettersen, Jan-Olof Winberg, Vivian Berg, Kristian Bartnes, Lill-Tove Busund m.fl.:
    Secretory profile of Cancer-Associated Fibroblasts after exposure to ablative radiation doses: Impact on angiogenesis and tumor growth
    2012
  • Elin Synnøve Hadler-Olsen, Ann Iren Solli, Bodil Irene Fadnes, Lars Uhlin-Hansen, Jan-Olof Winberg :
    Tissue localization of intracellular gelatinolytic activity
    The FEBS Journal 2012
  • Jan-Olof Winberg :
    Matrix proteinases: biological significance in health and disease - Introduction
    Walter de Gruyter (De Gruyter) 2012
  • Turid Hellevik, Inger Pettersen, Jan-Olof Winberg, Vivian Berg, Ruth H Paulssen, Kristian Bartnes m.fl.:
    The Impact of Ionizing Radiation on the Motility and Matrix Remodelling Properties of Carcinoma-associated Fibroblasts
    European Journal of Cancer 2011
  • Elin Synnøve Hadler-Olsen, Chandra Sekhar Ravuri, Hilde Ljones Wetting, Oddveig G Rikardsen, sonja eriksson Steigen, Gunbjørg Svineng m.fl.:
    Stromal Impact on Tumor Invasiveness and Gelatinolytic Activity at the Invasive Front
    2011
  • Elin Synnøve Hadler-Olsen, Chandra Sekhar Ravuri, Hilde Ljones, Oddveig G Rikardsen, sonja eriksson Steigen, Gunbjørg Svineng m.fl.:
    Organ specific stromal influence on tumor invasiveness and proteolytic activity at the invasive front
    European Journal of Cancer 2010 DOI
  • Elin Synnøve Hadler-Olsen, Hilde Ljones, O Rikardsen, sonja eriksson Steigen, Jan-Olof Winberg, Gunbjørg Svineng m.fl.:
    Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts
    APMIS - Journal of Pathologiy, Microbiology and Immunology 2010
  • Yimingjiang Wuxiuer, N Cols, R Gonzalez-Duarte, R Ladenstein, Ingebrigt Sylte, Jan-Olof Winberg :
    Kinetic characterization of the Drosophila lebanonensis ADH T114V mutant
    The FEBS Journal 2010

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    Forskningsinteresser

    Min forskning er fokusert på enzymer, enzymhemmere og strukturproteiner. Disse enzymene og proteinene er normalt involvert i metabolisme, regulering av blodtrykk, utvikling, cellesignalering og den strukturelle integriteten av vev (ekstracellulær matriks). Disse enzymene og proteinene er også involvert i ulike typer av sykdommer slik som kreft, multiple sklerose, artritt og hudsykdommer. Arbeidet er for tilfellet fokusert rundt to hovedgrupper av enzymer, dehydrogenaser og proteinaser. Rensede enzymer studeres for å forstå disse enzymenes virkningsmekanisme, hvordan de kan aktiveres og hemmes, deres substratpreferanser, deres interaksjoner med andre proteiner, rollen til individuelle aminosyrer i katalysen og i interaksjoner med andre molekyler. Vi ser også på uttrykket av disse enzymene i celler og vev for å få en oppfatning om hvordan de reguleres, samt om det er et endret uttrykk av disse enzymene i ulike sykdommer. Målet for våre studier er å generere ny kunnskap som skal kunne brukes til å fremskaffe nye legemidler.