Georg Sager
Professor emeritus / Eksperimentell og Klinisk Farmakologi
Stillingsbeskrivelse
Professor emeritus
Adrina Kalasho,
Anders Lund Selli,
Markus Furuholmen,
Natalia Smaglyukova,
Timofey Kondratyev,
Ole Martin Fuskevåg
m.fl.:
Moderate but not severe hypothermia increases intracellular cyclic AMP through preserved production and reduced elimination
Anders Lund Selli,
Adrina Kalasho,
Natalia Smaglyukova,
Timofey Kondratyev,
Ole Martin Fuskevåg,
Georg Sager
m.fl.:
Pharmacodynamic properties for inhibition of cAMP- and cGMP elimination by pentoxifylline remain unaltered in vitro during hypothermia
Adrina Kalasho,
Anders Lund Selli,
Natalia Smaglyukova,
Timofey Kondratyev,
Ole Martin Fuskevåg,
Roy Andre Lyså
m.fl.:
Treatment of Cardiovascular Dysfunction with PDE3-Inhibitors in Moderate and Severe Hypothermia—Effects on Cellular Elimination of Cyclic Adenosine Monophosphate and Cyclic Guanosine Monophosphate
Anders Lund Selli,
Adrina Kalasho Kuzmiszyn,
Natalia Smaglyukova,
Timofey Kondratyev,
Ole Martin Fuskevåg,
Roy Andre Lyså
m.fl.:
Treatment of cardiovascular dysfunction with PDE5-inhibitors - temperature dependent effects on transport and metabolism of cAMP and cGMP
Sondre Ulstein Odland,
Aina Westrheim Ravna,
Natalia Smaglyukova,
Erik Sveberg Dietrichs,
Georg Sager
:
Inhibition of ABCC5-mediated cGMP transport by progesterone, testosterone and their analogues
Ingmar Trane,
Georg Sager,
Erik Sveberg Dietrichs,
Aina Westrheim Ravna
:
Molecular modeling study of the testosterone metabolizing enzyme UDP-glucuronosyltransferase 2B17
Siri Amundsen,
Hedvig Marie Egeland Nordeng,
Ole Martin Fuskevåg,
Elisabet N Nordmo,
Georg Sager,
Olav Spigset
:
Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding
Natalia Smaglyukova,
Elise Thoresen Sletten,
Anne Ørbo,
Georg Sager
:
Data on RT-qPCR assay of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) from human uterine endometrial tissue and cancer cells of the uterine cervix
Elise Thoresen Sletten,
Natalia Smaglyukova,
Anne Ørbo,
Georg Sager
:
Expression of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) in the human endometrium after 6 months levonorgestrel low dose intrauterine therapy,
Farzane Kuresh Kashgari,
Aina Westrheim Ravna,
Georg Sager,
Roy Andre Lyså,
Istvan Enyedy,
Erik Sveberg Dietrichs
:
Identification and experimental confirmation of novel cGMP efflux inhibitors by virtual ligand screening of vardenafil-analogues
Georg Sager,
Natalia Smaglyukova,
Ole-Martin Fuskevåg
:
The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes
Journal of Cellular Physiology 2018 DOI
Anna Subbotina,
Aina Westrheim Ravna,
Roy Andre Lyså,
Ruben Abagyan,
Ryszard Bugno,
Georg Sager
:
Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux
Erik Sveberg Dietrichs,
Georg Sager,
Torkjel Tveita
:
Altered pharmacological effects of adrenergic agonists during hypothermia
Xiaoyan Chen,
Roy Lysaa,
Ragnhild Jaeger,
Emmanuel Boadu,
Georg Sager
:
The effect of MRP5-expression on human erythroleukemia (HEL) cell growth and cGMP levels
Pharmacology and Pharmacy 2016 DOI
Erik Sveberg Dietrichs,
Torstein Schanche,
Timofey Kondratyev,
Svein Erik Gaustad,
Georg Sager,
Torkjel Tveita
:
Negative inotropic effects of epinephrine in the presence of increased β-adrenoceptor sensitivity during hypothermia in a rat model
Cryobiology 2015 DOI
Georg Sager,
Elisabeth Sundkvist,
Ragnhild Jæger,
Roy Andre Lyså,
Ole-Martin Fuskevåg,
Ole-Martin Fuskevåg
:
Sodium nitroprusside inhibits HEK293 cell growth by cGMP-dependent and independent mechanisms
Lena Aronsen,
Elin Peggy Hanne Øien Ørvoll,
Roy Andre Lyså,
Aina Westrheim Ravna,
Georg Sager
:
Modulation of high affinity ATP-dependent cyclic nucleotide transporters by specific and non-specific cyclic nucleotide phosphodiesterase inhibitors
elin peggy hanne Øien Ørvoll,
Roy Andre Lyså,
aina westrheim Ravna,
Georg Sager
:
Misoprostol and the sildenafil analog (PHAR- 0099048) modulate cellular efflux of cAMP and cGMP differently
Pharmacology and Pharmacy 30. januar 2013 DOI
Georg Sager,
elin peggy hanne Øien Ørvoll,
Roy Andre Lyså,
Irina Kufareva,
Ruben Abagyan,
aina westrheim Ravna
:
Novel cGMP Efflux Inhibitors Identified by Virtual Ligand Screening (VLS) and Confirmed by Experimental Studies
Journal of Medicinal Chemistry 2012 DOI
Tormod Eggen,
Georg Sager,
Thomas Berg,
Birgitte Nergaard,
Bjørn Torvald Greve Moe,
Anne Ørbo
:
Increased Gene Expression of the ABCC5 Transporter without Distinct Changes in the Expression of PDE5 in Human Cervical Cancer Cells during Growth
Anticancer Research 2012 FULLTEKST
Ole Magnus Filseth,
Ole-Jakob How,
Timofey Kondratyev,
Tor Magne Gamst,
Georg Sager,
Torkjel Tveita
:
Changes in cardiovascular effects of dopamine in response to graded hypothermia in vivo
Critical Care Medicine 2012 DOI
Tormod Eggen,
Georg Sager,
Marit Arnes,
Inger Pettersen,
Anne Ørbo
:
Expression of iNOS - A Favourable Prognostic Marker for Early-stage Carcinoma of the Uterine Cervix
Anticancer Research 2011
Arne Martin Slåtsve,
aina westrheim Ravna,
Roy Andre Lyså,
Georg Sager
:
ABC-transportørenes betydning for effekt og omsetning av legemidler
Tidsskrift for Den norske legeforening 2011 DOI
Renathe Fjelldal,
Bjørn Torvald Greve Moe,
Anne Ørbo,
Georg Sager
:
MCF-7 Cell Apoptosis and Cell Cycle Arrest: Non-genomic Effects of Progesterone and Mifepristone (RU-486)
Anticancer Research 2010
aina westrheim Ravna,
Georg Sager,
Svein G. Dahl,
Ingebrigt Sylte
:
Membrane transporters: Structure, function and targets for drug design
Springer Publishing Company 2009
aina westrheim Ravna,
Ingebrigt Sylte,
Georg Sager
:
Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure
Theoretical Biology Medical Modelling 2009 DOI
Bjørn Torvald Greve Moe,
Anne Beate Vereide,
Anne Ørbo,
ragnhild JÆger,
Georg Sager
:
Levonorgestrel, Medroxyprogesterone and Progesterone Cause a Concentration-dependent Reduction in Endometrial Cancer (Ishikawa) Cell Density, and High Concentrations of Progesterone and Mifepristone Act in Synergy
Anticancer Research 2009
aina westrheim Ravna,
Georg Sager
:
Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance
Mini-Reviews in Medicinal Chemistry 2009
Georg Sager,
aina westrheim Ravna
:
Cellular Efflux of cAMP and cGMP - A Question about Selectivity
Mini-Reviews in Medicinal Chemistry 2009
Bjørn Torvald Greve Moe,
Anne Beate Vereide,
Anne Ørbo,
Georg Sager
:
High Concentrations of Progesterone and Mifepristone Mutually Reinforce Cell Cycle Retardation and Induction of Apoptosis
Anticancer Research 2009
aina westrheim Ravna,
Georg Sager
:
Molecular model of the outward facing state of the human multidrug resistance protein 4 (MRP4/ABCC4)
Bioorganic & Medicinal Chemistry Letters 2008 DOI
aina westrheim Ravna,
Ingebrigt Sylte,
Georg Sager
:
A molecular model of a putative substrate releasing conformation of multidrug resistance protein 5 (MRP5)
European Journal of Medicinal Chemistry 2008 DOI
Stig Müller,
Ole-Jakob How,
Stig eggen Hermansen,
Thor Allan Stenberg,
Georg Sager,
truls Myrmel
:
Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia
Critical Care 2008 DOI
Anne Ørbo,
Målfrid Hanevik,
ragnhild JÆger,
Saskia Van Heusden,
Georg Sager
:
Urinary cyclic GMP after treatment of gynecological cancer. A prognostic marker of clinical outcome
Anticancer Research 2007
aina westrheim Ravna,
Ingebrigt Sylte,
Georg Sager
:
Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)
Theoretical Biology Medical Modelling 2007
Anne Beate Vereide,
Turid Kaino,
Georg Sager,
Marit Arnes,
Anne Ørbo
:
Effect of levonorgestrel IUD and oral medroxyprogesterone acetate on glandular and stromal progesterone receptors (PRA and PRB), and estrogen receptors (ER-alpha and ER-beta) in human endometrial hyperplasia
Gynecologic Oncology 2006
Farzane Kuresh Kashgari,
Aina Westrheim Ravna,
Georg Sager,
Roy Andre Lyså,
Istvan Enyedy,
Erik Sveberg Dietrichs
:
Corrigendum to “Identification and experimental confirmation of novel cGMP efflux inhibitors by virtual ligand screening of vardenafil-analogues” [Biomed. Pharmacother. 126 (2020) 110109](S0753332220303012)(10.1016/j.biopha.2020.110109)
Biomedicine & Pharmacotherapy 2022 DOI
Tetyana Voloshyna,
Natalia Smaglyukova,
Timofei Kondratiev,
Roy Andre Lyså,
Ole Martin Fuskevåg,
Aina Westrheim Ravna
m.fl.:
Effects of perfluorosulfonic acids on P-glycoprotein mediated transport in the intestinal epithelial barrier
2022
Aina Westrheim Ravna,
Georg Sager
:
Lørdagsuniversitetet: Drug design på data’n
2017
Aina Westrheim Ravna,
Georg Sager,
Ole-Martin Fuskevåg
:
Når kjemien stemmer
26. september 2017
Ingebrigt Sylte,
Georg Sager
:
En pionerforsker
Ottar 2013 ARKIV
Camilla Larsen,
Georg Sager
:
Rasjonell og sikker farmakoterapi for eldre
Tidsskrift for Den norske legeforening 2013 DOI
Erik Sveberg Dietrichs,
Svein Erik Gaustad,
T Kondratiev,
Georg Sager,
Torkjel Tveita
:
Hypothermia-induced dysfunction of the myocardial B1-adrenoceptor signal system
2012
Bjørn Thorvald Greve Moe,
Anne Ørbo,
Georg Sager,
Anne Beate Vereide
:
Extranuclear steroid-initiated signaling by progestin and mifepristone: concentration-dependent inhibition of Ishikawa cell proliferation and induction of apoptosis
Virchows Archiv 2011
Georg Sager,
Marit Livik,
Turid Hellevik,
Oddvar Spanne,
Bjørn Thorvald Greve Moe
:
Radiation sensitivity of cancer cervicis cells (C4-1) and extracellular cyclic GMP as a biomarker of radiation effect.
2010
OM Filseth,
Ole-Jakob How,
Timofei Kondratiev,
Tor Magne Gamst,
Georg Sager,
Torkjel Tveita
:
DOPAMINE INFUSIONS IN NORMOTHERMIA, SEVERE HYPOTHERMIA AND DURING REWARMING: PHARMACOKINETICS AND CARDIOVASCULAR FUNCTION IN A PIG MODEL OF SURFACE COOLING AND REWARMING
Intensive Care Medicine 2010
Anne Ørbo,
Bjørn greve Moe,
Georg Sager,
Anne Beate Vereide
:
Extranuclear steroid-initiated signaling by progestin and mifepristone
2007
Anne Ørbo,
Turid Kaino,
Georg Sager,
Marit Arnes
:
Bcl-2, BAX and apoptosis in endometrial hyperplasia after high dose gestagen therapy A comparison of responses in patients treated with intrauterine levonorgestrel and systemic medroxyprogesterone
2007
Bjørn greve Moe,
Anne Beate Vereide,
Anne Ørbo,
Georg Sager
:
Extranuclear steroid-initiated signaling by progestin and mifepristone: Concentration dependent inhibition of Ishikawa cell proliferation and induction of apoptosis
Virchows Archiv 2007
Georg Sager
:
Organic anion transporters, primary and tertiary transport
2005
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Forskningsinteresser
Eksperimentell og klinisk farmakologi med vekt på legemiddelbehandling av kreftsykdommer.
Nåværende forskning: ABC-transportere - Biologi og farmakologi med vinkling mot kreftsykdommer.
Tidligere forskning: Plasma protein binding av legemidler, regulering og funksjon av beta-adrenerge reseptorer.
Medlem i forskningsgruppe
Medlem i prosjekt
Transport of drugs and signal molecules across cell membranes
Pharmacological treatment of hypothermia-induced cardiac dysfunction
Extracellular cyclic cGMP as a biomarker for effect of treatment (cytotoxic drugs and radiation) on gynecologic cancers
Non-genomic progesterone receptors including membrane GPCR (mPR) and PGRMC (progesterone receptor membrane components)