Publikasjoner

2012

Wuxiuer Y, Morgunova E, Cols N, Popov A, Karshikoff A, Sylte I, Gonzàlez-Duarte R, Ladenstein R & Winberg JO. An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity. FEBS J 279: 2940-2956, 2012.

Hellevik T, Pettersen I, Beg V, Winberg JO, Moe TB, Bartnes K, Paulssen RH, Busund LT, Bremnes R, Chalmers A & Martinez-Zubiaurre I. Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced. Radiation Oncology, 7: 59, 2012).

Winberg JO. Extracellular proteinases: biological significance in health and disease - Introduction. In Extracellular matrix: pathobiology and signaling, chapter 4.1 p. 233-238, Karamanos N (ed), Gullberg D, Heldin P, Schaefer L, Theocharis A, Tenni R & Winberg JO (Co-eds), De Gruyter, Berlin, Germany, 2012. ISBN: 978-3-11-025877-6.

Fadnes B, Hadler-Olsen E, Sylte I, Uhlin-Hansen L, Winberg JO. Extracellular proteinases: biological significance in health and disease - Matrix metalloproteinase complexes and their biological significance. In Extracellular matrix: pathobiology and signaling, chapter 4.4 p. 291-314, Karamanos N (ed), Gullberg D, Heldin P, Schaefer L, Theocharis A, Tenni R & Winberg JO (Co-eds), De Gruyter, Berlin, Germany, 2012. ISBN: 978-3-11-025877-6.

Svineng G, Magnussen S, Hadler-Olsen E. Extracellular proteinases: biological significance in health and disease - Plasmin and the plasminogen activator system in health and disease. In Extracellular matrix: pathobiology and signaling, chapter 4.3 p.  261-290, Karamanos N (ed), Gullberg D, Heldin P, Schaefer L, Theocharis A, Tenni R & Winberg JO (Co-eds), De Gruyter, Berlin, Germany, 2012. ISBN: 978-3-11-025877-6.

Ausbacher D, Svineng G, Hansen T, Strøm MB. Anticancer mechanisms of action of two small amphipathic β(2,2)-amino acid derivatives derived from antimicrobial peptides. Biochim Biophys Acta 1818: 2917-2925, 2012.

Fadnes B, Husebekk A, Svineng G, Rekdal Ø, Yanagishita M, Kolset SO, Uhlin-Hansen L. The proteoglycan repertoire of lymphoid cells. Glycoconj J In press: Jul 10, 2012.

Edris B, Espinosa I, Mühlenberg T, Mikels A, Lee CH, Steigen SE, Zhu S, Montgomery KD, Lazar AJ, Lev D, Fletcher JA, Beck AH, West RB, Nusse R, van de Rijn M. ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour. J Pathol 227: 223-33, 2012.

Joensuu H, Vehtari A, Riihimäki J, Nishida T, Steigen SE, Brabec P, Plank L, Nilsson B, Cirilli C, Braconi C, Bordoni A, Magnusson MK, Linke Z, Sufliarsky J, Federico M, Jonasson JG, Dei Tos AP, Rutkowski P. Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol 13: 265-74, 2012.

Stensland HFR, Klenow HB, Van Nguyen L; Hansen G, Malm D; Nilssen Ø. Identification of 83 novel alpha-mannosidosis-associated sequence variants: Functional analysis of MAN2B1 missense mutations. Human Mutation 33: 511-20, 2012.

2011

Hadler-Olsen E, Fadnes B, Sylte I, Uhlin-Hansen L, Winberg J.O. Regulation of matrix metalloproteinases in health and disease. FEBS J 278: 28-45, 2011 (invited minireview). 

Hadler-Olsen E, Wetting HL, Ravuri C, Omair A, Rikardsen O, Svineng G, Kanapathippillai P, Winberg JO, Uhlin-Hansen L. Organ specific regulation of tumor invasiveness and gelatinolytic activity at the invasive front. Eur J Cancer 47: 305-315, 2011. 

Wetting HL, Hadler-Olsen E, Magnussen S, Rikardsen O, Steigen SE, Sundkvist E, Loennechen T, Kanapathippillai P, Kildalsen H, Winberg JO, Uhlin-Hansen L, Svineng G. S100A4 expression in xenografts of human carcinoma cell lines is induced by the tumor microenvironment.   Am J Pathol 178: 2389-2396 (+ supplement), 2011.

Malla N, Berg E, Moens U, Uhlin-Hansen L, Winberg JO. Biosynthesis of proMatrix Metalloproteinase-9/Chondroitin Sulfate Proteoglycan heterodimer involves a rottlerin-sensitive pathway. PLoS ONE 6 (6), e20616 (p. 1-14), 2011.

Hadler-Olsen E, Winberg JO, Reinholt F, Larsen T, Uhlin-Hansen L, Jenssen T, Berg E, Kolset SO. Proteases in plasma and kidney of db/db mice as markers of diabetes-induced nephropathy. ISRN Endocrinology, Article ID 832642, 1-10, 2011.

Ausbacher D, Hansen T, Svineng G, Strøm MB. Mechanisms of Cancer Cell Death Induced by Two Novel Cationic β-Peptidomimetics. Proceedings of the 22nd American Peptide Symposium Michal Lebl (Editor) American Peptide Society, 2011

Fadnes B, Uhlin-Hansen L, Lindin I & Rekdal Ø. Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells. BMC Cancer 11: 116, 2011. (Nivå 1).

Meknas K, Johansen O, Steigen SE, Olsen R, Jørgensen L, Kartus J. Could tendinosis be involved in osteoarthritis? Scand J Med Sci Sports. Mar 16. doi: 10.1111/j.1600-0838.2010.01287.x. [Epub ahead of print]

Ljones Wetting H, Hadler-Olsen E, Magnussen S, Rikardsen O, Steigen SE, Sundkvist E, Loennechen T, Kanapathippillai P,  Kildalsen H, Winberg JO, Uhlin-Hansen L & Svineng G. S100A4 expression in xenografts of human carcinoma cell lines is induced by the tumor microenvironment. Am J Pathol, 2011; 178(5):2389-96

Hadler-Olsen E, Fadnes B, Sylte I, Uhlin-Hansen L & Winberg J.O. Metalloproteinases in health and disease: Regulation of matrix metalloproteinase activity. FEBS J.:278(1):28-45,2011.

Hadler-Olsen E, Ljones Wetting H, Ravuri C, Omair A, Rikardsen O, Svineng G, Kanapathippillai P, Winberg JO & Uhlin-Hansen L. Organ specific regulation of tumor invasiveness and gelatinolytic activity at the invasive front. Eur J Cancer, 47(2):305-15, 2011

Florholmen J, Kristiansen MG, Steigen SE, Sørbye SW, Paulssen EJ, Kvamme JM, Konopski Z, Gutteberg T, Goll R. A rapid chemokine response of MIP-1alpha, MIP-1beta and RANTES is associated with a sustained virological response in the treatment of chronic hepatitis C. Clin Microbiol Infect.:17(2):204-9, 2011

Ravuri C. Svineng G, Pankiv, S Huseby NE. Endogenous production of reactive oxygen species by the NADPH oxidase complexes is a determinant of γ-glutamyltransferase expression. Free Radical Research, 45(5): 600-10, 2011.

2010

Hadler-Olsen E, Kanapathippipillai P, Berg E, Svineng G, Winberg JO & Uhlin-Hansen L. Gelatin in situ zymography on fixed, paraffi embedded tissue - zinc and ethanol fixation preserve the enzyme activity. J Histochem Cytochem. 2010 Jan;58(1):29-39.  

Berge G, Eliassen LT, Camilio KA, Bartnes K, Sveinbjørnsson B, Rekdal O. Therapeutic vaccination against a murine lymphoma by intratumoral injection of a cationic anticancer peptide. Cancer Immunol Immunother. 2010 Aug;59(8):1285-94.

Florholmen J, Kristiansen MG, Steigen SE, Sørbye SW, Paulssen EJ, Kvamme JM, Konopski Z, Gutteberg T, Goll R. A rapid chemokine response of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta and the regulated on activation, normal T expressed and secreted chemokine is associated with a sustained virological response in the treatment of chronic hepatitis C. Clin Microbiol Infect. 2010 Mar 6.

Hadler-Olsen E, Ljones Wetting H, Rikardsen O, Steigen S, Kanapathippillai P, Grénman R, Winberg JO, Svineng G & Uhlin-Hansen L. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Virchows Archiv. 457(6):677-92, 2010.

2009

Elenjord R, Allen JB, Johansen HT, Kildalsen H, Svineng G, Mælandsmo GM, Loennechen T & Winberg JO. Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4. FEBS Journal 276(18): 5275-5286, 2009.

Huseby NE, Sundkvist E & Svineng G. Glutathione and sulphur containing amino acids: antioxidant and conjugation activities. In: Glutathione and sulphur amino acids in human health and diseases, Masella R, Mazza G eds, John Wiley & Sons: p. 93-120, 2009.

Larsen AN, Solstad T, Svineng G, Seppola M & Jørgensen T. The goose-type lysozyme in Atlantic cod (Gadus morhua L.); expression and genetic characterization. Fish Shellfish Immunol 26:122-32, 2009.

Fadnes B, Rekdal Ø & Uhlin-Hansen L. The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells. BMC Cancer  9: 183, 2009.

Gharagozlian S, Svennevig K, Bangstad HJ, Winberg JO, Kolset SO. Matrix metalloproteinases in subjects with type 1 diabetes. BMC Clin Pathol. Sep 16;9:7, 2009.

Asfeldt AM, Steigen SE, Løchen ML, Straume B, Johnsen R, Bernersen B, Florholmen J, Paulssen EJ. The natural course of Helicobacter pylori infection on endoscopic findings in a population during 17 years of follow-up: the Sørreisa gastrointestinal disorder study. Eur J Epidemiol, Jul 21. 2009.

Steigen SE, Schaeffer DF, West RB, Nielsen TO. Expression of insulin-like growth factor 2 in mesenchymal neoplasms. Mod Pathol 22:914-21, 2009.

Steigen SE, Eide TJ. Gastrointestinal stromal tumors (GISTs): a review. APMIS 117:73-86, 2009 (Review).

Gani OABSM, Adekoya OA, Giurato L, Spyrakis F, Cozzini P, Guccione S, Winberg JO & Sylte I. Theoretical calculations of the catalytic triad in short chain dehydrogenases/reductases.  Biophys J 94: 1412-1427, 2008.

Malla N, Berg E, Uhlin-Hansen L & Winberg JO. Interaction of proMatrix Metalloproteinase-9/Proteoglycan heteromer with Gelatin and Collagen. J Biol Chem 283: 13652-13665, 2008.

Malla N, Sjøli S, Winberg JO, Hadler-Olsen E & Uhlin-Hansen L. Biological and pathobiological functions of gelatinase dimers and complexes. Connective Tissue Research 49: 180-184, 2008 (invited mini-review).

Elenjord R, Ljones H, Sunkvist E, Loennechen T & Winberg JO. Dysregulation of matrix metalloproteinases and their tissue inhibitors by S100A4. Connective Tissue Research 49: 185-188, 2008 (invited mini-review).

Svineng G, Ravuri CS, Rikardsen O, Huseby NE & Winberg JO. The role of reactive oxygen species in integrin and matrix metalloproteinase expression and function. Connective Tissue Research 49: 197-202, 2008 (invited mini-review).

Ladenstein R, Winberg JO & Benach J. Structure-function relationships in alcohol short-chain dehydrogenases. Cell Mol Life Sci 65: 3918-3935, 2008 (invited mini-review).

Haug BE, Stensen W, Kalaaji M, Rekdal Ø & Svendsen JS. Synthetic antimicrobial peptidometics with therapeutic potential. J Med Chem 51: 4306-4314, 2008.

Stensvåg K, Haug T, Sperstad SV, Rekdal Ø, Indrevoll B & Styrvold OB. Arasin 1, a prolin-arginine-rich antimicrobial peptide isolated from the spider crab, Hyas araneus. Dev Comp Immunol 32: 275-285, 2008.

Yuan A, Steigen SE, Goll R, Vonen B, Husbekk A, Cui G, Florholmen J. Dendritic cell infiltration pattern along the colorectal adenoma-carcinoma sequence. APMIS 116:445-56. 2008.

Lasota J, Kuban W, Wardelmann E, Debiec-Rychter M, Merkelbach-Bruse S, Sciot R, Rys J, Steigen SE, Iwanik K, Holden JA, Jerzak Vel Dobosz A, Schildhaus HU, Miettinen M. KIT codon 558 insertions in gastrointestinal stromal tumors. Analysis of 17 rare KIT mutants. Hum Pathol 39: 1728-1736, 2008.

Asfeldt AM, Straume B, Steigen SE, Løchen ML, Florholmen J, Bernersen B, Johnsen R, Paulssen EJ.Changes in the prevalence of dyspepsia and Helicobacter pylori infection after 17 years: The Sørreisa gastrointestinal disorder study. Eur J Epidemiol 23:625-33, 2008.

Berg T, Steigen SE. DNA methylation in breast and colorectal cancer. Mod Pathol. 21: author reply 1063-4. 2008.

Lasota J, Corless CL, Heinrich MC, Debiec-Rychter M, Sciot R, Wardelmann E, Merkelbach-Bruse S, Schildhaus HU, Steigen SE, Stachura J, Wozniak A, Antonescu C, Daum O, Martin J, Del Muro JG, Miettinen M. Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases. Mod Pathol 21:476-84, 2008.

Steigen SE, Straume B, Turbin D, Chan AK, Leung S, Nielsen TO, Lindal S. Clinicopathologic factors and nuclear morphometry as independent prognosticators in KIT-positive gastrointestinal stromal tumors. J Histochem Cytochem 56:139-45, 2008.

Steigen SE, Bjerkehagen B, Haugland HK, Nordrum IS, Løberg EM, Isaksen V, Eide TJ, Nielsen TO. Diagnostic and prognostic markers for gastrointestinal stromal tumors in Norway. Mod Pathol 21:46-53, 2008.

Stensland HFR, Persichetti  E, Sorriso C, Hansen G, Bibi L, Paciotti S, Balducci C, Beccari, T. Identification of two novel beta-mannosidosis-associated sequence variants: Biochemical analysis of beta-mannosidase (MANBA) missense mutations. Molecular Genetics and Metabolism 94: 476 - 480, 2008.

Winberg JO. Kinetic characterization of alcohol dehydrogenases and matrix metalloproteinases: A reflection on standardization of assay conditions. In Experimental Standard Conditions of Enzyme Characterizations 2, Hicks MG & Kettner C eds, Beilstein Institute / Logos-Verlag, Berlin: p.255-270, 2007.

Pandur S, Pankiv S, Johannessen M, Moens U & Huseby NE. Gamma-glutamyltransferase is upregulated after oxidative stress through the Ras signal transduction pathway in rat colon carcinoma cells. Free Radic Res 41:1376-84, 2007.

Sjøttem E, Rekdal C, Svineng G, Johnsen SS, Klenow H, Uglehus R & Johansen T.  The ePHD protein SPBP interacts with TopBP1 to enable synergistic stimulation of Ets1-mediated transcription. Nucl Acids Res 35: 6648-6662, 2007.

Lasota J, Vel Dobosz AJ, Wasag B, Wozniak A, Kraszewska E, Michej W, Ptaszynski K, Rutkowski P, Sarlomo-Rikala M, Steigen SE, Schneider-Stock R, Stachura J, Chosia M, Ogun G, Ruka W, Siedlecki JA, Miettinen M. Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors. Lab Invest 87: 1029-41, 2007.

Steigen SE, Eide TJ, Wasag B, Lasota J, Miettinen M. Mutations in gastrointestinal stromal tumors – a population based study from Northern Norway. APMIS 115: 289-98, 2007.

Cui G, Goll R, Olsen T, Steigen SE, Husebekk A, Vonen B, Florholmen J. Reduced expression of microenvironmental Th1 cytokines accompanies adenomas-carcinomas sequence of colorectum. Cancer Immunol Immunother 56: 985-95, 2007.

Lasota J, Wasag B, Steigen SE, Limon J, Miettinen M. Improved detection of KIT exon 11 duplications in formalin fixed paraffin embedded gastrointestinal stromal tumors (GISTs). J Mol Diagn 9: 89-94, 2007.

2006

Mathisen B, Loennechen T, Gedde-Dahl T & Winberg JO. Fibroblast heterogeneity in collagenolytic response to Colchicine. Biochem Pharmacol 71: 574-583, 2006.

Zernichow L, Dalen KT, Prydz K, Winberg JO & Kolset SO. Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells. FEBS Journal 273: 536-547, 2006.

Pankiv S, Møller S, Moens U, Bjørkøy G & Huseby NE. Radiation-induced upregulation of γ-glutamyltransferase in colon carcinoma CC531 cells is mediated through the Ras signal transduction pathway. Biochim Biophys Acta 1760: 151-7, 2006.

Schibli DJ, Nguyen LT, Kernaghan SD, Rekdal Ø, Vogel HJ. Structure-function analysis of tritrpticin analogs: potential relationships between antimicrobial activities, model membrane interactions, and their micelle-bound NMR structures. Biophys J. 2006 Dec 15;91(12):4413-26. 

Jenssen H, Gutteberg TJ, Rekdal Ø & Lejon T. Prediction of activity, synthesis and biological testing of anti-HSV active peptides. Chem Biol Drug 68: 58-66, 2006.

Eliassen LT, Berge G, Leknessund A, Wikman M, Lindin I, Løkke C, Ponthan F, Johnsen JI, Sveinbjørnsson B, Kogner P, Flegstad T & Rekdal Ø. The antimicrobial peptide, lactoferricin B is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo. Int J Cancer 119: 493-500, 2006.

Falkowska-Hansen B, Øynebråten I, Uhlin-Hansen L & Smedsrød, B. Endocytosis and degradation of serglycin in liver sinusoidal endothelial cells. Mol Cell Biochem 287: 43-52, 2006.

Steigen SE, Steigen TK, Gunnes P, Thuesen L, Mannsverk J, Jørgensen L. Histopathology of material captured by embolic protection device after percutaneous coronary interventions in atherosclerotic saphenous vein grafts. EuroInterv: 244-249, 2006.

Steigen SE, Eide TJ. Trends in incidence and survival of mesenchymal neoplasm of the digestive tract within a defined population of northern Norway. APMIS  114:192-200, 2006.

2005

Benach J, Winberg JO, Svendsen JS, Atrian S, Gonzalez-Duarte R & Ladenstein R.  Drosophila alcohol dehydrogenase: Acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis.  J Mol Biol 345: 579 - 598, 2005.

Tchougounova E, Lundequist A, Fajardo I, Winberg JO, Åbrink M & Pejler G. A key role for mast cell chymase in the activation of pro-matrix metalloproteinase-9 and -2. J Biol Chem 280: 9291-9296,  2005.

Lindstad RI, Sylte I, Mikalsen SO, Seglen PO, Berg E & Winberg JO. Pancreatic trypsin activates human promatrix metalloproteinase-2. J Mol Biol 350: 682-698, 2005.

Foyn Bruun C, Langbakk B, Steigen SE. Purpura fulminans as a sequel to erythema nodosum in a child with homozygous Leiden mutation and acquired protein S deficiency. Acta Paediatr 94:1155-8, 2005.

2004

Lødemel JB, Mæhre HK, Winberg JO & Olsen RL. Tissue distribution, inhibition and activation of gelatinolytic activities in Atlantic cod (Gadus morhua). Comp Biochem Physiol B Biochem Mol Biol 137: 363-371, 2004.

Li X, Mikkelsen IM, Mortensen B, Winberg JO & Huseby NE. Butyrate reduces the invasive growth of rat colon carcinoma cells and their resistance to oxidative stress in vitro. Clin Exp Metastasis 21: 331-338, 2004.

Yang N, Strøm MB, Mekonnen SM, Svendsen JS, Rekdal O. The effects of shortening lactoferrin derived peptides against tumour cells, bacteria and normal human cells. J Pept Sci 10: 37-46, 2004.

Jenssen H, Andersen JH, Uhlin-Hansen L, Gutteberg TJ & Rekdal Ø. Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparin sulphate. Antiviral Res 61:101-109, 2004.

Asfeldt AM, Lochen ML, Straume B, Steigen SE, Florholmen J, Goll R et al. Accuracy of a monoclonal antibody-based stool antigen test in the diagnosis of Helicobacter pylori infection. Scand J Gastroenterol 39:1073-1077, 2004.