Guest lecture by professor Olga Troyanskaya (Princeton University)
There will be a guest lecture by Olga Troyanskaya (Princeton University) on Wednesday 15th of August from 13:15 to 14:00 at Lille Aud, Realfagsbygget.
You are all invited to attend a guest lecture by Professor Olga Troyanskaya (Princeton University) on Wednesday 15th of August from 13:15 to 14:00 at Lille Aud, Realfagsbygget.
Title: Integrative analysis of functional genomics data: from yeast to tissue-specific modeling of human disease.
Abstract: The ongoing explosion of new technologies in functional genomics offers the promise of understanding gene function, interactions, and regulation at the systems level. This should enable us to develop comprehensive descriptions of genetic systems of cellular controls, including those whose malfunctioning becomes the basis of genetic disorders, such as cancer, and others whose failure might produce developmental defects in model systems. However, the complexity and scale of human molecular biology make it difficult to integrate this body of data, understand it on a systems level, and apply it to the study of specific pathways or genetic disorders. These challenges are further exacerbated by the biological complexity of metazoans, including diverse biological processes, individual tissue types and cell lineages, and by the increasingly large scale of data in higher organisms.
I will describe how we address these challenges through the development of bioinformatics frameworks for the study of gene function and regulation in complex biological systems and through close coupling of these methods with experiments, thereby contributing to understanding of human disease. I will specifically discuss how integrated analysis of functional genomics data can be leveraged to study cell-lineage specific gene expression, to identify proteins involved in disease in a way complementary to quantitative genetics approaches, and to direct both large-scale and traditional biological experiments.
Biography: Olga Troyanskaya is an Associate Professor in the Lewis-Sigler Institute for Integrative Genomics and the Department of Computer Science at Princeton University, USA, where she runs the Laboratory of Bioinformatics and Functional Genomics. Her work bridges computer science and molecular biology in an effort to develop better methods for analysis of diverse genomic data with the goal of understanding and modeling protein function and interactions in biological pathways. Her group includes computational and experimental aspects, and tackles diverse questions including developing integrative technologies for pathway prediction and the study of biological networks in complex human disease. Dr. Troyanskaya is an Associate Editor for Bioinformatics, PLOS Computational Biology, and editorial board member of Journal of Biomedical Informatics, Briefings in Bioinformatics, and Biology Direct. She is also a member of the Board of Directors of the International Society for Computational Biology. She received her Ph.D. from Stanford University and is a recipient of the Sloan Research Fellowship, the NSF CAREER award, the Howard Wentz faculty award, and the Blavatnik Finalist Award. She has also been honored as one of the top young technology innovators by the MIT Technology Review and is the 2011 recipient of the Overton Prize in computational biology.
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