Engelsk personkortAusbacher, Dominik
- Antimicrobial/anticancer peptides
- Cell assays and assay development
- Flow cytometry
- Scanning and transmission electron microscopy
Potency, selectivity and mechanistic studies of small antimicrobial and anticancer peptidomimetics
Abstracts:
Leena Pohjala, Dominik Ausbacher, Morten B. Strøm, Pia M. Vuorela. Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides. 7th meeting of the European society for Chlamydia research, Amsterdam (2012).
Dominik Ausbacher, Janni Kujala, Pia M. Vuorela, Morten B. Strøm, Adyary Fallarero. Control of Staphylococcus aureus biofilm with highly active β2,2-amino acid derivatives. 3rd International Symposium on Antimicrobial Peptides, Lille (2012).
Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm. Mechanisms of cancer cell death induced by novel cationic β-peptidomimetics. 22nd American Peptide Symposium, San Diego (2011).
Terkel Hansen, Dominik Ausbacher, Martina Havelkova, Morten B. Strøm. Bactericidal activity of small β-peptidomimetics. 31. European Peptide Symposium, Copenhagen (2010).
Veronika Tørfoss, Dominik Ausbacher, Terkel Hansen, Martina Havelkova, Morten B. Strøm Anticancer activity of small cationic β-peptidomimetics. 31. European Peptide Symposium, Copenhagen (2010).
C. Becker, A. Ehmer, A. Maschke, A. Meindorfer, D. Ausbacher, J. Tessmar, T. Blunk, A. Goepferich. Influence of Micronisation of Proteins on the Properties of Lipid Microparticles for Controlled Release. DPhG Joint Meeting, Marburg (2006).
Publications:
Ausbacher, D.; Svineng, G.; Hansen, T.; Strøm M.B. (2012). Anticancer mechanisms of action of two small amphipathic β2,2-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta (BBA) - Biomembranes 1818: 2917-2925.
Hansen, T.; Ausbacher, D.; Zachariassen, Z.G.; Anderssen, T.; Havelkova, M.; Strøm M.B. (2012) Anticancer activity of small amphipathic β2,2-amino acid derivatives, European Journal of Medicinal Chemistry, 58, 22-29.
Tørfoss, V.; Isaksson, J.; Ausbacher, D.; Brandsdal, B. O.; Flaten, G. E.; Anderssen, T.; Cavalcanti-Jacobsen, C. de A.; Havelkova, M.; Nguyen, L. T.; Vogel, H. J.; Strøm, M. B. (2012) Improved anticancer potency by head-to-tail cyclisation of short cationic anticancer peptides containing a lipophilic β2,2-amino acid, Journal of Peptide Science, 18: 609-619
Tørfoss, V.; Ausbacher, D.; Cavalcanti-Jacobsen, C.deA.; Hansen, T.; Brandsdal, B-.O.; Havelkova, M.; Strøm, M.B. (2011): Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block, Journal of Peptide Science 18: 170-176.
Hansen, T.; Ausbacher, D.; Flaten, G. E.; Havelkova, M.; Strøm, M. B. (2011): Synthesis of cationic antimicrobial β2,2-amino acid derivatives with potential for oral administration, Journal of Medicinal Chemistry 54: 858-868.
Hupfeld, S.; Moen, H. H.; Ausbacher, D.; Haas, H.; Brandl, M. (2010): Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid. Chemistry and Physics of Lipids 163: 141-147.
Hupfeld, S.; Ausbacher, D.; Brandl, M. (2009): Asymmetric flow field-flow fractionation of liposomes: 2. Concentration-detection and adsorptive loss phenomena. Journal of Separation Science 32: 3555-3561.
Hupfeld, S.; Ausbacher, D.; Brandl, M. (2009): Asymmetric flow field-flow fractionation of liposomes: optimization of fractionation variables. Journal of Separation Science 32: 1465-1470.
Studies and Education:
11/2012PhD thesis defence: Biological activity of β2,2-amino acid derivatives derived from antimicrobial peptides- Investigations of Antimicrobial and Anticancer Activity and the Mechanisms of Action
10/2008 - 09/2012Ph.D. student, University of Tromsø, Faculty of Health Sciences, Natural Products and Medicinal Chemistry Research Group Prof. M. B. Strøm 07/2008Licensure for the profession as pharmacist 10/2007Diploma defence, A4F/MALS Analysis of Liposomes University of Halle, Faculty of Biosciences, Department of Pharmaceutical Technology Prof. K. Mäder 05 - 10/2007Diploma student, University of Tromsø, Faculty of Health Sciences, Drug Transport and Delivery Research Group Prof. M. Brandl 04/2007Second State Exam
08/2004First State Exam
10/2002 - 04/2007University of Regensburg, Studies of pharmacy 06/2001Karlsgymnasium Bad Reichenhall, University-entrance diploma
Work experience:
09/2008Researcher for Epitarget AS, Oslo 11/2007 - 04/2008Pharmacist in practical training, Ahorn Apotheke, RegensburgIndustrial Placements:
09/2006 - 10/2006Aenova Sales Pharma - Dragenopharm-Apotheker Püschel GmbH & Co. KG, TittmoningArbeider i CRIStin
- Ausbacher, Dominik; Svineng, Gunbjørg; Hansen, Terkel; Strøm, Morten B.. Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta - Biomembranes 2012; Volum 1818 (11). ISSN 0005-2736.s 2917 - 2925.s doi: 10.1016/j.bbamem.2012.07.005.
- Hansen, Terkel; Ausbacher, Dominik; Zachariassen, Zack Georg; Anderssen, Trude; Havelkova, Martina; Strøm, Morten B.. Anticancer activity of small amphipathic β2,2-amino acid derivatives. European Journal of Medicinal Chemistry 2012; Volum 58. ISSN 0223-5234.s 22 - 29.s doi: 10.1016/j.ejmech.2012.09.048.
- Tørfoss, Veronika; Ausbacher, Dominik; Cavalcanti Jacobsen, Cristiane de Albuquerque; Hansen, Terkel; Brandsdal, Bjørn Olav; Havelkova, Martina; Strøm, Morten B.. Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block. Journal of Peptide Science 2012; Volum 18 (3). ISSN 1075-2617.s 170 - 176.s doi: 10.1002/psc.1434.
- Tørfoss, Veronika; Isaksson, Johan; Ausbacher, Dominik; Brandsdal, Bjørn Olav; Flaten, Gøril Eide; Anderssen, Trude; Cavalcanti Jacobsen, Cristiane de Albuquerque; Havelkova, Martina; Nguyen, Leonard T.; Vogel, Hans J.; Strøm, Morten B.. Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic b2,2-amino acid. Journal of Peptide Science 2012; Volum 18 (10). ISSN 1075-2617.s 609 - 619.s doi: 10.1002/psc.2441.
- Hansen, Terkel; Ausbacher, Dominik; Flaten, Gøril Eide; Havelkova, Martina; Strøm, Morten B.. Synthesis of Cationic Antimicrobial beta(2,2)-Amino Acid Derivatives with Potential for Oral Administration. Journal of Medicinal Chemistry 2011; Volum 54 (3). ISSN 0022-2623.s 858 - 868.s doi: 10.1021/jm101327d.
- Hupfeld, Stefan; Moen, Helene; Ausbacher, Dominik; Haas, Heinrich; Brandl, Martin. Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid. Chemistry and Physics of Lipids 2010; Volum 163 (2). ISSN 0009-3084.s 141 - 147.s doi: 10.1016/j.chemphyslip.2009.10.009.
- Hupfeld, Stefan; Ausbacher, Dominik; Brandl, Martin. Asymmetric flow field-flow fractionation of liposomes: 2. Concentration detection and adsorptive loss phenomena. Journal of Separation Science 2009; Volum 32 (20). ISSN 1615-9314.s 3555 - 3561.s doi: 10.1002/jssc.200900292.
- Hupfeld, Stefan; Ausbacher, Dominik; Brandl, Martin. Asymmetric flow field-flow fractionation of liposomes: optimization of fractionation variables. Journal of Separation Science 2009; Volum 32 (9). ISSN 1615-9314.s 1465 - 1470.s doi: 10.1002/jssc.200800626.
- Ausbacher, Dominik; Kujala, Janni; Vuorela, Pia M.; Strøm, Morten B.; Adyary, Fallarero. Control of Staphylococcus aureus biofilm with highly active β2,2-amino acid derivatives. 3rd International Symposium on Antimicrobial Peptides 2012-06-13 - 2012-06-15 2012.
- Pohjala, Leena; Ausbacher, Dominik; Strøm, Morten B.; Vuorela, Pia M.. Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides. 7th meeting of the European society for Chlamydia research 2012-07-01 - 2012-07-06 2012.
- Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics. Biopolymers 2011; Volum 96 (4). ISSN 0006-3525.s 456 - 457.
- Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics. American Peptide Symposium 2011-06-25 - 2011-06-30 2011.
- Hansen, Terkel; Ausbacher, Dominik; Havelkova, Martina; Strøm, Morten B.. Bactericidal activity of small β-peptidomimetics. European Peptide Symposium 2010-09-05 - 2010-09-09 2010.
