Engelsk personkort
Forskningsinteresser
- Molecular modeling, docking and scoring, Molecular dynamic simulation, combined quantum mechanics-molecular mechanics (QMMM) studies
- Small molecular binding assays and enzyme kinetic studies
- Therapeutic inhibitor design to disease related human enzymes
Arbeider i CRIStin
- Wuxiuer, Yimingjiang; Morgunova, Ekaterina; Cols, Neus; Popov, Alexander; Karshikoff, Andrey; Sylte, Ingebrigt; Gonzàlez-Duarte, Roser; Ladenstein, Rudolf; Winberg, Jan-Olof. An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity. The FEBS Journal 2012; Volum 279 (16). ISSN 1742-464X.s 2940 - 2956.s doi: 10.1111/j.1742-4658.2012.08675.x.
- Khan, Mahmud Tareq Hassan; Wuxiuer, Yimingjiang; Sylte, Ingebrigt. Binding Modes and Pharmacophore Modelling of Thermolysin Inhibitors. Mini-Reviews in medical chemistry 2012; Volum 12 (6). ISSN 1389-5575.s 515 - 533.
- Khan, Mahmud Tareq Hassan; Khan, R.; Wuxiuer, Yimingjiang; Arfan, M.; Ahmed, M.; Sylte, Ingebrigt. Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases. Bioorganic & Medicinal Chemistry 2010; Volum 18 (12). ISSN 0968-0896.s 4317 - 4327.s doi: 10.1016/j.bmc.2010.04.083.
- Khan, Mahmud Tareq Hassan; Wuxiuer, Yimingjiang; Sylte, Ingebrigt. Molecular recognition of thermolysin and homologous zinc-metalloproteinases. Minerva biotecnologica (Testo stampato) 2007; Volum 19. ISSN 1120-4826.s 139 - 150.
- Wuxiuer, Yimingjiang; Cols, N; Gonzalez-Duarte, R; Ladenstein, R; Sylte, Ingebrigt; Winberg, Jan-Olof. Kinetic characterization of the Drosophila lebanonensis ADH T114V mutant. The FEBS Journal 2010; Volum 277. ISSN 1742-464X.s 265 - 265.
