Hensten, Arne

Ansvarlig for gjennomføringen av den kliniske undervisning.
Kontaktperson for rekruttering av vitenskapelig personale.
Koordinerer brukermedvirkningen i klinikkbygget.

Hensten, Arne                                                                                  

Formal name change June 2003 from Arne Hensten-Pettersen to Arne Hensten

 Overall Scientific Expertise

 My main research area is safety evaluation of medical devices used in dentistry. This includes in vitro cell culture studies, animal studies and clinical consultation with patients and professionals who complain of adverse reactions to dental biomaterials. This has resulted in more than 200 publications in international scientific journals.

 Most of my research has been performed at NIOM, Nordic Institute of Dental Materials, which is a resource centre for the Departments of Health of the five Nordic countries (Denmark, Finland, Iceland, Norway, Sweden) in all aspects of the quality, safety and efficacy of dental biomaterials.

 Professional experience

Other professional activities

  Educational background

 Other educational activities

 1975: International Symposium on Chemical Toxicity in Man, University of Surrey,

Guildford, UK

1977: Nordic Council Scientific Training Course in Toxicology, Oslo.

1985: Department of Health and Social Security (Sweden). Training seminar for resource persons for referral of patients with health problems related to dental materials.

1990: Safety evaluation of medical devices, Amsterdam.

1990 Training programs for developing quality assurance systems in laboratories - related to developing intramural quality system according to EN 45001: General criteria for the operation of testing laboratory, for which NIOM was accredited by Norwegian Accreditation in 1992.

1991: CEN-Healthcare Sector Training Seminar: How to write standards, Brussels

1992: Implant Retrieval Symposium, Society for Biomaterials, St. Charles, Illinois

1992: Biological, Material and Mechanical Considerations for Joint Replacement: Current Concepts and Future Direction, Bristol-Myers Squibb/Zimmer Orthopedic Research Symposium, San Antonio, Texas.

1994: Interpreting the Medical Device Directive, Brussels

ISO 9001 Course, Det norske Veritas, Oslo

Activities in Scientific Advisory Bodies/Committees/Panels

 1985:  Biocompatibility, Toxicity and Hypersensitivity to Alloy Systems Used in Dentistry. International Workshop. Ann Arbor, Michigan

1991:   Symposium on Esthetic Restorative Materials, American Dental Association, Chicago.

1991:   Effects and Side Effects of Dental Restorative materials. National Institute of Health (USA): Technology Assessment Conference at National Institute of Dental Research, Bethesda, Maryland.

1995:   Alternatives to the Animal Testing of Medical Devices. ECVAM Workshop 17, Copenhagen. ECVAM ‑ European Centre for the Validation of Alternative Methods.

1995-1997: Delegate from Notified Body Meeting Group as expert in “EEA ad hoc working group on the evaluation of dental amalgam”. A “Draft report” was presented in 1998.

1996:   Dental Filling Materials: Hazards to patients and the environment? Central European Division/Scandinavian Division Symposium, Berlin.

1997:   Expert delegate to World Health Organization (WHO) Consultation on "Dental Amalgam and its Alternatives", Geneva. Developed a revised “WHO consensus statement”.

1997    International Conference on Human Health Effects of Mercury Exposure. Torshavn, Faeroe Islands.

1998:   Invited expert at the Swedish Research Council seminar series: Dental amalgam and health risks

1999:   International Agency for Research on Cancer (IARC, Lyon): Invited as expert and leader of working group for IARC Monograph # 74: Surgical implants and other foreign bodies

2000:   Carious lesions. Management alternatives. Medical University of South Carolina, College of Dental Medicine.

 1990-2004:  Member, Scientific Committee on medicinal products and medical                   devices. European Commission, DG SANCO (Health and Consumer protection)

2007 – 2008: Expert member of working group for SCENIHR’s “Opinion on the safety of dental amalgam and alternative dental restoration materials for patients and users”

2009 -2010: Expert member for the Swedish Board of Health in developing guidelines for dental treatment modalities

2011-   Member, Scientific Committee on Emerging and Newly Identified Health Risks. European Commission, DG SANCO (Health and Consumer protection)

 Membership in professional organisations

 International Association for Dental Research (IADR)

Norwegian Dental Association (NTF)

Norwegian Society for Pharmacology and Toxicology (NSFT)

Scandinavian Society for Immunology (SSI)

Society for Biomaterials (SFB)

 Member of editorial board

 Journal of biomedical materials research

 Activities in international standardisation

 I participate in the standardization activities of CEN/TC 55, Dentistry and CEN/TC 206, Biocompatibility of medical devices, and in the international counterparts: ISO/TC 106 Dentistry and ISO/TC 194: Biological evaluation of medical devices. I am convenor of ISO/TC 194, Working Group 10, which is responsible for developing the standard ”ISO 10993‑6: Biological evaluation of medical devices. Part 6. Tests for local effects after implantation”.

I am convenor of CEN/TC 55/Working Group 4, which, together with ISO/TC 106/WG 10, has developed ISO 7405 (1997): Pre-clinical evaluation of medical devices used in dentistry.

I have been national delegate to the CEN ABHS (Advisory Board for Heathcare Standards) since it started in 2006, and am at present convenor of ABHS Task Force 9: Traceability of medical devices.

 Selected publications

 Kallus T, Hensten-Pettersen A & Mjör IA. Tissue response to allergenic leachables from dental materials. J Biomed Mater Res 1983, 17, 741-55.

 Brune D, Kjærheim Å, Hensten-Pettersen A. & Marion L. Corrosion of dental alloys studied by implantation and nuclear tracer technique. Acta Odontol Scand 1983, 41, 129-34

 Hensten-Pettersen, A., Ørstavik, D. & Wennberg, A. Allergenic potential of endodontic sealers. Endod Dent Traumatol 1985, 1, 61-5

 Syrjänen S, Hensten-Pettersen A. & Nilner K. In vitro testing of dental materials by means of macrophage cultures. II: Effects of particulate dental amalgams and their constituent phases on cultured macrophages. J Biomed Mater Res 1986, 20, 1125-38

 Hensten-Pettersen, A.: Replacement of restorations based on material allergies, In: Quality Evaluation of Dental Restorations. Criteria for Placement and Replacement K.J. Anusavice, ed., Quintessence Publ. Co., Inc. 1989, Chicago, London, Berlin, Sao Paulo, Hong Kong, and Tokyo, pp 357-72.

 Kerosuo H, Kullaa, A, Kerosuo E, Kanerva L, Hensten-Pettersen A: Nickel allergy in adolescents in relation to orthodontic treatment and piercing of ears, Amer J Orthodont Dentofac Orthop, 1996, 109, 148-154

 Schedle A, Örtengren UT, Eidler N, Gabauer M, Hensten A.
Do adverse effects of dental materials exist? What are the consequences, and how can they be diagnosed and treated ? Clinical Oral Implants Research 2007, 18. 232-256.