Institutt for farmasi
Engelsk personkortSeternes, Ole Morten
Professor
Farmasi
Funksjon
Gruppeleder forskingsgruppe i farmakologi
Telefon
776 46506
Epost
Kontor/besøksadresse
Farmasibygget
FARM F2.105
Foto: Bjørn-Kåre Iversen
Forskningsinteresser
Cell signalling and protein kinases regulation with relevance to cancer. Drug discovery for compunds with anti-cancer activities.
Arbeider i CRIStin
- Urbarova, Ilona; Karlsen, Bård Ove; Okkenhaug, Siri; Seternes, Ole Morten; Johansen, Steinar; Emblem, Åse. Digital Marine Bioprospecting: Mining New Neurotoxin Drug Candidates from the Transcriptomes of Cold-Water Sea Anemones. Marine Drugs 2012; Volum 10 (10). ISSN 1660-3397.s 2265 - 2279.s doi: 10.3390/md10102265.
- Larsen, Anett Kristin; Seternes, ole morten; Larsen, Merethe; Kishimura, Hideki; Rudenskaya, Galina N; Bang, Berit. Purified sardine and king crab trypsin display individual differences in PAR-2-, NF-kB-, and IL-8 signaling. Toxicological & Environmental Chemistry 2011; Volum 93 (10). ISSN 0277-2248.s 1991 - 2011.s doi: 10.1080/02772248.2011.614380.
- Seternes, ole morten; Johansen, Bjarne Herold; Hegge, Beate; Johannessen, Mona; Keyse, Stephen M; Moens, Ugo. Both Binding and Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Play Essential Roles in Regulation of the Nucleocytoplasmic Distribution of MAPK-Activated Protein Kinase 5 by Cellular Stress. Molecular and Cellular Biology 2010; Volum 22 (20). ISSN 0270-7306.s 6931 - 6945.s doi: 10.1128/MCB.22.20.6931-6945.202.
- Johansen, Steinar D.; Emblem, Åse; Karlsen, Bård Ove; Okkenhaug, Siri; Hansen, Hilde; Moum, Truls; Coucheron, Dag-Hugo; Seternes, ole morten. Approaching marine bioprospecting in hexacorals by RNA deep sequencing. New Biotechnology 2010; Volum 27 (3). ISSN 1871-6784.s 267 - 275.s doi: 10.1016/j.nbt.2010.02.019.
- Åberg, espen; Torgersen, Knut Martin; Johansen, Bjarne Herold; Keyse, Stephen M; Perander, maria; Seternes, ole morten. Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif. Journal of Biological Chemistry 2009; Volum 284 (29). ISSN 0021-9258.s 19392 - 19401.s doi: 10.1074/jbc.M109.023283.
- Perander, maria; Åberg, espen; Johansen, Bjarne Herold; Dreyer, Bo; Guldvik, Ingrid Jenny; Outzen, heidi; Keyse, Stephen M; Seternes, ole morten. The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5. Biochemical Journal 2008; Volum 411. ISSN 0264-6021.s 613 - 622.s doi: 10.1042/BJ20071369.
- Perander, maria; Keyse, Stephen M; Seternes, ole morten. Does MK5 reconcile classical and atypical MAP kinases?. Frontiers in Bioscience 2008; Volum 13. ISSN 1093-9946.s 4617 - 4624.
- Larsen, Anett Kristin; Seternes, ole morten; Larsen, Merethe; Aasmoe, lisbeth; Bang, Berit. Salmon trypsin stimulates the expression of interleukin-8 via protease-activated receptor-2. Toxicology and Applied Pharmacology 2008; Volum 230. ISSN 0041-008X.s 276 - 282.s doi: 10.1016/j.taap.2008.02.019.
- Hansen, Tom Egil; Puntervoll, Pål; Borgland, A.W.; Seternes, ole morten; Eigen, Gerald; Jørgensen, Jorunn B; Frodesen, A.G.; Keranen, R.; Stugu, Bjarne; et al., DELPHI Collaboration. Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress. The FEBS Journal 2008; Volum 275. ISSN 1742-464X.s 4887 - 4902.s doi: 10.1111/j.1742-4658.2008.06628.x.
- Michaelsen, espen; Perander, maria; Johansen, Bjarne Herold; Julien, Catherine; Meloche, Sylvain; Keyse, Stephen M; Seternes, ole morten. Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4. Journal of Biological Chemistry 2006; Volum 281 (46). ISSN 0021-9258.s 35499 - 35510.
- Johannessen, Mona; Delghandi, Marit Pedersen; Seternes, Ole Morten; Johansen, Bjarne; Moens, Ugo Lionel. Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain. Cellular Signalling 2004; Volum 16 (10). ISSN 0898-6568.s 1187 - 1199.
- Seternes, Ole Morten; Mikalsen, Theresa; Johansen, Bjarne; Michaelsen, Espen; Armstrong, CG; Morrice, NA; Turgeon, B; Meloche, S; Moens, Ugo Lionel; Keyse, SM. Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. EMBO Journal 2004; Volum 23 (24). ISSN 0261-4189.s 4780 - 4791.s doi: 10.1038/sj.emboj.7600489.
- Hendrickx, Nico; Volanti, Cédric; Moens, Ugo; Seternes, ole morten; De Witte, Peter; Vandenheede, Jackie R. Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. Journal of Biological Chemistry 2004; Volum 278. ISSN 0021-9258.s 52231 - 52239.
- Hendrickx, Nico; Volanti, Cédric; Moens, Ugo Lionel; Seternes, Ole Morten; De Witte, Peter; Vandenheede, Jackie R; Piette, Jacques; Agostini, Patrizia. Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. Journal of Biological Chemistry 2003; Volum 278 (52). ISSN 0021-9258.s 52231 - 52239.s doi: 10.1074/jbc.M307591200.
- Johannessen, Mona; Olsen, Petter Angell; Sørensen, Rita Irene; Johansen, Bjarne; Seternes, Ole Morten; Moens, Ugo Lionel. A role of the TATA box and the general co-activator hTAFII130/135 in promoter-specific trans-activation by simian virus 40 small t antigen. Journal of General Virology 2003; Volum 84. ISSN 0022-1317.s 1887 - 1897.s doi: 10.1099/vir.0.19057-0.
- Johannessen, Mona; Olsen, Petter Angell; Johansen, Bjarne; Seternes, Ole Morten; Moens, Ugo Lionel. Activation of the coactivator foru-and-a-half-LIM-only protein FHL2 and the c-fos promoter through inhibition of protein phosphatase 2A. Biochemical Pharmacology 2003; Volum 65. ISSN 0006-2952.s 1317 - 1328.
- Kristoffersen, Anne Karin; Johnsen, Jon Inge; Seternes, Ole Morten; Rollag, Halvor; Degre, Miklos; Traavik, Terje. The human polyomavirus BK T antigen induces gene expression in human xcytomegalovirus. Virus Research 1997; Volum 52. ISSN 0168-1702.s 61 - 71.
- Perander, maria; Stiberg, Trine; Myhren, Lene Elisabeth; Hansen, Espen; Seternes, ole morten; Herfindal, Lars; Andersen, Jeanette hammer; Jørgensen, Trond Ø.. Characterization of cytotoxic activities in extracts from two marine invertebrates. Bioprosp 2011 2011-02-23 - 2011-02-25 2011.
- Johansen, Steinar Daae; Andreassen, morten; Babiak, Igor; Bizuayehu, Teshome; Coucheron, Dag-Hugo; El-Gewely, M. Raafat; Emblem, Åse; Fiskaa, Tonje; Furmanek, Tomasz; Haugli, kari b.; Karlsen, Bård Ove; Klingan, Kevin; Knutsen, Erik; Jørgensen, Tor Erik; Moum, Truls Borg; Nordeide, Jarle Tryti; Okkenhaug, Siri; Rekvig, Ole Petter; Seternes, ole morten; Ursvik, anita. Investigating miRNAs and transcriptomes at our local SOLiD sequencing facility. The Norwegian Biochemical Society 47th Contact Meeting 2011-02-03 - 2011-02-06 2011.
- Larsen, Merethe; Bang, Berit; Seternes, ole morten; Larsen, Anett K.. Protease-activated signal pathways in airway cells. Purified salmon trypsin activates nuclear factor kappa-B and induces interleukin-8 secretion in human airway epithelial cells (A549). Allergy. European Journal of Allergy and Clinical Immunology 2007; Volum 62. ISSN 0105-4538.
- Åberg, Espen; Perander, maria; Johansen, Bjarne Herold; Julien, Catherine; Meloche, Sylvain; Keyse, Stephen M; Seternes, ole morten. Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAP kinase ERK4/MAPK4. 15th Protein Kinase Meeting 2006-09-21 - 2006-09-24 2006.
- Seternes, ole morten. The atypical MAP kinases ERK3 and 4 defines novel signaling pathways. Seminar 2006-11-10 - 2006.
- Seternes, ole morten. The atypical MAP kinases ERK3 and 4 defines novel signaling pathways. Instituttseminar 2006-11-07 - 2006.
