Lamark, Trond

Autofagi
Cellesignalering

Svenning, S., Lamark, T., Krause, K., and Johansen, T:
Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1.
Autophagy. 2011, 7: 993-1010.

Johansen, T and Lamark, T:
Selective autophagy mediated by autophagic adapter proteins.
Autophagy. 2011, 7: 279-296.

Nezis, IP., Shravage, BV., Sagona, AP., Lamark, T., Bjørkøy, G., Johansen, T., Rusten, TE., Brech, A., Baehrecke, EH., and Stenmark, H:
Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila oogenesis.
J Cell Biol. 2010, 190: 523-31.

Larsen, KB., Lamark, T., Øvervatn, A., Harneshaug, I., Johansen, T., Bjørkøy, G:
A novel reporter cell system to estimate the speed of autophagy.
Autophagy. 2010, 16: 784-93.

Jain, A., Lamark, T., Sjøttem, E., Larsen, KB., Awuh, JA., Øvervatn, A., McMahon, M., Hayes, JD., Johansen, T:
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response-driven gene transcription.
J Biol Chem. 2010, 285:22576-91.

Filimonenko, M., Isakson, P., Sanderson, M., Finley, K., Jeong, H., Melia, T., Bartlett, BJ., Birkeland, HCG., Lamark, T., Brech, A, Stenmark, H., Krainc, D., Simonsen, A., and Yamamoto, A:
The selective macroautophagic degradation of aggregated proteins requires the
phosphatidylinositol 3-phosphate binding protein Alfy.
Molecular Cell. 2010, 38:265-79.

Clausen, TH., Lamark, T., Isakson, P., Finley, K., Larsen, KB., Brech, A., Øvervatn, A., Stenmark, H., Bjørkøy, G., Simonsen, A., and Johansen, T:
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.
Autophagy. 2010, 6:330-44.

Pankiv, S., Lamark, T., Bruun, JA., Øvervatn, A., Bjørkøy, G., and Johansen, T:
Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to PML bodies.
J Biol Chem. 2010, 285:5941-53.

Pankiv, S., Alemu, EA., Brech, A., Bruun, JA., Lamark, T., Øvervatn, A., Bjørkøy, G., and Johansen, T:
FYCO1 is a novel Rab7 effector binding to LC3 and PI3P to mediate microtubule plus-end-directed vesicle transport.
J Cell Biol. 2010, 25:253-69.

Lamark, T., and Johansen, T:
Autophagy – links with the proteasome.
Curr Opin Cell Biol. 2010, 22:192-8.

Zheng, YT., Shahnazari, S., Brech, A., Lamark, T., Johansen, T., and Brumell, JH:
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway.
J Immunol. 2009, 183:5909-16.

Lamark, T., Kirkin, V., Dikic, I., and Johansen, T:
NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets.
Cell Cycle. 2009, 8:1986-90.

Kirkin, V., Lamark, T., Johansen, T., and Dikic, I:
NBR1 co-operates with p62 in selective autophagy of ubiquitinated targets.
Autophagy. 2009, 5:732-33.

Kirkin, V., Lamark, T., Sou, Y-S., Bjørkøy, G., Nunn, JL., Bruun, JA., Shvets, E., McEwan, DG., Clausen, TH., Bilusic, I., Theurillat, J-P., Øvervatn, A., Ishii, T., Elazar, Z., Komatsu, M., Dikic, I., and Johansen, T:
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Molecular Cell. 2009, 33:505-16.

Bjørkøy, G., Lamark, T., Pankiv, S., Øvervatn, A., Brech, A., and Johansen, T:
Monitoring autophagic degradation of p62/SQSTM1.
Meth Enzymol. 2009, 452:181-97.

Nezis, N. P., Lamark, T., Velentzas, AD., Rusten, TE., Bjørkøy, G., Johansen, T., Papassideri, IS., Stravopodis, DJ., Margaritis, LH., Stenmark, H., and Brech, A:
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy.
Autophagy. 2009, 5:298-302.

Pankiv, S., Clausen, TH., Lamark, T., Brech, A., Bruun, JA., Outzen, H., Øvervatn, A., Bjørkøy, G., and Johansen, T:
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
J Biol Chem. 2007, 282:24131-45.

Bjørkøy, G., Lamark, T., and Johansen, T:
p62/SQSTM1: A Missing Link between Protein Aggregates and the Autophagy Machinery.
Autophagy. 2006, 2:138-39.

Erdogan, E., Lamark, T., Stallings-Mann, M., Lee, J., Pellechia, M., Johansen, T., and Fields, AP:
Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota.
J Biol Chem. 2006, 281:28450-59.

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., and Johansen, T:
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.
J Cell Biol. 2005, 171:603-14.

Gruber, FX, Lamark, T., Anonli, A., Sovershaev, MA., Olsen, M., Gedde-Dahl, T., Hjort-Hansen, H., and Skogen, B:
Selecting and deselecting imatinib-resistant clones: observations made by longitudinal, quantitative monitoring of mutated BCR-ABL.
Leukemia. 2005, 19:2159-65.

Lamark, T., Perander, M., Outzen, H., Kristiansen, K., Overvatn, A., Michaelsen, E., Bjørkøy, G., and Johansen, T:
Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.
J Biol Chem. 2003, 278:34568-81.

Lamark. T., Ingebrigtsen, M., Bjørnstad, C., Melkko, T., Mollnes, TE., and Nielsen, EW:
Expression of active human C1 inhibitor serpin domain in Escherichia coli.
Protein Expr Purif. 2001, 22:349-58.

Lamark. T., Røkenes, TP., McDougall, J., and Strøm, AR:
The complex bet promoters of Escherichia coli: Regulation by oxygen (ArcA), choline (BetI) and osmotic stress.
Journal of Bacteriology. 1996, 178: 1655-62.

Røkenes, TP., Lamark. T., and Strøm, AR:
DNA binding properties of the BetI repressor protein of Escherichia coli: The inducer choline stimulates BetI-DNA complex formation.
Journal of Bacteriology. 1996, 178: 1663-70.

Holmstrøm, K-O., Welin, B., Mandal, A., Kristiansdottir, I., Teeri, TH., Lamark, T., Strøm, AR., and Palva, ET:
Production of the Escherichia coli betaine-aldehyde dehydrogenase, an enzyme required for the synthesis of the osmoprotectant glycine betaine, in transgenic plants.
The Plant Journal. 1994, 6: 749-58.

Lamark. T., Styrvold, OB., and Strøm, AR:
Efflux of choline and glycine betaine from osmoregulating cells of Escherichia coli.
FEMS Microbiological Letters. 1992, 96: 149-54.

Lamark. T., Kaasen, I., Eshoo, MW., Falkenberg, P., McDougall, J., and Strøm, AR:
DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli.
Molecular Microbiology. 1991, 5:1049-64.

Utdanning
Dr. scient. i Marin biokjemi ved Norges Fiskerihøgskole, UiTø (november 1995)

Yrkespraksis
1.10.1995-30.4.1998: Post. Doc. ved Norges Fiskerihøgskole, UiTø
1.6.1998-31.12.2001: Vikariat som førsteamanuensis ved IFA, UiTø
1.1.2002-31-12.2010: Forsker ved IMB, UiTø
Fra 1.1.2011: Førsteamanuensis ved Molekylær Kreftforskningsgruppe, IMB, UiTø