Engelsk personkortSylte, Ingebrigt
Professor
Medisinsk biologi
Funksjon
Professor
Telefon
776 44705
Epost
Kontor/besøksadresse
Medisin og Helsefag
MH L8.131
Forskningsprosjekter
Gruppen bruker molekylmodellering og strukturell bioinformatikk til å studere struktur, molekylære-mekanismer og -interaksjoner av proteiner som er mål for legemidler (“drug targets”). Sekvens- og struktur-analyser og homologi basert modellering blir brukt til å konstruere tredimensjonale modeller. Automatisk dokking og molekylær dynamikksimuleringer blir brukt til prediksjon av bindingsstyrke og studere konformasjonelle forandringer som følge av kompleksdannelsen mellom proteiner og andre molekyler (proteiner og lavmolekylære forbindelser). Virtuell ligand screening blir brukt til å lete etter nye molekyler som kan påvirke “drug targets”.
Følgende “drug targets” blir studert:
- Nevrotransmitter membran-transportproteiner (SERT, DAT, NET).
- Serotonerge-, dopaminerge- og glutaminerge - G-protein koblede reseptorer.
- ABC transportproteiner.
- Nukleære reseptorer.
- Thermolysin like zinc metalloproteinaser (thermolysin, pseudolysin, matrix metalloproteinases).
- Kortkjedede alkohol dehydrogenaser.
- Protein kinasen - MK5.
Arbeider i CRIStin
- Baglo, Yan; Gabrielsen, Mari; Sylte, Ingebrigt; Gederaas, Odrun Arna. Homology Modeling of Human <gamma>-Butyric Acid Transporters and the Binding of Pro-drugs 5-Aminolevulinic Acid and Methyl Aminolevulinic Acid used in Photodynamic Therapy. PLoS ONE 2013. ISSN 1932-6203.s doi: 10.1371/journal.pone.0065200.
- Wuxiuer, Yimingjiang; Morgunova, Ekaterina; Cols, Neus; Popov, Alexander; Karshikoff, Andrey; Sylte, Ingebrigt; Gonzàlez-Duarte, Roser; Ladenstein, Rudolf; Winberg, Jan-Olof. An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity. The FEBS Journal 2012; Volum 279 (16). ISSN 1742-464X.s 2940 - 2956.s doi: 10.1111/j.1742-4658.2012.08675.x.
- Khan, Mahmud Tareq Hassan; Wuxiuer, Yimingjiang; Sylte, Ingebrigt. Binding Modes and Pharmacophore Modelling of Thermolysin Inhibitors. Mini-Reviews in medical chemistry 2012; Volum 12 (6). ISSN 1389-5575.s 515 - 533.
- Sylte, Ingebrigt; Ravna, aina westrheim. Homology Modeling of Transporter Proteins (Carriers and Ion Channels). Humana Press 2012 (857). ISSN 1064-3745.s 281 - 299.
- Fadnes, Bodil Irene; Hadler-Olsen, Elin Synnøve; Sylte, Ingebrigt; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Matrix metalloproteinase complexes and their biological significance. Walter de Gruyter 2012 ISBN 978-3-11-025876-9.s 291 - 314.
- Gabrielsen, Mari; Kurczab, Rafal; Ravna, aina westrheim; Kufareva, Irina; Abagyan, Ruben; Chilmonczyk, Zdzislaw; Bojarski, Andrezej J; Sylte, Ingebrigt. Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol. European Journal of Medicinal Chemistry 2012; Volum 47. ISSN 0223-5234.s 24 - 37.s doi: 10.1016/j.ejmech.2011.09.056.
- Khan, Mahmud Tareq Hassan; Dedachi, Kenichi; Matsui, Toshiro; Kurita, Noriyuki; Borgatti, Monica; Gambari, Roberto; Sylte, Ingebrigt. Dipeptide Inhibitors of Thermolysin and Angiotensin I-Converting Enzyme. Current Topics in Medicinal Chemistry 2012; Volum 12 (16). ISSN 1568-0266.s 1748 - 1762.
- Hessvik, Nina Pettersen; Bakke, Siril Skaret; Smith, Robert; Ravna, aina westrheim; Sylte, Ingebrigt; Rustan, Arild; Thoresen, G. Hege; Kase, Eili Tranheim. The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. Journal of Steroid Biochemistry and Molecular Biology 2012; Volum 128. ISSN 0960-0760.s 154 - 164.s doi: 10.1016/j.jsbmb.2011.10.006.
- Gabrielsen, Mari; Ravna, aina westrheim; Kristiansen, kurt; Sylte, Ingebrigt. Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations.. Journal of Molecular Modeling 2012; Volum 18 (3). ISSN 0948-5023.s 1073 - 1085.s doi: 10.1007/s00894-011-1133-1.
- Witowska-Jarosz, Janina; Jaronczyk, Malgorzata; Mazurek, Aleksander P; Sylte, Ingebrigt; Bojarski, Andrezej J; Chilmonczyk, Zdzislaw; Jarosz, Maciej. Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors. Analytical and Bioanalytical Chemistry 2012; Volum 402 (1). ISSN 1618-2642.s 537 - 541.s doi: 10.1007/s00216-011-5410-8.
- Hirakawa, Tatsuya; Fujita, Seiya; Ohyama, Tatsuya; Dedachi, Kenichi; Khan, Mahmud Tareq Hassan; Sylte, Ingebrigt; Kurita, Noriyuki. Specific interactions and binding energies between thermolysin and potent inhibitors: Molecular simulations based on ab initio molecular orbital method. Journal of Molecular Graphics and Modelling 2012; Volum 33. ISSN 1093-3263.s 1 - 11.s doi: 10.1016/j.jmgm.2011.10.006.
- Jaronczyk, Malgorzata; Wolosewicz, Karol; Gabrielsen, Mari; Nowak, Gabriel; Kufareva, Irina; Mazurek, Aleksander P; Ravna, aina westrheim; Abagyan, Ruben; Bojarski, Andrezej J; Sylte, Ingebrigt; Chilmonczyk, Zdzislaw. Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors. European Journal of Medicinal Chemistry 2012; Volum 49. ISSN 0223-5234.s 200 - 210.s doi: 10.1016/j.ejmech.2012.01.012.
- Sylte, Ingebrigt; Ravna, aina westrheim; Dahl, Svein G.. Templates and models of monoamine transporter proteins. Current Medicinal Chemistry 2011; Volum 18 (30). ISSN 0929-8673.s 4651 - 4658.
- Dedachi, Kenichi; Hirakawa, Tatsuya; Fujita, Seiya; Khan, Mahmud Tareq Hassan; Sylte, Ingebrigt; Kurita, Noriyuki. Specific Interactions and Binding Free Energies Between Thermolysin and Dipeptides: Molecular Simulations Combined with Ab Initio Molecular Orbital and Classical Vibrational Analysis. Journal of Computational Chemistry 2011; Volum 32 (14). ISSN 0192-8651.s 3047 - 3057.s doi: 10.1002/jcc.21887.
- Mordalski, Stefan; Kosciolek, Tomasz; Kristiansen, kurt; Sylte, Ingebrigt; Bojarski, Andrezej J. Protein binding site analysis by means of structural interaction fingerprint patterns. Bioorganic & Medicinal Chemistry Letters 2011; Volum 21 (22). ISSN 0960-894X.s 6816 - 6819.s doi: 10.1016/j.bmcl.2011.09.027.
- Kostenko, Sergiy Viktorovich; Khan, Mahmud Tareq Hassan; Sylte, Ingebrigt; Moens, Ugo. The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor. Cellular and Molecular Life Sciences 2011; Volum 68 (2). ISSN 1420-682X.s 289 - 301.s doi: 10.1007/s00018-010-0452-1.
- Ciocoiu, Calin C.; Ravna, aina westrheim; Sylte, Ingebrigt; Rustan, Arild; Hansen, Trond Vidar. Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516. Bioorganic & Medicinal Chemistry 2011; Volum 19. ISSN 0968-0896.s 6982 - 6988.s doi: 10.1016/j.bmc.2011.10.020.
- Hadler-Olsen, Elin Synnøve; Fadnes, Bodil Irene; Sylte, Ingebrigt; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Regulation of matrix metalloproteinase activity in health and disease. The FEBS Journal 2011; Volum 278 (1). ISSN 1742-464X.s 28 - 45.s doi: 10.1111/j.1742-4658.2010.07920.x.
- Kostenko, Sergiy Viktorovich; Khan, Mahmud Tareq Hassan; Moens, Ugo; Sylte, Ingebrigt. The diterpenoid alkaloid Noroxoaconitine is a MAPKAP Kinase 5 (MK5/PRAK) inhibitor. Cellular and Molecular Life Sciences 2010. ISSN 1420-682X.s doi: 10.1007/s00018-010-0452-1.
- Kurczab, Rafal; Nowak, Mateusz; Chilmonczyk, Zdzislaw; Sylte, Ingebrigt; Bojarski, Andrezej J. The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT7R antagonists. Bioorganic & Medicinal Chemistry Letters 2010; Volum 20 (8). ISSN 0960-894X.s 2465 - 2468.s doi: 10.1016/j.bmcl.2010.03.012.
- Odlo, Kristin; Fournier-Dit-Chabert, Jérémie; Ducki, Sylvie; Gani, Osman A.B.S.M.; Sylte, Ingebrigt; Hansen, Trond Vidar. 1,2,3-Triazole analogs of combretastatin A-4 as potential microtubule-binding agents. Bioorganic & Medicinal Chemistry 2010; Volum 18 (18). ISSN 0968-0896.s 6874 - 6885.s doi: 10.1016/j.bmc.2010.07.032.
- Khan, Mahmud Tareq Hassan; Khan, R.; Wuxiuer, Yimingjiang; Arfan, M.; Ahmed, M.; Sylte, Ingebrigt. Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases. Bioorganic & Medicinal Chemistry 2010; Volum 18 (12). ISSN 0968-0896.s 4317 - 4327.s doi: 10.1016/j.bmc.2010.04.083.
- Ciocoiu, Calin Constantin; Ravna, aina westrheim; Sylte, Ingebrigt; Hansen, Trond Vidar. Synthesis, Biological Evaluation and Molecular Modeling of GW 501516 Analogues. Archiv der Pharmazie 2010; Volum 343 (11-12). ISSN 0365-6233.s 612 - 624.s doi: 10.1002/ardp.201000189.
- Khan, Mahmud T. H.; Sylte, Ingebrigt. Multivariate Linear Regression Models Based on ADME Descriptors and Predictions of ADMET Profile for Structurally Diverse Thermolysin Inhibitors. Letters in Drug Design & Discovery 2009; Volum 6 (6). ISSN 1570-1808.s 428 - 436.
- Herold, Franciszek; Izbicki, Lukasz; Chodkowski, Andrzej; Dawidowski, Maciej; Król, Marek; Kleps, Jerzy; Turlo, Jadwiga; Wolska, Irena; Nowak, Gabriel; Stachowicz, Katarzyna; Dybala, Malgorzata; Siwek, Agata; Nowak, Mateusz; Pieniazek, Elzbieta; Jaronczyk, Malgorzata; Sylte, Ingebrigt; Mazurek, Aleksander P. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: Part 2. European Journal of Medicinal Chemistry 2009; Volum 44. ISSN 0223-5234.s 4702 - 4715.s doi: 10.1016/j.ejmech.2009.07.007.
- Dedachi, Kenichi; Khan, Mahmud T. H.; Sylte, Ingebrigt; Kurita, Noriyuki. A combined simulation with ab initio MO and classical vibrational analysis on the specific interactions between thermolysin and dipeptide ligands. Chemical Physics Letters 2009; Volum 479 (4-6). ISSN 0009-2614.s 290 - 295.s doi: 10.1016/j.cplett.2009.08.036.
- Adekoya, Olayiwola; Sylte, Ingebrigt. The Thermolysin Family (M4) of Enzymes: Therapeutic and Biotechnological Potential. Chemical Biology and Drug Design 2009; Volum 73 (1). ISSN 1747-0277.s 7 - 16.s doi: 10.1111/j.1747-0285.2008.00757.x.
- Khan, Mahmud Tareq Hassan; Fuskevaag, OM; Sylte, Ingebrigt. Discovery of Potent Thermolysin Inhibitors Using Structure Based Virtual Screening and Binding Assays. Journal of Medicinal Chemistry 2009; Volum 52 (1). ISSN 0022-2623.s 48 - 61.s doi: 10.1021/jm8008019.
- Khan, Mahmud T. H.; Sylte, Ingebrigt. Structural Bioinformatics in the Discovery of Novel Drugs. Springer Science+Business Media B.V. 2009 ISBN 978-1-4020-6954-3.s 29 - 38.
- Ravna, aina westrheim; Sager, Georg; Dahl, Svein G.; Sylte, Ingebrigt. Membrane transporters: Structure, function and targets for drug design. Springer Publishing Company 2009 (4) ISBN 978-3-540-87911-4. ISSN 1862-2461.s 15 - 51.
- Gani, Osman A.B.S.M.; Sylte, Ingebrigt. Molecular recognition of long chain fatty acids by peroxisome proliferator-activated receptor alpha. Medicinal Chemistry Research 2009; Volum 18 (1). ISSN 1054-2523.s 8 - 19.s doi: 10.1007/s00044-008-9102-7.
- Ravna, aina westrheim; Sylte, Ingebrigt; Dahl, Svein G.. Structure and localisation of drug binding sites on neurotransmitter transporters. Journal of Molecular Modeling 2009; Volum 15 (10). ISSN 0948-5023.s 1155 - 1164.s doi: 10.1007/s00894-009-0478-1.
- Khan, Mahmud T. H.; Sylte, Ingebrigt. Determinants for Psychrophilic and Thermophilic Features of Metallopeptidases of the M4 Family. In Silico Biology 2009; Volum 9. ISSN 1386-6338.s 105 - 124.s doi: 10.3233/ISB-2009-0392.
- Ravna, aina westrheim; Sylte, Ingebrigt; Sager, Georg. Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure. Theoretical Biology Medical Modelling 2009; Volum 6 (20). ISSN 1742-4682.s doi: 10.1186/1742-4682-6-20.
- Gani, Osman A.B.S.M.; Sylte, Ingebrigt. Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha. Journal of Molecular Graphics and Modelling 2008; Volum 27. ISSN 1093-3263.s 217 - 224.s doi: 10.1016/j.jmgm.2008.04.008.
- Kvernmo, Trond; Houben, John; Sylte, Ingebrigt. Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Current Topics in Medicinal Chemistry 2008; Volum 8 (12). ISSN 1568-0266.s 1049 - 1067.
- Jaronczyk, Malgorzata; Chilmonczyk, Zdizlav; Mazurek, AP; Nowak, Gabriel; Ravna, aina westrheim; Kristiansen, kurt; Sylte, Ingebrigt. The molecular interactions of buspirone analogues with the serotonin transporter. Bioorganic & Medicinal Chemistry 2008; Volum 16 (20). ISSN 0968-0896.s 9283 - 9294.s doi: 10.1016/j.bmc.2008.09.005.
- Ravna, aina westrheim; Sylte, Ingebrigt; Sager, Georg. A molecular model of a putative substrate releasing conformation of multidrug resistance protein 5 (MRP5). European Journal of Medicinal Chemistry 2008; Volum 43 (11). ISSN 0223-5234.s 2557 - 2567.s doi: 10.1016/j.ejmech.2008.01.015.
- Dahl, Svein G.; Sylte, Ingebrigt. Molecular Structure and Dynamics of Drug Targets. Prague Medical Report 2008; Volum 109 (2-3). ISSN 1214-6994.s 107 - 112.
- Gani, Osman A.B.S.M.; Sylte, Ingebrigt. Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma. Chemical Biology and Drug Design 2008; Volum 72. ISSN 1747-0277.s 50 - 57.s doi: 10.1111/j.1747-0285.2008.00677.x.
- Gani, Osman A.B.S.M.; Adekoya, Olayiwola; Giurato, L; Spyrakis, F; Cozzini, P; Guccione, S; Winberg, Jan-Olof; Sylte, Ingebrigt. Theoretical calculations of the catalytic triad in short-chain alcohol dehydrogenases/reductases. Biophysical Journal 2008; Volum 94. ISSN 0006-3495.s doi: 10.1529/biophysj.107.111096.
- Odlo, K; Hentzen, J; dit Chabert, JF; Ducki, S; Gani, Osman A.B.S.M.; Sylte, Ingebrigt; Skrede, M; Flørenes, Vivi Ann; Florenes, VA; Hansen, TV. 1,5-disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin. Bioorganic & Medicinal Chemistry 2008; Volum 16. ISSN 0968-0896.s 4829 - 4838.s doi: 10.1016/j.bmc.2008.03.049.
- Khan, Mahmud Tareq Hassan; Wuxiuer, Yimingjiang; Sylte, Ingebrigt. Molecular recognition of thermolysin and homologous zinc-metalloproteinases. Minerva biotecnologica (Testo stampato) 2007; Volum 19. ISSN 1120-4826.s 139 - 150.
- Khan, Mahmud Tareq Hassan; Sylte, Ingebrigt. Predictive QSAR modeling for the sucessful predictions of the ADMET properties of candidate drug molecules. Current Drug Discovery Technologies 2007; Volum 4. ISSN 1570-1638.s 141 - 149.
- Ravna, aina westrheim; Sylte, Ingebrigt; Sager, Georg. Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5). Theoretical Biology Medical Modelling 2007; Volum 4. ISSN 1742-4682.s 33 - .
- Ravna, Aina Westrheim; Sylte, Ingebrigt; Kristiansen, Kurt; Dahl, Svein G.. Putative drug binding conformations of monoamine transporters. Bioorganic & Medicinal Chemistry 2006; Volum 14. ISSN 0968-0896.
- Adekoya, Olayiwola; Helland, Ronny; Willassen, Nils P; Sylte, Ingebrigt. Comparative sequence and structure analysis reveal features of cold adaptation of an enzyme in the thermolysin family. Proteins: Structure, Function, and Genetics 2006; Volum 62. ISSN 0887-3585.
- Adekoya, Olayiwola; Willassen, Nils Peder; Sylte, Ingebrigt. Molecular insight into pseudolysin inhibition using the MM-PBSA and LIE methods. Journal of Structural Biology 2006; Volum 153. ISSN 1047-8477.s 129 - 144.
- Dahl, Svein G.; Sylte, Ingebrigt. From genomics to drug targets. Journal of Psychopharmacology 2006; Volum 20 (4). ISSN 0269-8811.s 95 - 99.
- Ravna, Aina Westrheim; Jaronczyk, Malgorzata; Sylte, Ingebrigt. A homology model of SERT based on the LeuT(Aa) template. Bioorganic & Medicinal Chemistry Letters 2006; Volum 16. ISSN 0960-894X.s 5594 - 5597.
- Våbenø, Jon; Nielsen, Carsten Uhd; Steffansen, Bente; Lejon, Tore Sigvard; Sylte, Ingebrigt; Jørgensen, Flemming Steen; Luthman, Kristina. Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs. Bioorganic & Medicinal Chemistry 2005; Volum 13. ISSN 0968-0896.s 1977 - 1988.
- Adekoya, Olayiwola Adedotun; Willassen, Nils Peder; Sylte, Ingebrigt. The protein-protein interactions between SMPI and thermolysin studied by molecular dynamics and MM/PBSA calculations. Journal of Biomolecular Structure and Dynamics 2005; Volum 22 (5). ISSN 0739-1102.s 521 - 532.
- Lindstad, Rune I.; Sylte, Ingebrigt; Mikalsen, Svein O.; Seglen, Per O.; Berg, Eli; Winberg, Jan O.. Pancreatic trypsin activates human promatrix metalloproteinase-2. Journal of Molecular Biology 2005; Volum 350. ISSN 0022-2836.s 682 - 698.
- Hjerde, Erik; Dahl, Svein G.; Sylte, Ingebrigt. Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor. European Journal of Medicinal Chemistry 2005; Volum 40. ISSN 0223-5234.
- Lindstad, Rune I; Sylte, Ingebrigt; Mikalsen, S O; Seglen, P O; Berg, Eli; Winberg, Jan-Olof. Pancreatic trypsin activates human promatrix metal loproteinase-2. Journal of Molecular Biology 2005; Volum 350. ISSN 0022-2836.s 682 - 698.
- Dahl, Svein Gunvald; Sylte, Ingebrigt. Molecular modelling of drug targets: The past, the present and the future. Basic & Clinical Pharmacology & Toxicology 2005; Volum 96. ISSN 1742-7835.s 151 - 155.
- Dahl, Svein G.; Sylte, Ingebrigt; Ravna, Aina Westrheim. Structures and models of transporter proteins. Journal of Pharmacology and Experimental Therapeutics 2004; Volum 309 (3). ISSN 0022-3565.s 853 - 860.
- Strzelczyk, Anna Agnieszka; Jaronczyk, Malgorzata; Chilmonczyk, Zdizlav; Mazurek, Pavel A; Chojnacka-Wojcik, Eva; Sylte, Ingebrigt. Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT1A receptors. Biochemical Pharmacology 2004; Volum 67. ISSN 0006-2952.s 2219 - 2230.
- Yang, Nannan; Mekonnen, Seble Merid; Solstad, Terese; Wikman, Mari; Kalaaji, manar; Sylte, Ingebrigt; Rekdal, Øystein. Enhanced tumor cell specificity by optimizing the relative position between aromatic and cationic residues in helical amphipathic peptides.. 2003 ISBN 82-497-0155-0.
- Ravna, Aina Westrheim; Sylte, Ingebrigt; Dahl, Svein G.. Molecular mechanisms of citalopram and cocaine interactions with the neurotransmitter transporter. Journal of Pharmacology and Experimental Therapeutics 2003; Volum 307 (1). ISSN 0022-3565.s 34 - 41.
- Ravna, Aina Westrheim; Sylte, Ingebrigt; Dahl, Svein G.. Molecular model of the neural dopamine transporter. Journal of Computer-Aided Molecular Design 2003; Volum 17. ISSN 0920-654X.s 367 - 382.
- Brandsdal, Bjørn Olav; Heimstad, E. S.; Sylte, Ingebrigt; Smalås, Arne Oskar. Comparative Molecular Dynamics of Mesophilic and Psychrophilic Homologues Studied by 1.2 ns Simulations.. Journal of Biomolecular Structure and Dynamics 1999; Volum 17. ISSN 0739-1102.s 493 - 506.
- Baglo, Yan; Gabrielsen, Mari; Sylte, Ingebrigt; Gederaas, Odrun Arna. Homology modelling of human GABA transporters and the binding of prodrugs 5-aminolevulinic acid and its methyl ester used in photodynamic therapy. 3. Biostruct årsmøte, UiT 2012-08-30 - 2012-09-02 2012.
- Adekoya, Olayiwola; Sylte, Ingebrigt. Molecular interactions of ABT and matrix metalloproteinases. The FEBS Journal 2011; Volum 278. ISSN 1742-464X.s 322 - 322.
- Gabrielsen, Mari; Sylte, Ingebrigt; Dahl, Svein G.; Ravna, aina westrheim. A short update on the structure of drug binding sites on neurotransmitter transporters.. BMC Research Notes 2011; Volum 4. ISSN 1756-0500.s doi: 10.1186/1756-0500-4-559.
- Baglo, Yan; Gabrielsen, Mari; Sylte, Ingebrigt. Homology modelling av GABA transporter: analyse av prodrug ALA og MAL uptak. NOFFOF årsmøte 2011 2011-11-18 - 2011.
- Chilmonczyk, Zdzislaw; Kossakowski, Jerzy; Walory, Jaroslaw; Koronkiewicz, Miroslawa; Sylte, Ingebrigt; Nowak, Gabriel; Bojarski, Andrezej J. Influence of new high affinity serotonin transporter ligands on cellular cAMP levels. Pharmacological Reports 2011; Volum 63 (2). ISSN 1734-1140.s 565 - 565.
- Sjøli, Stian; Adekoya, Olayiwola; Jiang, Yang; Akselsen, O; Hansen, VT; Svineng, Gunbjørg; Sylte, Ingebrigt; Winberg, Jan-Olof. Novel Inhibitors of Matrix Metalloprotease-9 and-14. The FEBS Journal 2010; Volum 277. ISSN 1742-464X.s 265 - 265.
- Wuxiuer, Yimingjiang; Cols, N; Gonzalez-Duarte, R; Ladenstein, R; Sylte, Ingebrigt; Winberg, Jan-Olof. Kinetic characterization of the Drosophila lebanonensis ADH T114V mutant. The FEBS Journal 2010; Volum 277. ISSN 1742-464X.s 265 - 265.
- Chilmonczyk, Zdizlav; Jaronczyk, Malgorzata; Mazurek, AP; Sylte, Ingebrigt; Ravna, aina westrheim. Molecular targets for new antidepressant drugs. Pharmacological Reports 2008; Volum 60. ISSN 1734-1140.s 260 - 260.
- Orhan, I; Khan, Mahmud Tareq Hassan; Aslan, S; Kartal, M; Sener, B; Sylte, Ingebrigt. Molecular docking studies on the alkaloid (+)-buxabenzamidienine from Buxus sempervirens L. with anticholinesterase effect. Planta Medica 2008; Volum 74 (9). ISSN 0032-0943.s 1166 - 1167.
- Sylte, Ingebrigt. Molekylære mekanismer i jakten på nye legemidler - utvikling av nye antidepressive legemidler.. Onsdagsmøte 2007-11-07 - 2007.
- Sylte, Ingebrigt. Structural biology and visualization of drug targets.. Workshop on Molecular Imaging 2007-04-27 - 2007.
- Sylte, Ingebrigt. Structural visualization of molecular drug targets in the CNS.. Conference on Imaging in Neuroscience 2007-04-26 - 2007-04-27 2007.
- Gani, Osman A.B.S.M.; Sylte, Ingebrigt. Molecular recognition of fatty acids by PPAR-alpha. Open day 2006. PhD-school in Molecular and Structural Biology 2006-11-15 - 2006.
- Adekoya, Olayiwola Adedotun; Dahl, Svein G.; Gabrielsen, Mari; Gani, Osman A.B.S.M.; Khan, Mahmud Tareq Hassan; Kristiansen, kurt; Sylte, Ingebrigt; Ravna, aina westrheim; Wuxiuer, Y; Sandberg, LS. The molecular modelling group. Open day 2006. PhD-school in Molecular and Structural Biology 2006-11-15 - 2006.
- Khan, Mahmud Tareq Hassan; Adekoya, Olayiwola Adedotun; Lorentzen, marit sjo; Willassen, Nils Peder; Smalås, Arne Oskar; Sylte, Ingebrigt. Molecular features and inhibition of the thermolysin family of enzymes. Open day 2006. PhD-school in Molecular and Structural Biology 2006-11-15 - 2006.
- Jaronczyk, Malgorzata; Chilmonczyk, Zdizlav; Mazurek, AP; Dybala, M; Ravna, aina westrheim; Kristiansen, kurt; Sylte, Ingebrigt. Molecular mechanism of selective serotonin reuptake inhibitors (SSRI's) interactions with serotonin transporter. Journal of Peptide Science 2006; Volum 12. ISSN 1075-2617.s 186 - 186.
- Khan, Mahmud Tareq Hassan; Sylte, Ingebrigt. Structural bioinformatics in the discovery of novel drugs.. 9th Eurasis Conference on Chemical Sciences 2006-09-09 - 2006-09-13 2006.
- Jaronczyk, Malgorzata; Chilmonczyk, Zdizlav; Mazurek, AP; Dybala, M; Ravna, aina westrheim; Kristiansen, kurt; Sylte, Ingebrigt. Molecular mechanism of selective serotonin reuptake inhibitors (SSRI's)interactions with serotonin transporter. 29th European Peptide Symposium 2006-09-03 - 2006-09-08 2006.
- Gani, Osman A.B.S.M.; Sylte, Ingebrigt. The effect of E-Z isomerization of docosahexaeonic acid (DHA) double bonds on binding to nuclear receptors.. Docking and scoring in structure guided drug design. 2006-04-05 - 2006-04-07 2006.
- Gani, Osman A.B.S.M.; Sylte, Ingebrigt. Molecular recognition of fatty acids by PPAR-alpha.. Structure-based Drug Design 2006-06-14 - 2006-06-16 2006.
- Khan, Mahmud Tareq Hassan; Adekoya, Olayiwola Adedotun; Sylte, Ingebrigt. Sequence analysis of the assigned members of the M4 family of the peptidases compared to thermolysin, the prototype of the clan.. Bioforum 2006 2006-06-07 - 2006-06-09 2006.
- Ghani, Osman A.b.s.m; Adekoya, Olayiwola; Giuratob, L; Guccione, S; Winberg, Jan-Olof; Sylte, Ingebrigt. The catalytic mechanisms of short-chain dehydrogenases/ reductases. Horizons in Molecular Biology Decoding Nature: Hierarchy of Interactions, 2nd International PhD Student Symposium 2005-03-01 - 2005-03-02 2005.
- Strzelczyk, Anna Agnieszka; Jaronczyk, Malgorzata; Chilmonczyk, Zdizlav; Chojnacka-Wojcik, Eva; Sylte, Ingebrigt. The 5HT1A and 5HT2A serotonin receptors interactions with methylated buspirone analogues. The international conference sequence-structure-functions relationships. Thoretical and experimental approaches 2005-04-06 - 2005-04-10 2005.
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