Universitetet i Tromsø - Startsida Universitetet i Tromsø - Startsida
 
Medisinsk biologi


Sager, Georg

Professor
Medisinsk biologi

Funksjon
Professor / Medisinsk farmakologi og toksikologi

Telefon
776 44708

Epost

Kontor/besøksadresse
Medisin og Helsefag
MH L8.137
Georgs_juni_2012.jpg

Mobil privat
95089088

Stillingsbeskrivelse

Professor / Fungerende forskningsgruppeleder


Biografiske data

Utdanning: Cand. med., Dr. med., medisinsk spesialistutdanning i klinisk farmakologi

Yrkespraksis: Stipendiat (NFR), turnustjeneste, 1.amanuensis/professor, bedriftslege, assistentlege nevrologi, overlege i rusomsorg, overlege i klinisk farmakologi, avdelingsoverlege laboratoriemedisin 


Verv

Medlem av styret i fagforeningen for leger i vitenskapelige stillinger, Leder av legemiddelkomiteen UNN, Leder av Legemiddelgruppen for eldre, Sekretær og senere leder for styret i Norsk forening for klinisk farmakologi, Medlem av arbeidsutvalget for legemiddelinnkjøpssamarbeid, Medlem og senere leder av faggruppe C i Den Norske Kreftforening, nestleder for IMB, Medlem av redaksjonsutvalget i Norsk legemiddelhåndbok, Leder av den Norske lægeforenings legemiddelutvalg, Medlem av styret for Norut - Medisin og helse, Dekan for Det medisinske fakultet, Medlem av styret for Felleskatalogen, Nestleder i spesialitetskomiteen for klinisk farmakologi, Medarbeider i Tidskrift for den norske legeforening.


Forskningsinteresser

Eksperimentell og klinisk farmakologi med vekt på legemiddelbehandling av kreftsykdommer.

Nåværende forskning: ABC-transportere - Biologi og farmakologi med vinkling mot kreftsykdommer.  

Tidligere forskning: Plasma protein binding av legemidler, regulering og funksjon av beta-adrenerge reseptorer.  


Forskningsprosjekter
  • ABC-transportere – Betydning for medikamentell behandling og diagnostikk av kreftpasienter

De viktigste publikasjoner med relevans for dette prosjektet:

  • C.Schultz, S.Vaskinn, H.Kildalsen and G.Sager: “Cyclic AMP Stimulates the Cyclic GMP Egression Pump in Human Erythrocytes: Effects of Probenecid, Verapamil, Progesterone, Theophylline, IBMX, Forskolin, and Cyclic AMP on Cyclic GMP uptake and Association to Inside-Out Vesicles”. Biochemistry 37, 1161-1166 (1998).
  • E. Boadu and G. Sager: "Characterization of ATPase activity of a putative cGMP transporter in human erythrocyte ghosts, solubilized and proteoliposome reconstituted membrane extracts" BBA- Biomembranes 1509 (1-2), 467-474 (2000).
  • E.Boadu, S.Vaskinn, E.Sundkvist, R.Jaeger and G.Sager: “ Guanosine cyclic monophosphate analogues inhibit uptake of [3H]-guanosine cyclic monophosphate without stimulation of ATPase activity in human erythrocyte inside-out vesicles” Biochemical pharmacology, 62 (4), 425-429 (2001).
  • E.Sundkvist, R.Jæger and G.Sager: “Pharmacological characterization of the ATP-dependent low Km guanosine 3',5'-cyclic monophosphate (cGMP) transporter in human erythrocytes”. Biochemical Pharmacology, 63 (5), 949-953 (2002).
  • Georg Sager: Cyclic GMP transporters. Neurochemistry International, 45 (6): 865-873 (2004).
  • Aina W. Ravna, Ingebrigt Sylte and Georg Sager: "A molecular model of a putative substrate releasing conformation of multidrug resistance protein 5 (MRP5).Eur J Med Chem. Nov;43(11):2557-67 (2008).
  • Georg Sager and Aina W. Ravna: “Cellular efflux of cAMP and cGMP - A question about selectivity” Mini-Reviews in Medicinal Chemistry (MRMC) 9 (8), 1009-1013 (2009).
  • Georg Sager, Elin Øien Ørvoll, Roy Andre Lysaa, Irina Kufareva, Ruben Abagyan, and Aina Westrheim Ravna: "Novel cGMP efflux inhibitors - Identified by virtual ligand screening (VLS) and confirmed by experimental studies"  Journal of Medicinal Chemistry 55 (7):3049-57 (2012)
  • Tormod Eggen, Georg Sager, Thomas Berg, Birgitte Nergaard, Bjørn T.G. Moe and Anne Ørbo: “Increased gene expression of the ABCC5 transporter without distinct changes in the expression of PDE5 in human cervical cancer cells during growth”.  Anticancer research 32 (8), 3055- 3061 (2012)
  • Elin Ørvoll, Roy A. Lysaa, Aina W. Ravna and Georg Sager:“Misoprostol and the sildenafil analog (PHAR- 0099048) modulate cellular efflux of cAMP and cGMP differently”. Pharmacology and Pharmacy 4 (1): 104-109 (2013) E-pub Jan 30th 2013 doi:10.4236/pp.2013.41015 (http://www.scirp.org/journal/pp).


Arbeider i CRIStin

  • Ørvoll, elin peggy hanne Øien; Lyså, Roy Andre; Ravna, aina westrheim; Sager, Georg. Misoprostol and the sildenafil analog (PHAR- 0099048) modulate cellular efflux of cAMP and cGMP differently. Pharmacology and Pharmacy 2013; Volum 4 (1). ISSN 2157-9423.s 104 - 109.s doi: doi:10.4236/pp.2013.41015.
  • Filseth, Ole Magnus; How, Ole-Jakob; Kondratyev, Timofey; Gamst, Tor Magne; Sager, Georg; Tveita, Torkjel. Changes in cardiovascular effects of dopamine in response to graded hypothermia in vivo. Critical Care Medicine 2012; Volum 40 (1). ISSN 0090-3493.s 178 - 186.s doi: 10.1097/CCM.0b013e31822d78de.
  • Eggen, Tormod; Sager, Georg; Berg, Thomas; Nergaard, Birgitte; Moe, Bjørn Torvald Greve; Ørbo, Anne. Increased Gene Expression of the ABCC5 Transporter without Distinct Changes in the Expression of PDE5 in Human Cervical Cancer Cells during Growth. (fulltekst) Anticancer Research 2012; Volum 32 (8). ISSN 0250-7005.s 3055 - 3061.
  • Sager, Georg; Ørvoll, elin peggy hanne Øien; Lyså, Roy Andre; Kufareva, Irina; Abagyan, Ruben; Ravna, aina westrheim. Novel cGMP Efflux Inhibitors Identified by Virtual Ligand Screening (VLS) and Confirmed by Experimental Studies. Journal of Medicinal Chemistry 2012; Volum 55 (7). ISSN 0022-2623.s 3049 - 3057.s doi: 10.1021/jm2014666.
  • Eggen, Tormod; Sager, Georg; Arnes, Marit; Pettersen, Inger; Ørbo, Anne. Expression of iNOS - A Favourable Prognostic Marker for Early-stage Carcinoma of the Uterine Cervix. Anticancer Research 2011; Volum 31 (6). ISSN 0250-7005.s 2319 - 2325.
  • Slåtsve, Arne Martin; Ravna, aina westrheim; Lyså, Roy Andre; Sager, Georg. ABC-transportørenes betydning for effekt og omsetning av legemidler. Tidsskrift for Den norske legeforening 2011; Volum 131 (11). ISSN 0029-2001.s 1084 - 1087.s doi: 10.4045/tidsskr.10.0675.
  • Fjelldal, Renathe; Moe, Bjørn Torvald Greve; Ørbo, Anne; Sager, Georg. MCF-7 Cell Apoptosis and Cell Cycle Arrest: Non-genomic Effects of Progesterone and Mifepristone (RU-486). Anticancer Research 2010; Volum 30 (12). ISSN 0250-7005.s 4835 - 4840.
  • Ravna, aina westrheim; Sager, Georg; Dahl, Svein G.; Sylte, Ingebrigt. Membrane transporters: Structure, function and targets for drug design. Springer Publishing Company 2009 (4) ISBN 978-3-540-87911-4. ISSN 1862-2461.s 15 - 51.
  • Ravna, aina westrheim; Sager, Georg. Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance. Mini-Reviews in medical chemistry 2009; Volum 9 (2). ISSN 1389-5575.s 186 - 193.
  • Sager, Georg; Ravna, aina westrheim. Cellular Efflux of cAMP and cGMP - A Question about Selectivity. Mini-Reviews in medical chemistry 2009; Volum 9 (8). ISSN 1389-5575.s 1009 - 1013.
  • Moe, Bjørn Torvald Greve; Vereide, Anne Beate; Ørbo, Anne; Sager, Georg. High Concentrations of Progesterone and Mifepristone Mutually Reinforce Cell Cycle Retardation and Induction of Apoptosis. Anticancer Research 2009; Volum 29 (4). ISSN 0250-7005.s 1053 - 1058.
  • Ravna, aina westrheim; Sylte, Ingebrigt; Sager, Georg. Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure. Theoretical Biology Medical Modelling 2009; Volum 6 (20). ISSN 1742-4682.s doi: 10.1186/1742-4682-6-20.
  • Moe, Bjørn Torvald Greve; Vereide, Anne Beate; Ørbo, Anne; JÆger, ragnhild; Sager, Georg. Levonorgestrel, Medroxyprogesterone and Progesterone Cause a Concentration-dependent Reduction in Endometrial Cancer (Ishikawa) Cell Density, and High Concentrations of Progesterone and Mifepristone Act in Synergy. Anticancer Research 2009; Volum 29 (4). ISSN 0250-7005.s 1047 - 1052.
  • Ravna, aina westrheim; Sager, Georg. Molecular model of the outward facing state of the human multidrug resistance protein 4 (MRP4/ABCC4). Bioorganic & Medicinal Chemistry Letters 2008; Volum 18 (12). ISSN 0960-894X.s 3481 - 3483.s doi: 10.1016/j.bmcl.2008.05.047.
  • Müller, Stig; How, Ole-Jakob; Hermansen, Stig eggen; Stenberg, Thor Allan; Sager, Georg; Myrmel, truls. Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia. Critical Care 2008; Volum 12. ISSN 1466-609X.s doi: 10.1186/cc6794.
  • Ravna, aina westrheim; Sylte, Ingebrigt; Sager, Georg. A molecular model of a putative substrate releasing conformation of multidrug resistance protein 5 (MRP5). European Journal of Medicinal Chemistry 2008; Volum 43 (11). ISSN 0223-5234.s 2557 - 2567.s doi: 10.1016/j.ejmech.2008.01.015.
  • Ravna, aina westrheim; Sylte, Ingebrigt; Sager, Georg. Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5). Theoretical Biology Medical Modelling 2007; Volum 4. ISSN 1742-4682.s 33 - .
  • Ørbo, Anne; Hanevik, Målfrid; JÆger, ragnhild; Van Heusden, Saskia; Sager, Georg. Urinary cyclic GMP after treatment of gynecological cancer. A prognostic marker of clinical outcome. Anticancer Research 2007; Volum 27. ISSN 0250-7005.s 2591 - 2596.
  • Vereide, Anne Beate; Kaino, Turid; Sager, Georg; Arnes, Marit; Ørbo, Anne. Effect of levonorgestrel IUD and oral medroxyprogesterone acetate on glandular and stromal progesterone receptors (PRA and PRB), and estrogen receptors (ER-alpha and ER-beta) in human endometrial hyperplasia. Gynecologic Oncology 2006; Volum 101 (3). ISSN 0090-8258.s 214 - 223.
  • Ulvestad, Line; Sager, Georg. Syklisk GMP som biomarkør ved hjerte- og karsykdommer og kreft. Tidsskrift for Den norske legeforening 2005; Volum 125 (1). ISSN 0029-2001.s 27 - 28.
  • Kamycheva, Elena; Jorde, Rolf; Haug, E; Sager, Georg B; Sundsfjord, Johan A. Effects of acute hypercalcaemia on blood pressure in subjects with and without parathyroid hormone secretion. Acta Physiologica Scandinavica 2005; Volum 184 (2). ISSN 0001-6772.s 113 - 119.
  • Vereide, Anne Beate; Kaino, Turid; Sager, Georg B; Ørbo, Anne. Bcl-2, BAX, and apoptosis in endometrial hyperplasia after high dose gestagen therapy: A comparison of responses in patients treated with intrauterine levonorgestrel and systemic medroxyprogesterone. Gynecologic Oncology 2005; Volum 97. ISSN 0090-8258.s 740 - 750.
  • Sager, Georg B. Cyclic GMP transporters. Neurochemistry International 2004; Volum 45 (6). ISSN 0197-0186.s 865 - 873.
  • Aghajani, Ebrahim; Korvald, Christian; Nordhaug, Dag Ole; Sager, Georg B; Revhaug, Arthur; Myrmel, Truls. E. Coli sepsis induces profound mechanoenergetic inefficiency in the porcine left ventricle. Shock 2004; Volum 21 (2). ISSN 1073-2322.s 103 - 9.
  • Flaten, Magne Arve; Simonsen, Terje; Sager, Georg B. Stimulant and relaxant drugs combined with stimulant and relaxant information: a study of active placebo.. Psychopharmacology 2004; Volum 176. ISSN 0033-3158.s 426 - 434.s doi: 10.1007/s00213-004-1886-7.
  • Berthelsen, Eirin Listau; Endresen, Petter Cappelen; Ørbo, Anne; Sager, Georg B. Non-genomic cell growth inhibition by progesterone. Cell cycle retardation and induction of cell death. Anticancer Research 2004; Volum 24 (6). ISSN 0250-7005.s 3749 - 3756.
  • Boadu, Emmanuel; Sager, Georg B. Reconstitution of ATP-dependent cGMP transport into proteoliposomes by membrane proteins from human erythrocytes. Scandinavian Journal of Clinical and Laboratory Investigation 2004; Volum 64. ISSN 0036-5513.s 41 - 48.
  • Sager, Georg B; Ørbo, Anne; JÆger, ragnhild; Engström, Catharina. Non-genomic effects of progestins - Inhibition of cell growth and increased intracellular levels of cyclic nucleotides. Journal of Steroid Biochemistry and Molecular Biology 2003; Volum 84 (1). ISSN 0960-0760.s 1 - 8.
  • Evgenov, Oleg; Sager, Georg; Bjertnaes, Lars J.. Methylene blue reduces lung fluid filtration in awake endotoxemic sheep. Critical Care Medicine 2001; Volum 29 (2). ISSN 0090-3493.s 374 - 379.
  • Balteskard, L; Unneberg, K; Mjaaland, M; Sager, Georg B; Jenssen, Trond Geir; Revhaug, Arthur. Treatment with growth hormone and insulin-like growth factor-1 in septicemia: effects on carbohydrate metabolism. European Surgical Research 1998; Volum 30 (2). ISSN 0014-312X.s 79 - 94.
  • Nermoen, Ingrid; Jorde, Rolf; Sager, Georg; Sundsfjord, J.; Birkeland, Kari. Effects of exercise on hypoglycaemic responses in insulin-dependent diabetes mellitus.. Diabetes & Metabolism 1998; Volum 24 (2). ISSN 1262-3636.s 131 - 136.
  • Stokkan, Karl-Arne; Vaughan, M.K.; REITER, RJ; Folkow, Lars; Mårtensson, P.E.; Sager, Georg; Lydersen, Christian; Blix, Arnoldus S. Pineal and thyroid functions in newborn seals. General and Comparative Endocrinology 1995; Volum 98. ISSN 0016-6480.s 321 - 331.
  • Bang, Berit; Aarbakke, jarle; Sager, Georg. Epinephrine induces β-adrenergic desensitization and differentiation of HL-60 cells.. Scandinavian Journal of Clinical and Laboratory Investigation 1993; Volum 53. ISSN 0036-5513.s 311 - 315.
  • Bang, Berit; Sager, Georg; Aarbakke, jarle. Growth, differen¬tiation and the ß-adrenergic signal system of HL-60 cells. Characteri¬zation in a medium with insulin as the only added protein.. Biochemical Pharmacology 1989; Volum 38. ISSN 0006-2952.s 3723 - 3729.
  • Sager, Georg; Bang, Berit; Pedersen, Mona Irene; Aarbakke, jarle. The human promyelocytic leukemia cell (HL-60 cell) ß-adrenergic receptor.. Journal of Leukocyte Biology 1988; Volum 44. ISSN 0741-5400.s 41 - 45.
  • Sager, Georg; Bang, Berit; Pedersen, Mona Irene; Aarbakke, jarle. ß-adrenergic receptors of normal, transformed and immature leuko¬cytes.. Humana Press 1987 ISBN 0-89603-134-9.s 115 - 121.
  • Sylte, Ingebrigt; Sager, Georg. En pionerforsker. Ottar 2013 (297). ISSN 0030-6703.s 27 - 31.
  • Filseth, OM; How, Ole-Jakob; Kondratiev, Timofei; Gamst, Tor Magne; Sager, Georg; Tveita, Torkjel. DOPAMINE INFUSIONS IN NORMOTHERMIA, SEVERE HYPOTHERMIA AND DURING REWARMING: PHARMACOKINETICS AND CARDIOVASCULAR FUNCTION IN A PIG MODEL OF SURFACE COOLING AND REWARMING. Intensive Care Medicine 2010; Volum 36. ISSN 0342-4642.s S121 - S121.
  • Ørbo, Anne; Kaino, Turid; Sager, Georg; Arnes, Marit. Bcl-2, BAX and apoptosis in endometrial hyperplasia after high dose gestagen therapy A comparison of responses in patients treated with intrauterine levonorgestrel and systemic medroxyprogesterone. European Congress of Pathology 2007-09-08 - 2007.
  • Moe, Bjørn greve; Vereide, Anne Beate; Ørbo, Anne; Sager, Georg. Extranuclear steroid-initiated signaling by progestin and mifepristone: Concentration dependent inhibition of Ishikawa cell proliferation and induction of apoptosis. Virchows Archiv 2007; Volum 451. ISSN 0945-6317.s 164 - 164.
  • Ørbo, Anne; Moe, Bjørn greve; Sager, Georg; Vereide, Anne Beate. Extranuclear steroid-initiated signaling by progestin and mifepristone. European congress of Pathology 2007-09-08 - 2007.
  • Sager, Georg. Organic anion transporters, primary and tertiary transport. Farmakologisk selskaps vintermøte 2005-01-27 - 2005-01-29 2005.
  • Kamycheva, Elena; Jorde, Rolf; Haug, E; Sager, Georg B; Sundsfjord, Johan A. Effects of acute hypercalcemia on blood pressure in subjects with and without parathyroid hormone secretion. Journal of Hypertension 2005; Volum 23. ISSN 0263-6352.s S94 - S94.
  • Sager, Georg. Effects of progesterone on cGMP biokinetics. Farmakologisk selskaps vintermøte 2005-01-27 - 2005-01-29 2005.
  • Sager, Georg. Non-genomic mechanisms beyond the antiproliferative effect of progesterone. Farmakologisk selskaps vintermøte 2005-01-27 - 2005-01-29 2005.
   Se alle arbeider i CRIStin



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