Engelsk personkortUhlin-Hansen, Lars
Professor
Medisinsk biologi
Funksjon
Professor
Telefon
776 27207
Epost
Kontor/besøksadresse
UNN
UNN
Alternativ Kontaktinfo
UIT-Kontor: L8-226E (plan 8, MH-bygget)
UNN-kontor: A1-754.
Biografiske data
Cand. med. 1982 (UiT)
Dr. med. 1990 (UiT)
Spesialist i patologi 2003
Hovedstilling: professor i rettsmedisin og patologi
Bistilling: overlege, Klinisk patologi, UNN. Hovedansvar for hematopatologi og rettsmedisin
Verv
Medlem i Den rettsmedisinske kommisjon
Medlem i den nasjonale ID-gruppen (Kripos).
Forskerprofil i Cristin
Forskningsinteresser
Kreft
Ekstracellulær matriks
Matriks metalloproteinaser.
Forskningsprosjekter
Leder og deltar i flere kreftrelaterte prosjekter.
CV
Utdanning
1982: Cand.med. (MD), Universitetet i Tromsø
1990: Dr. med. (PhD), Universitetet i Tromsø
2003: Spesialist i patologi.
Yrkespraksis
1985-1987: Stipendiat, Institutt for medisinsk biologi, UiT
1987-2006: Amanuensis/førsteamanuensis, Institutt for medisinsk biologi
1991-1992: Visiting scientist, National Institutes of Health, Bethesda, USA
1996-2001: Assistentlege, Patologisk anatomisk avdeling, UNN
1997-1998: Visiting scientist, US Food and Drug Administration, Bethesda, USA
2001-d.d.: Overlege, Patologisk anatomisk avdeling/Klinisk patologi, UNN
2003: Visiting pathologist, Hotel Dieu, Paris
2004: Visiting pathologist, Medical examiners department, Miami
2006-d.d.: Professor i rettsmedisin og patologi, Institutt for medisinsk biologi, UiT
2010-2011: Visiting scientist, Retsmedicinsk institut, Københavns universitet1
Arbeider i CRIStin
- Fadnes, Bodil Irene; Husebekk, Anne; Svineng, Gunbjørg; Rekdal, Øystein; Yanagishita, Masaki; Kolset, Svein Olav; Uhlin-Hansen, Lars. The proteoglycan repertoire of lymphoid cells. Glycoconjugate Journal 2012; Volum 29 (7). ISSN 0282-0080.s 513 - 523.s doi: 10.1007/s10719-012-9427-9.
- Fadnes, Bodil Irene; Hadler-Olsen, Elin Synnøve; Sylte, Ingebrigt; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Matrix metalloproteinase complexes and their biological significance. Walter de Gruyter 2012 ISBN 978-3-11-025876-9.s 291 - 314.
- Fadnes, Bodil Irene; Uhlin-Hansen, Lars; Lindin, Inger; Rekdal, Øystein. Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells. BMC Cancer 2011; Volum 11. ISSN 1471-2407.s doi: 10.1186/1471-2407-11-116.
- Hadler-Olsen, Elin Synnøve; Fadnes, Bodil Irene; Sylte, Ingebrigt; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Regulation of matrix metalloproteinase activity in health and disease. The FEBS Journal 2011; Volum 278 (1). ISSN 1742-464X.s 28 - 45.s doi: 10.1111/j.1742-4658.2010.07920.x.
- Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Ravuri, Chandra Sekhar; Omair, Ahmad; Rikardsen, Oddveig G; Svineng, Gunbjørg; Kanapathippillai, Premasany; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Organ specific regulation of tumour invasiveness and gelatinolytic activity at the invasive front. European Journal of Cancer 2011; Volum 47 (2). ISSN 0959-8049.s 305 - 315.s doi: 10.1016/j.ejca.2010.09.006.
- Hadler-Olsen, Elin Synnøve; Winberg, Jan-Olof; Reinholt, Finn P.; Larsen, Terje; Uhlin-Hansen, Lars; Jenssen, Trond Geir; Berg, Eli; Kolset, Svein Olav. Proteases in plasma and kidney of db /db mice as markers of diabetes-induced nephropathy. ISRN Endocrinology 2011. ISSN 2090-4630.s doi: 10.5402/2011/832642.
- Ljones, Hilde; Hadler-Olsen, Elin Synnøve; Magnussen, Synnøve; Rikardsen, Oddveig G; Steigen, sonja eriksson; Sundkvist, elisabeth; Loennechen, Thrina; Kanapathippillai, Premasany; Kildalsen, hanne; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg. S100A4 Expression in Xenograft Tumors of human carcinoma cell lines is induced by the tumor microenvironment. American Journal of Pathology 2011; Volum 178 (5). ISSN 0002-9440.s 2389 - 2396.s doi: 10.1016/j.ajpath.2011.01.022.
- Malla, Nabin; Berg, Eli; Moens, Ugo; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Biosynthesis of Promatrix Metalloproteinase-9/Chondroitin Sulphate Proteoglycan Heteromer Involves a Rottlerin-Sensitive Pathway. PLoS ONE 2011; Volum 6 (6). ISSN 1932-6203.s doi: 10.1371/journal.pone.0020616.
- Hadler-Olsen, Elin Synnøve; Kanapathippillai, Premasany; Berg, Eli; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Gelatin In Situ Zymography on Fixed, Paraffin-embedded Tissue: Zinc and Ethanol Fixation Preserve Enzyme Activity. Journal of Histochemistry and Cytochemistry 2010; Volum 58 (1). ISSN 0022-1554.s 29 - 39.s doi: 10.1369/jhc.2009.954354.
- Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Rikardsen, Oddveig G; Steigen, Sonja Eriksson; Kanapathippillai, Premasany; Grenman, Reidar; Winberg, Jan-Olof; Svineng, Gunbjørg; Uhlin-Hansen, Lars. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Virchows Archiv 2010; Volum 457 (6). ISSN 0945-6317.s 677 - 692.s doi: 10.1007/s00428-010-0980-y.
- Fadnes, Bodil Irene; Rekdal, Øystein; Uhlin-hansen, lars. The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells. BMC Cancer 2009; Volum 9. ISSN 1471-2407.s doi: 10.1186/1471-2407-9-183.
- Malla, Nabin; Berg, Eli; Uhlin-hansen, lars; Winberg, Jan-Olof. Interaction of pro-matrix metalloproteinase-9/proteoglycan heteromer with gelatin and collagen. Journal of Biological Chemistry 2008; Volum 283. ISSN 0021-9258.s doi: 10.1074/jbc.M709140200.
- Malla, Nabin; Sjøli, Stian; Winberg, Jan-Olof; Hadler-Olsen, Elin Synnøve; Uhlin-hansen, lars. Biological and pathobiological functions of gelatinase dimers and complexes. Connective Tissue Research 2008; Volum 49. ISSN 0300-8207.s 180 - 184.s doi: 10.1080/03008200802151755.
- Hansen, Berit; Øynebråten, Inger; Uhlin-Hansen, Lars; Smedsrød, Bård. Endocytosis and degradation of serglycin in liver sinusoidal endothelial cells. Molecular and Cellular Biochemistry 2006; Volum 287. ISSN 0300-8177.s 43 - 52.
- Jenssen, Håvard; Andersen, Jeanette Hammer; Uhlin-Hansen, Lars; Gutteberg, Tore Jarl; Rekdal, Øystein. Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfate. Antiviral Research 2004; Volum 61. ISSN 0166-3542.s 101 - 109.
- Winberg, Jan-Olof; Berg, Eli; Kolset, S O; Uhlin-Hansen, Lars. Calcium- induced activation and truncation of promatrix metalloproteinase-9 covalently linked to the core protein of chondroitin sulfate proteoglycans. European Journal of Biochemistry 2003; Volum 270. ISSN 0014-2956.s 3996 - 4007.
- Pejler, G; Winberg, Jan-Olof; Vuong, TT; Henningsson, F; Uhlin-Hansen, Lars; Kimata, K; Kolset, S O. Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans. European Journal of Biochemistry 2003; Volum 270. ISSN 0014-2956.s 3971 - 3980.
- Dupuy, Berit Myhre; Perchla, Dorota; Markussen, Gunnar; Rognum, Torleiv Ole; Uhlin-Hansen, Lars; Nordrum, Ivar Skjåk; Morild, Inge; Stenersen, Marguerethe. DNA-analysis for DVI or other identification purposes. Evaluation of the COPAN 4N6FLOQSwabs™ for collection of blood or tissue samples from deceased individuals. ISHI 23 International Symposium on Human Identification 2012-10-15 - 2012-12-18 2012.
- Stray-Pedersen, Arne; Rogde, Sidsel; Ormstad, Kari; Vege, Åshild; Delavaris, Gerd Jorunn; Skjerven-Martinsen, Marianne; Uhlin-Hansen, Lars; Nordrum, Ivar Skjåk; Morild, Inge; Lycke-Ellingsen, Christian; Holck, Per; Mynarek, Georg; Bosse, Gerhard; Rognum, Torleiv Ole. Forensic medical examination after the July 22nd 2011 terror attack. 18th Nordic Conference on Forensic Medicine 2012-06-13 - 2012-06-16 2012.
- Hadler-Olsen, Elin Synnøve; Solli, Ann Iren; Fadnes, Bodil Irene; Uhlin-Hansen, Lars; Winberg, Jan-Olof. Tissue localization of intracellular gelatinolytic activity. The FEBS Journal 2012; Volum 279. ISSN 1742-464X.s 566 - 566.
- Hadler-Olsen, Elin Synnøve; Ravuri, Chandra Sekhar; Wetting, Hilde Ljones; Rikardsen, Oddveig G; Steigen, sonja eriksson; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-Hansen, Lars. Stromal Impact on Tumor Invasiveness and Gelatinolytic Activity at the Invasive Front. FEBS Advanced Lecture Course 2011matrix Pathobiology, Signalling and Molecular Targets 2011-09-02 - 2011-09-07 2011.
- Hadler-Olsen, Elin Synnøve; Ravuri, Chandra Sekhar; Ljones, Hilde; Rikardsen, Oddveig G; Steigen, sonja eriksson; Svineng, Gunbjørg; Winberg, Jan-Olof; Uhlin-hansen, lars. Organ specific stromal influence on tumor invasiveness and proteolytic activity at the invasive front. European Journal of Cancer 2010. ISSN 0959-8049.s doi: 10.1111/j.1600-0463.2009.02578.x.
- Hadler-Olsen, Elin Synnøve; Ljones, Hilde; Rikardsen, O; Steigen, sonja eriksson; Winberg, Jan-Olof; Svineng, Gunbjørg; Uhlin-Hansen, Lars. Stromal impact on tumor growth and lymphangiogenesis in human carcinoma xenografts. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS) 2010; Volum 118 (3). ISSN 0903-4641.s 245 - 245.
- Malla, Nabin; Berg, Eli; Uhlin-hansen, lars; Winberg, Jan-Olof. Binding of promatrix metalloproteinase-9/ chondroitin sulphate proteoglycan complex to ECM. The XX FECTS Meeting 2006-07-01 - 2006-07-05 2006.
- Berg, Eli; Uhlin-Hansen, Lars; Kolset, S O; Winberg, Jan-Olof. The interaction between proMMP-9 and a proteoglycan core protein causes an intramolecular autoactivation in the presence of calcium. NBS kontaktmøte 2005-01-13 - 2005.
- Berg, Eli; Malla, Nabin; Uhlin-Hansen, Lars; Kolset, S O; Winberg, Jan-Olof. The matrix metalloproteinase-9 / chondroitin sulphate proteoglycan complex is produced from cells stimulated with the phorbolester PMA. NBS kontaktmøte 2005-01-13 - 2005-01-16 2005.
- Berg, Eli; Malla, Nabin; Uhlin-Hansen, Lars; Kolset, S O; Winberg, Jan-Olof. The matrix metalloproteinase-9 / chondroitin sulphate proteoglycan complex is produced from cells stimulated with the phorbolester PMA. The XIXth FECTS Meeting 2004-07-09 - 2004-07-13 2004.
- Pejler, G; Henningsson, F; Winberg, Jan-Olof; Vuong, TT; Uhlin-Hansen, Lars; Kimata, K; Kolset, S O. Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans. Experimental Biology 2003 Meeting 2003-04-11 - 2003-04-15 2003.
