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Engelsk personkort


Paulssen, Ruth H

Professor
Klinisk medisin

Funksjon
Professor

Telefon
776 45480

Epost

Kontor/besøksadresse
Medisin og Helsefag
MH L6.226

Mobil privat
+47 40479347

Alternativ Kontaktinfo

ruthpau@online.no


Stillingsbeskrivelse

Professor i molekylær biologi og genteknologi

Leder for Microarray Resource Centre Tromsø (MRCT)


Biografiske data

 

  1. Hracky, R. and J. Soll: PROTEIN PHOSPHORYLATION-DEPHOSPHORYLATION IN THE CYTOSOL OF PEA MESOPHYLL CELLS. Zeitschrift für Naturforschung C – A Journal of Biosciences (1986) 41(9-10):865-860.
  2. Schindler, C., R. Hracky and J. Soll: PROTEIN TRANSPORT IN CHLOROPLASTS: ATP IS PREREQUISIT. Zeitschrift für Naturforschung C – A Journal of Biosciences (1987) 42c (1-2):103-108.
  3. J.O. Gordeladze, E.J. Paulssen and R. Hracky: G-PROTEINS AND THEIR INVOLVEMENT IN HORMONAL SIGNAL TRANSDUCTION. Scand.J.Clin.Lab.Invest. Suppl. (1990) 202:127-130.
  4. R. H. Paulssen, E.J. Paulssen, P. Aleström, J.O. Gordeladze and K.M. Gautvik: SPECIFIC ANTISENSE RNA INHIBITION OF GROWTH HORMONE PRODUCTI­ON IN DIFFERENTIATED RAT PITUITARY TUMOR CELLS. Biochem.Biophys.Res.Commun. (1990) 171:293-300.
  5. R. H. Paulssen, E.J. Paulssen, P. Aleström and K.M. Gautvik: ELECTROPORATION OF RAT PITUITARY CELL LINES (GH CELLS)-OPTIMAL PARAMETERS AND EFFECTS ON ENDOGENOUS HORMONE PRODUCTION. Biochem.Biophys.Res.Commun. (1990) 171:1029-1036.
  6. RH. Paulssen, E.J. Paulssen, K.M. Gautvik and J.O. Gordeladze: HORMONE RECEPTOR-EFFECTOR COUPLING IN PROLACTIN PRODUCING PITUITARY CELL LINES (GH CELLS). In: Biological Signal Transduction, eds: E.M. Ross and K.W.A. Wirtz, NATO ASI Series H, Vol. 52, (1991), 179-191.
  7. Paulssen, E.J., Paulssen, R.H., Haugen, T.B., Gautvik, K.M. and Gordeladze, J.: CELL SPECIFIC DISTRIBUTION OF GUANINE NUCLEOTIDE-BINDING REGULATORY PROTEINS IN RAT PITUITARY CELL LINES. Mol.Cell.En­docrinol. (1991) 76:45-53.
  8. R.H. Paulssen, E.J. Paulssen, J.O. Gordeladze, V. Hansson and T.B. Haugen: CELL SPECIFIC EXPRESSION OF GUANINE NUCLEOTIDE-BINDING PROTEINS (G PROTEINS) IN RAT TESTICULAR CELLS. Biol.Reprod. (1991) 45:566-571.
  9. E.J. Paulssen, R.H. Paulssen, T.B. Haugen, K.M. Gautvik and J.O. Gordeladze: REGULATION OF G PROTEIN mRNA LEVELS BY THYROLIBERIN, VASOACTIVE INTESTINAL POLYPEPTIDE AND SOMATOSTATIN IN PROLACTIN-PRODUCING RAT PITUITARY ADENOMA CELLS. Acta Physiol.Scand. (1991) 143:195-201.
  10. E.J. Paulssen, R.H. Paulssen, K.M. Gautvik and J.O. Gordeladze: HYPO­THALAMIC HORMONES MODULATE G PROTEIN LEVELS AND SECOND MESSENGER RESPONSIVENESS IN GH3 PITUITARY TUMOR CELLS. Biochem.Pharmacol. (1992) 44:471-477.
  11. R. H. Paulssen, E.J. Paulssen, K.M. Gautvik and J.O.Gordeladze: THE THYROLIBERIN RECEPTOR INTERACTS DIRECTLY WITH A STIMULATORY GUANINE NUCLEOTIDE-BINDING PROTEIN IN THE ACTIVATION OF ADENYLYL CYCLASE IN GH3 PITUI­TARY TUMOR CELLS: EVIDENCE OBTAINED BY THE USE OF ANTISENSE RNA INHIBITION AND IMMUNO­BLOCKING OF THE STIMULATORY GUANINE-NUCLEOTIDE-BINDING PROTEIN. Eur.J.Biochem. (1992) 204:413-418.
  12. R.H. Paulssen, E.J. Paulssen, K.M. Gautvik and J.O. Gordeladze: MODULATION OF G PROTEINS AND SECOND MESSENGER RESPONSIVENESS BY STEROID HORMONES IN GH3 RAT PITUITARY TUMOUR CELLS. Acta Physiol.Scand (1992) 146:511-518.
  13. E..J. Paulssen, R.H. Paulssen, K.M. Gautvik and J.O. Gordeladze: "CROSS-TALK" BETWEEN PHOSPHOLIPASE C AND ADENYLYL CYCLASE IN GH3 RAT PITUITARY TUMOR CELLS. Cellular Signalling (1992) 4:747-755.
  14. R.H. Paulssen and E.J. Paulssen: G-PROTEIN COUPLED TRANSMEMBRANE SIGNALLING IN PROLACTIN-PRODUCING RAT PITUITARY TUMOUR CELLS. Thesis (1992), Institute of Medical Biochemistry, University of Oslo, Oslo, Norway.
  15. R.H. Paulssen and E.J. Paulssen: "ANTISENSE MAKES SENSE". Medlemsblad for Norsk Biokjemisk Selskap (NBS) (1993) 1:7-8.
  16. J.O. Gordeladze, G. Jablonski. R.H. Paulssen, E.J. Paulssen, B. Mortensen, K.M. Gautvik, E. Haug, E. Rian, R. Jemtland, E. Friedman and Ø.S. Bruland: G-PROTEIN COUPLED SIGNALING IN OSTEOSARCOMA CELL LINES. In: Frontiers of Osteosarcoma Research: Interdisciplinary Survey of Clinical and Research Advances, eds: J.F. Novak and J.H. Masters, Hogrefe and Huber Publishers, (1993), pp 297-302.
  17. T.B. Haugen, R.H. Paulssen and V. Hansson: CELL-SPECIFIC EXPRESSION OF Gq/G11 PROTEIN AND mRNA IN RAT SEMINIFEROUS TUBULES. FEBS Letters (1993) 329:96-98.
  18. R.H. Paulssen, P.W. Johansen, J.O. Gordeladze, E. Paulssen, Ø. Nymoen and K.M. Gautvik: CELL-SPECIFIC EXPRESSION AND FUNCTION OF ADENYLYL CYCLASES IN DIFFERENT RAT PITUITARY TUMOUR CELL LINES IN CULTURE. Eur.J.Biochem. (1994), 222:97-103.
  19. J.O. Gordeladze, P.W. Johansen, R.H. Paulssen, E.J. Paulssen and K.M. Gautvik: G-PROTEINS: IMPLICATIONS FOR PATHOPHYSIOLOGY AND DISEASE. Eur.J.Endocrinol. (1994), 131:557-574.
  20. B.M. Mortensen, H.W. Lund, G. Jablonski, R.H. Paulssen and J.O. Gordeladze: DIRECT EFFECTS OF VITAMIN D3 ANALOGUES ON G-PROTEIN MEDIATED SIGNALLING SYSTEMS IN RAT OSTEOSARCOMA CELLS AND RAT PITUITARY ADENOMA CELLS. Biosci.Rep. (1995), 15:135-150.
  21. R.H. Paulssen, E.J. Paulssen and K.M. Gautvik: ELECTROPORATION OF RAT PITUITARY CELLS. Methods Mol.Biol. (1995), 48:123-131.
  22. R.H. Paulssen, J. Woodson, Z. Liu and E.M. Ross: CARBOXYL-TERMINAL FRAGMENTS OF PHOSPHOLIPASE C-b1 WITH INTRINSIC Gq  GTPase-ACTIVATING PROTEIN (GAP) ACTIVITY. J.Biol.Chem. (1996), 271:26622-26629
  23. J.O. Gordeladze, T.Haugen, E.J. Paulssen and R.H. Paulssen: PHOSPHOLIPASE C ACTIVATION IN RAT PITUITARY ADENOMA (GH) CELLS. Biosci.Rep. (1997), 16:65-74.
  24. J.-B. Hansen, B. Svensson, R. Olsen, M. Ezban, B. Østerud and R.H. Paulssen: HEPARIN INDUCES SYNTHESIS AND SECRETION OF TISSUE FACTOR PATHWAY INHIBITOR FROM ENDOTHELIAL CELLS IN VITRO. Thromb.Haemostasis (2000), 83:937-43.
  25. R.H. Paulssen, N. Fraeyman and J. Florholmen: ACTIVATION OF PHOPHOLIPASE C BY CCK RECEPTOR SUBTYPES WITH DIFFERENT G PROTEIN-COUPLING SPECIFICITIES IN HORMONE SECRETING PANCRETIC CELL LINES. Biochem.Pharmacol. (2000), 60:865-875.
  26. L. Thommesen, E. Hofsli, R.H. Paulssen, M.W. Anthonsen, and A. Lægreid: MOLECULAR MECHANISMS INVOLVED IN GASTRIN MEDIATED REGULATION OF cAMP-RESPONSIVE (CRE) PROMOTOR ELEMENT. Am.J.Physiol.Endocrinol.Metab. (2001), 281, E1316-E1325.
  27. P.W. Johansen, R.H. Paulssen, T. Bjøro, K.M. Gautvik and J.O. Gordeladze: DISTINCT GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA-SUBUNIT RECEPTOR COUPLING IN GH CELL LINES: EFFECTS OF BROMOCRIPTINE AND HORMONES ON EFFECTOR ENZYME MODULATION.  Cell. Physiol. Biochem. (2001), 11: 339-352.
  28. O. Ilkaeva, L.N. Kinch, R.H. Paulssen and E.M. Ross: MUTATIONS OF THE CARBOXYL TERMINAL DOMAIN OF PHOSPHOLIPASE C-b1 DELINEATE THE DIMER INTERFACE AND A POTENTIAL Gaq INTERACTION SITE.  J. Biol. Chem. (2002), 277: 4294-4300.
  29. N. Fræyman, J. Van Emmelo, R.H. Paulssen and K. Vermis: DESENSITISATION OF M3-MUSCARINIC RECEPTORS. Receptors & Channels (2004), 10:1-10.          
  30. E.Brodin, B. Svensson, R.H. Paulssen, A. Nordøy and J.-B. Hansen: INTRAVASCULAR METABOLISM AND URINARY EXCRETION OF TISSUE FACTOR PATHWAY INHIBITOR DURING HEPARIN TREATMENT. J. Lab. Clin. Res. (2004), 144:246-253.
  31. Ruth H. Paulssen, Lotte Olsen, Thea Charlotte Sogn: MagNA PURE COMPACT RNA ISOLATION KIT: ISOLATION OF HIGH QUALITY RNA FROM A BRAOD RANGE OF SAMPLE MATERIAL. Biochemica (2006), 2:14-16.
  32. R.H. Paulssen, B. Moe, H. Grønass, A. Ørbo: GENE EXPRESSION IN ENDOMETRIAL CANCER CELLS (ISHIKAWA) AFTER SHORT TIME HIGH DOSE EXPOSURE TO PROGESTINS. Virchows Archiv (2007), 451, No. 2, 163-164.
  33. V. Sitras*, R.H. Paulssen*, H. Grønaas and G. Acharya: GENE EXPRESSION PROFILE IN LABORING AND NON-LABORING HUMAN PLACENTA NEAR TERM. Mol. Hum. Reprod. (2008), 14:61-65.  *Both authors contributed equally to this work.
  34. R.H. Paulssen, B. Moe, H. Grønaas and A. Ørbo:  GENE EXPRESSION IN ENDOMETRIAL CANCER CELLS (ISHIKAWA) AFTER SHORT TIME HIGH DOSE EXPOSURE TO PROGESTERONE. Steroids (2008), 73:116-128.
  35. V. Sitras*, R.H. Paulssen*, H. Grønaas, J. Leirvik, T.A. Hansen, Å. Vårtun and G. Acharya: DIFFERENTIAL PLACENTAL GENE EXPRESSION IN SEVERE PREECLAMPSIA. Placenta (2009), 5:424-433. *Both authors contributed equally to this work.
  36. A. Ørbo, B.T. Moe, H. Grønaas, and R.H. Paulssen:  EARLY EFFECTS OF HIGH CONCENTRATIONS OF PROGESTERONE AND MIFEPRISTONE: A GENE EXPRESSION STUDY OF ENDOMETRIAL CANCER CELLS (ISHIKAWA). J. Steroids Biochem. Mol. Biol. (2009), 113:139-149.
  37. V. Sitras*, R. Paulssen*, J. Leirvik, Å. Vårtun and G. Acharya: PLACENTAL GENE EXPRESSION IN INTRAUTERINE GROWTH RESTRICTION DUE TO PLACENTAL INSUFFICIENCY. Reprod. Sci. (2009), 16:701-711. *Both authors contributed equally to this work
  38. V. Dumeaux, K.S. Olsen, G. Nuel, R.H. Paulssen, A.-L. Børresen-Dale and E- Lund: DECIPPHERING NORMAL BLOOD GENE EXPRESSION VARIATION – THE NOWAC POSTGENOME STUDY.  PLoS Genet. (2010), 6 (3): e1000873.
  39. K. Snipstad*, C.G. Fenton*, J. Kjæve, E. Anderssen, G. Lui and R.H. Paulssen: NEW SPECIFIC MOLECULAR TARGETS FOR RADIO-CHEMOTHERAPY OF RECTAL CANCER. Mol. Oncol. (2010), 4:.52-64. *Both authors contributed equally to this work.
  40. H.L. Pedersen,  E. Hjerde, S.M. Paulsen, H. Hansen, L. Olsen, S.K. Thode, M.T. Dos Santos, R.H. Paulssen, N.-P. Willassen and P. Haugen: GLOBAL RESPONSES OF Aliivibrio salmonicida TO HYDROGEN PEROXIDE AS REVEALED BY MICROARRAY ANALYSIS. Marine Genomics (2010), 3:193-200.
  41. H.L. Pedersen, G.Å. Hansen, H. Hansen, E. Hjerde, H.L. Pedersen, M.L.J. Nyrud, A. Strauss, R.H. Paulssen, N.-P. Willassen and P. Haugen: PREDICTION, MICROARRAY AND NORTHERN BLOT ANALYSES IDENTIFY NEW INTERGENIC SMALL RNAs IN Aliivibrio salmonicida.  PLoS ONE (2012), in press.
  42. V. Sitras, C. Fenton, R. Paulssen, A. Vårtun and G. Acharya: DIFFERENCES IN GENE EXPRESSION BETWEEN FIRST AND THIRD TRIMESTER HUMAN PLACENTA: A MICROARRAY STUDY.  PLoS ONE (2012), 7(3): e33294.
  43. T. Hellevik, I. Pettersen, V. Berg, J.-O. Winberg, K. Bartnes, R.H. Paulssen, L.-T. Busund, R. Bremnes,A. Chalmers and I. Martinez-Zubiaurre: CANCER-ASSOCIATED FIBROBLASTS FROM HUMAN NSCLC SURVIVE ABLATIVE DOSES OF RADIATION BUT THEIR INVASIVE CAPACITY IS REDUCED. Radiation Oncol. (2012), 7(1):59.
  44. Inigo Martinez-Zubiaurre, Christopher G. Fenton, Hagar Taman, Ingvild Pettersen, Turid Hellevik and Ruth H. Paulssen: TUMORIGENIC RESPONSES OF CANCER-ASSOCIATED STROMAL FIBROBLASTS AFTER ABLATIVE RADIOTHERAPY: A TRANSCRIPTOME-PROFILING STUDY. Journal of Cancer Therapy (2013), 4:208-250.
  45. K. Standahl-Olsen, C. Fenton, L. Frøyland, M. Waaseth, R.H. Paulssen and E. Lund: PLASMA FATTY ACID RATIOS AFFECT GENE EXPRESSION PROFILES: A CROSS-SECTIONAL STUDY OF THE NORWEGIAN WOMEN AND CANCER POST-GENOME COHORT. PloS One (2013), in press.

Verv

Leder av Microarray Resource Centre Tromsø (MRCT) ved UiT (siden 2002).

Medlem av den regionale FUGE-N faggruppen (2002-2005).

Programstyremedlem for Molekylær medisin og genteknologi ved Norges Forskningsråd (2002-2005).

Jurymedlem av den vitenskapelige komiteen til “van Gysel Price for Biomedical Research in Europe”, Brussels, Belgia, (2003).

Medlem av Evaluation Committee of the Sixth European Community Framework Program in “Molecular Medicine and Gene Technology”, (2003-2005).

Styremedlem av den regionale FUGE plattformen:”National Network for Genome-Scale Analysis of Gene Structure and Function: The Norwegian Microarray Consortium (NMC), (2004-2006).

Co-grunnlegger av “Women in Life Sciences (WiLS) database http://wils.database.embo.org, (2009)

Leder av den regionale FUGE-N faggruppen, (2006-2012).

Medlem av Executive Committee of Federation of European Biochemical Societies (FEBS), (www.febs.org), (2008-2011).

Styreleder av FEBS/EMBO “Working Group for Women in Science (WISE)”, (2008-2011).

Styreleder av FEBS/EMBO “WISE Award Selection Committee”, (2008-2012).

Medlem av FEBS Scientific Advisory Board (2008-2010).

Medlem av “Expert Panel of the genSet Initiative in the 7th European Framework Program” (www.genderinscience.org), (2009-2011).

Medlem av EU prosjekt “Transcriptomics in Cancer Epidemiology (TICE)” ved European Research Council (ERC), (siden 2008)

Medlem av evalueringspanelet (Bio-2; Bio-1) av “Research Council for Biosciences and Environment (RCBE)” ved Academy of Finland, (siden 2010)


Forskningsprosjekter

1) Characterization of epigenetic landscapes in ulcerative colitis induced cancer pathways

2) Epigenetic landscapes in families with inflammatory bowel disease

3) The Norwegian women and cancer study (NOWAC) - Expression profiles in normal breast tissue


Andre publikasjoner

R.H. Paulssen, E.J. Paulssen, J.O. Gordeladze and K.M. Gautvik: THE ELUCIDATION OF RECEPTOR-EFFECTOR COUPLING IN RAT PITUITARY (GH3) CELLS BY THE USE OF ANTISENSE TECHNIQUES. J.Cell.Biochem. (1991) Suppl. 15D:26.

G. Jablonski, B.M. Mortensen, R.H. Paulssen, H.W. Lund and J.O. Gordeladze: THE EFFECT OF UREMIA AND ALUMINIUM INTOXICATION ON HORMONE SIGNALING IN THE OSTEOBLAST. J. Bone Miner. Res. (1992), 7 Suppl. 1:225.

R.H. Paulssen, N. Fraeyman and J. Florholmen: ACTIVATION OF PHOPHOLIPASE C BY CHOLECYSTOKININ IN INSULIN (b-TC3)-, SOMATOSTATIN (Rin1027-B2)- AND GLUCAGON (INR1-G9)- SECRETING PANCREATIC CELL LINES: IDENTIFICATION OF DIFFERENT CCK-RECEPTOR SUBTYPES AND G PROTEIN-COUPLING SPECIFICITIES. FASEB J. (1997), 11 Suppl. 9: 2767.

N.V. Ermakova, R.H. Paulssen and J. Florholmen: THE EFFECT OF TNF-a ON CELL GROWTH AND PLC-g EXPRESSION IN INSULIN-SECRETING b-CELLS. Diabetologia (1999), 42:529.

 J.B. Hansen, B. Svensson, B. Østerud, R. Olsen, M. Ezban and R.H. Paulssen: HEPARIN INDUCES SYNTHESIS AND SECRETION OF TISSUE FACTOR PATHWAY INHIBITOR (TFPI) FROM ENDOTHELIAL CELLS IN VITRO. Thromb. Haemostasis (1999), Suppl. 92.

N.V. Evgenov, R.H. Paulssen, O.V. Evgenov, I. Christiansen and J. Florholmen: TUMOR NECROSIS FACTOR-a INDUCES APOPTOSIS IN AN INSULIN-SECRETING b-CELL LINE. Diabetes Res.Clin.Practice (2000), 50:S150.

R. H. Paulssen, J. Sørli, N.V. Evgenov and S. Krum-Hansen: REGULATION AND EXPRESSION OF PROTEIN KINASE C ISOFORMS BY CHOLECYSTOKININ AND GASTRIN IN A SOMATOSTATIN-SECRETING PANCRETIC Rin1027-B2 CELL LINE. Eur.J.Biochem (2001), 268, Suppl. 1:103.

N. Fraeyman and R. Paulssen: CENTRAL ROLE OF PKCa IN THE DESENSITISATION OF M3-MUSCARINIC RECEPTORS. Eur.J.Biochem. (2001), 268, Suppl. 1: 92.

L. Thommesen, E. Hofsli, R.H. Paulssen, M.W. Anthonsen, and A. Lægreid: MOLECULAR MECHANISMS INVOLVED IN GASTRIN MEDIATED REGULATION OF cAMP-RESPONSIVE (CRE) PROMOTOR ELEMENT. Am.J.Physiol. – Endocrinol. And Metab. APStracts (2001), 8:0201E.

E. Mortensen, L. Hansen, N. Bjurstam, S. Klenow, J.O. Frantzen and R.H. Paulssen: IMPRINT OF CORE BIOPSIES AS A RELIABLE DIAGNOSTIC TOOL IN BREAST CANCER AND POSSIBLE USEFULNESS FOR RESEARCH PURPOSES. Breast Cancer Res. (2005), 7, Suppl.  2:33.

R.H. Paulssen, L. Olsen, and T.C. Sogn: MagNA PURE COMPACT RNA ISOLATION KIT: ISOLATION OG HIGH-QUALITY TOTAL RNA SAMPLES FROM A BROAD RANGE OF SAMPLE MATERIAL. Biochemica (2006), 2:14-16.

V. Sitras, R.H. Paulssen, H. Grønaas, and G. Acharya: GENE EXPRESSION PROFILE IN LABORING AND NON-LABORING PLACENTA NEAR TERM.  Am. J. Obst. Gynecol. (2007), 195, Suppl. S197.

V. Dumeaux, K.S. Olsen, J. Leirvik, R.H. Paulssen, A.L. Borresen-Dale, and E. Lund: VARIATION OF GENE EXPRESSION PROFILES IN WHOLE BLOOD FROM A LARGE REPRESENTATIVE SAMPLE OF POSTMENOPAUSAL NORWEGIAN WOMEN. Eur. J. Cancer (2008), 6, Suppl. 9:97.

K.S. Olsen, C.G. Fenton, E. Anderssen, L. Frøyland, R.H. Paulssen, and E. Lund: ASSOCIATIONS BETWEEN SERUM LINOLENIC ACID/ALPHA-LINOLENIC ACID RATIO AND BLOOD GENE EXPRESSION PROFILES, FEBS J. (2009), 276, Suppl. 1:115-116.

K. Snipstad, C.G. Fenton, J. Kjæve, E. Anderssen and R.H. Paulssen: NEW SPECIFIC MOLECULAR TARGETS FOR RADIOCHEMOTHERAPY IN COLORECTAL CANCER, FEBS J. (2009), 276, Suppl. 1:121.

T. Lund, M.B. Hals, R.H. Paulssen, and K. Ytrehus: INCREASED GENE EXPRESSION DIVERSITY BETWEEN FEMALE AND MALE MICE HEARTS AFTER TRANSVERSE AORTIC CONTRICTION (TAC). Eur. J. Heart Failure Supplements (2009), 8 (2).

K.S. Olsen, C. Fenton, E. Anderssen, L. Frøyland, R.H. Paulssen, V. Dumeaux, and E. Lund: EEFECTS OF PLASMA FATTY ACID RATIOS ON THE BLOOD TRANSCRIPTOME. Norwegian Journal of Epidemiology (2009), 19: Suppl. 1:9.

V. Sitras, C. Fenton, R.H. Paulssen, A. Vårtun and G. Acharya: GLOBAL PLACENTAL GENE EXPRESSION PROFILING IN THE FIRST AND THIRD TRIMESTERS OF NORMAL HUMAN PREGNANCY. Placenta (2011), 32: A136, P2.117.

Electro Cell Manipulator Ô, ECMâ600 Electroporation Protocol 0055, BTX Dicision of  GenetronicsÓ (BTX ID #1130).

Compendium to User Course  “Introduction to Microarray Technology and Data Analysis” (Annual Issues 2004 -2010).

 FEBS News, Issue 5, September 2008, p. 11.

 FEBS News, Issue 5, October 2009, p. 8-9.

 FEBS News, Issue 4, October 2010, p. 8.

Compendium to User Course “Introduction to High-Throughput Genomics and Data Analysis” (2012).

 


Priser og utmerkelser

1986: «Stipendium zur Förderung des Wissenschaftlichen  und Künstlerischen Nachwuchses in Bayern» fra regeringen av Bayern, Tyskland, (to år).

1993:  «International Long-term Fellowship» fra The Human Frontiers Science Program Organization (HFSPO), (to år).


CV

Name:                        Ruth Hracky Paulssen

Date of Birth:            30.08.57

Nationality:            German

Marital status:          Married, two children

Education

1986:               Diploma in Biochemistry at University of Hannover, Germany. Diploma work at the Botanical Institute, Ludwig-Maximillians University Munich, Germany. Title: «Phosphorylation/Dephosphorylation in the Cytosolof Pea Mesophyll cells».

1992:               Ph.D., University of Oslo. Thesis title: «G protein-coupled Transmembrane Signalling in Prolactin-Producing rat Pituitary Tumour Cells».

 Appointments

1981 – 1984:   Research Assistant at the Institute of Clinical Chemistry, Veterinary University Hannover, Germany.

1985 – 1987:   Student Fellow, Botanical Institute, Ludwig-Maximillians University Munich, Germany.

1986:             Research Assistant, Botanical Institute, Ludwig-Maximillians University Munich, Germany.

1988:             Bioengineer, Institute of Medical Biochemistry, University of Oslo, Norway.

1989-1993:     Ph.D. Student (The Norwegian Cancer Society Fellowship), Institute of Medical Biochemistry, University of Oslo, Norway.

1993-1995:     Post doctoral Fellow (The Human Frontier Science Program Organization, HFSPO Long-term Fellowship), Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, USA.

1996-1998:     Research Scientist, Institute of Clinical Medicine, University of Tromsø, Norway.

1999-2004      Associate professor, Institute of Clinical Medicine, Laboratory of Molecular Medical Research, University of Tromsø and University Hospital of North Norway (UNN), Tromsø, Norway.

Since 2005      Professor, Department of Clinical Medicine, Laboratory of Molecular Medical Research, University of Tromsø, Tromsø, Norway.

Since 2008      Additional 20% engagement at UNN (Head of  MRCT faciltiy).


Hjemmesider
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Arbeider i CRIStin

  • Sitras, Vasilis; Fenton, Christopher Graham; Paulssen, Ruth H; Vårtun, Åse; Acharya, Ganesh. Differences in Gene Expression between First and Third Trimester Human Placenta: A Microarray Study. PLoS ONE 2012; Volum 7 (3). ISSN 1932-6203.s doi: 10.1371/journal.pone.0033294.
  • Hellevik, Turid; Pettersen, ingvild; Berg, Vivian; Winberg, Jan-Olof; Moe, Bjørn Torvald Greve; Bartnes, Kristian; Paulssen, Ruth H; Busund, Lill-Tove; Bremnes, Roy M.; Chalmers, Antony; Martinez, Inigo Zubiavrre. Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced. Radiation Oncology 2012; Volum 7. ISSN 1748-717X.s doi: 10.1186/1748-717X-7-59.
  • Dumeaux, vanessa; Olsen, Karina Standahl; Nuel, G; Paulssen, Ruth H; Børresen-Dale, Anne-Lise; Lund, Eiliv. Deciphering Normal Blood Gene Expression Variation-The NOWAC Postgenome Study. PLoS Genetics 2010; Volum 6 (3). ISSN 1553-7390.s doi: 10.1371/journal.pgen.1000873.
  • Pedersen, hege lynum; Hjerde, erik; Paulsen, steinar; Hansen, Hilde; Olsen, Lotte; Thode, Sunniva Katharina; Dos Santos, Marcos Tadeu; Paulssen, Ruth H; Willassen, Nils P; Haugen, Peik. Global responses of Aliivibrio salmonicida to hydrogen peroxide as revealed by microarray analysis. Marine Genomics 2010; Volum 3. ISSN 1874-7787.s 193 - 200.s doi: 10.1016/j.margen.2010.10.002.
  • Snipstad, Kristin; Fenton, Christopher Graham; Kjæve, Jørn; Cui, Guanglin; Anderssen, Endre; Paulssen, Ruth H. New specific molecular targets for radio-chemotherapy of rectal cancer. Molecular Oncology 2010; Volum 4 (1). ISSN 1574-7891.s 52 - 64.s doi: 10.1016/j.molonc.2009.11.002.
  • Ørbo, Anne; Moe, Bjørn Torvald Greve; Grønaas, Halvor; Paulssen, Ruth H. Early effects of high concentrations of progesterone and Mifepristone. A gene expression study of endometrial cancer cells (ishikawa). Journal of Steroid Biochemistry and Molecular Biology 2009; Volum 113 (1-2). ISSN 0960-0760.s 139 - 149.s doi: 10.1016/j.jsbmb.2008.12.003.
  • Sitras, Vasilis; Paulssen, Ruth H; Grønaas, Halvor; Leirvik, Jørn; Hanssen, Tor-Arne; VÅrtun, Åse; Acharya, Ganesh. Differential Placental Gene Expression in Severe Preeclampsia. Placenta 2009; Volum 30 (5). ISSN 0143-4004.s 424 - 433.s doi: 10.1016/j.placenta.2009.01.012.
  • Sitras, Vasilis; Paulssen, Ruth H; Leirvik, Jørn; VÅrtun, Åse; Acharya, Ganesh. Placental Gene Expression Profile in Intrauterine Growth Restriction Due to Placental Insufficiency. Reproductive Sciences 2009; Volum 16 (7). ISSN 1933-7191.s 701 - 711.s doi: 10.1177/1933719109334256.
  • Paulssen, Ruth H; Moe, Bjørn; Grønaas, Halvor; Ørbo, Anne. Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids 2008; Volum 73. ISSN 0039-128X.s 116 - 128.s doi: 10.1016/j.steroids.2007.09.010.
  • Sitras, Vasilis; Paulssen, Ruth H; Grønaas, Halvor; VÅrtun, Åse; Acharya, Ganesh. Gene expression profile in labouring and non-labouring human placenta near term. Molecular human reproduction 2008; Volum 14. ISSN 1360-9947.s 61 - 65.s doi: 10.1093/molehr/gam083.
  • Paulssen, Ruth H; Moe, Bjørn; Grønaas, Halvor; Ørbo, Anne. Gene expression in endometrial cancer cells (Ishikawa)after short time high exposure to progesterone. Steroids 2008; Volum 73 (1). ISSN 0039-128X.s 116 - 128.s doi: 10.1016/j.steroids.2007.09.010.
  • Paulssen, Ruth H; Olsen, Lotte; Sogn, Thea Charlotte. MagNa Pure Compact RNA Isolation Kit: Isolation of High-Quality Total RNA from a Broad Range of Sample Material. Biochemica 2006; Volum 2. ISSN 0946-1310.s 14 - 16.
  • Fraeyman, N.; Van Emmelo, J.; Paulssen, Ruth H; Vermis, K.. Desensitization of muscarinic receptors. Receptors and Channels 2004; Volum 10. ISSN 1060-6823.s 1 - 10.s doi: 10.1080/10606820490281175.
  • Brodin, E; Svensson, Birgit; Paulssen, Ruth H; Nordøy, Arne; Hansen, John Bjarne. Intravascular release and urinary excretion of tissue factor pathway inhibitor during heparin treatment. Journal of Laboratory and Clinical Medicine 2004; Volum 144 (5). ISSN 0022-2143.s 246 - 253.
  • Ilkaeva, Olga; Kinch, Lisa; Paulssen, Ruth H; Ross, Elliott. Mutations of the carboxyl terminal domain of phospholipase C-beta 1 delineate the dimer interface and a potential Galphaq interaction site. Journal of Biological Chemistry 2002; Volum 277. ISSN 0021-9258.s 4294 - 4300.
  • Thommesen, Liv; Hofsli, Eva; Paulssen, Ruth H; Anthonsen, Marit; Lærgreid, Astrid. Molecular Mechanisms involved in gastrin mediated regulation of cAMP-responsive (CRE) promotor element. American Journal of Physiology 2001; Volum 281. ISSN 0002-9513.s E1316 - E1325.
  • Johansen, Per Wiik; Paulssen, Ruth H; Bjøro, Trine; Gautvik, Kaare; Gordeladze, Jan. Distinct guanine nucleotide binding protein alpha-subunit receptor coupling in GH cell lines: Effects of bromocriptine and hormnones on effector enzyme modulation. Cellular Physiology and Biochemistry 2001; Volum 11. ISSN 1015-8987.s 339 - 352.
  • Johansen, Per Wiik; Paulssen, Ruth H; Bjøro, Trine; Gautvik, Kaare M; Gordeladze, Jan Oxholm. Distinct guanine nucleotide binding protein alpha-subunit receptor coupling in GH cell lines: effects of bromocriptine and hormones on effector enzyme modulation. Cellular Physiology and Biochemistry 2001; Volum 11 (6). ISSN 1015-8987.s 339 - 352.
  • Paulssen, Ruth H; Fraeyman, Norbert; Florholmen, Jon. Activation of phospholipase C by CCK receptor subtypes with different G protein-coupling specificities in hormone secreting pancreatic cell lines. Biochemical Pharmacology 2000; Volum 60. ISSN 0006-2952.s 865 - 875.
  • Gordeladze, Jan Oxholm; Haugen, T. B.; Paulssen, E. J.; Paulssen, R. H.. Phospholipase C activation in rat pituitary adenoma (GH) cells. Bioscience Reports 1996; Volum 16. ISSN 0144-8463.s 65 - 74.
  • Mortensen, Berit Marie; Lund, Hanne Wessel; Jablonski, Greg; Paulssen, Ruth H; Gordeladze, Jan Oxholm. Direct effects of vitamin D3 analogues on G-protein mediated signalling systems in rat osteosarcoma cells and rat pituitary adenoma cells. Bioscience Reports 1995; Volum 15 (3). ISSN 0144-8463.s 135 - 50.
  • Gordeladze, Jan Oxholm; Johansen, Per Wiik; Paulssen, Ruth H; Paulssen, Eyvind J; Gautvik, Kaare M. G-proteins: implications for pathophysiology and disease. European Journal of Endocrinology 1994; Volum 131 (6). ISSN 0804-4643.s 557 - 574.
  • Paulssen, Ruth H; Johansen, Per Wiik; Gordeladze, Jan Oxholm; Nymoen, Ole-Martin; Paulssen, Eyvind Jakob; Gautvik, Kaare M. Cell-specific expression and function of adenylyl cyclases in rat pitruitary tumour cell lines. European Journal of Biochemistry 1994; Volum 222 (1). ISSN 0014-2956.s 97 - 103.
  • Paulssen, Ruth H; Paulssen, Eyvind Jakob; Gautvik, Kaare M; Gordeladze, Jan Oxholm. Modulation of G proteins and second messenger responsiveness by steroid hormones in GH3 rat pituitary tumour cells. Acta Physiologica Scandinavica 1992; Volum 146 (2). ISSN 0001-6772.s 511 - 518.
  • Paulssen, Ruth H; Paulssen, Eyvind Jakob; Gautvik, Kaare M; Gordeladze, Jan Oxholm. The thyroliberin receptor interacts directly with a stimulatory guanine-nucleotide-binding protein in the activation of adenylyl cyclase in GH3 rat pituitary tumour cells. Evidence obtained by use of antisense RNA inhibition and immunoblocking of the stimulatory guanine-nucleotide-binding protein. European Journal of Biochemistry 1992; Volum 204 (1). ISSN 0014-2956.s 413 - 418.
  • Paulssen, Eyvind Jakob; Paulssen, Ruth H; Gautvik, Kaare M; Gordeladze, Jan Oxholm. Hypothalamic hormones modulate G protein levels and second messenger responsiveness in GH3 rat pituitary tumour cells. Biochemical Pharmacology 1992; Volum 44 (3). ISSN 0006-2952.s 471 - 477.
  • Paulssen, Eyvind Jakob; Paulssen, Ruth H; Gautvik, Kaare M; Gordeladze, Jan Oxholm. "Cross-talk" between phospholipase C and adenylyl cyclase involves regulation of G-protein levels in GH3 rat pituitary cells. Cellular Signalling 1992; Volum 4 (6). ISSN 0898-6568.s 747 - 755.
  • Paulssen, Ruth H; Paulssen, Eyvind Jakob; Gordeladze, Jan Oxholm; Hansson, Vidar; Haugen, Trine B.. Cell-specific expression of guanine nucleotide-binding proteins in rat testicular cells. Biology of Reproduction 1991; Volum 45 (4). ISSN 0006-3363.s 566 - 571.
  • Paulssen, Eyvind Jakob; Paulssen, Ruth H; Haugen, Trine B.; Gautvik, Kaare M; Gordeladze, Jan Oxholm. Regulation of G protein mRNA levels by thyroliberin, vasoactive intestinal peptide and somatostatin in prolactin-producing rat pituitary adenoma cells. Acta Physiologica Scandinavica 1991; Volum 143 (2). ISSN 0001-6772.s 195 - 201.
  • Paulssen, Eyvind Jakob; Paulssen, Ruth H; Haugen, Trine B.; Gautvik, Kaare M; Gordeladze, Jan Oxholm. Cell specific distribution of guanine nucleotide-binding regulatory proteins in rat pituitary tumour cell lines. Molecular and Cellular Endocrinology 1991; Volum 76 (1-3). ISSN 0303-7207.s 45 - 53.
  • Paulssen, Ruth H; Paulssen, Eyvind Jakob; Alestrøm, Peter; Gordeladze, Jan Oxholm; Gautvik, Kaare M. Specific antisense RNA inhibition of growth hormone production in differentiated rat pituitary tumour cells. Biochemical and Biophysical Research Communications - BBRC 1990; Volum 171 (1). ISSN 0006-291X.s 293 - 300.
  • Sitras, Vasilis; Fenton, Christopher Graham; Paulssen, Ruth H; VÅrtun, Åse; Acharya, Ganesh. GLOBAL PLACENTAL GENE EXPRESSION PROFILING IN THE FIRST AND THIRD TRIMESTERS OF NORMAL HUMAN PREGNANCY. Placenta 2011; Volum 32 (9). ISSN 0143-4004.s A136 - A136.
  • Sitras, Vasilis; Fenton, Christopher Graham; Paulssen, Ruth H; VÅrtun, Åse; Acharya, Ganesh. Global gene expression profiling in the first and third trimesters of normal human pregnancy. Placenta 2011; Volum 32 (9). ISSN 0143-4004.s A136 - .
  • Hellevik, Turid; Pettersen, Inger; Winberg, Jan-Olof; Berg, Vivian; Paulssen, Ruth H; Bartnes, Kristian; Busund, Lill-Tove; Bremnes, Roy M.; Martinez, Inigo Zubiavrre. The Impact of Ionizing Radiation on the Motility and Matrix Remodelling Properties of Carcinoma-associated Fibroblasts. European Journal of Cancer 2011; Volum 47. ISSN 0959-8049.s S142 - S143.
  • Lund, trine; Hals, Margareth Bergesen; Paulssen, Ruth H; Ytrehus, Kirsti. Increased gene expression diversity between female and male mice hearts after transverse aortic constriction (TAC). Regional forskningskonferanse innen medisin og helse 2009-03-25 - 2009-03-26 2009.
  • Lund, trine; Hals, Margareth Bergesen; Paulssen, Ruth H; Ytrehus, Kirsti. Increased gene expression diversity between female and male hearts after transverse aortic constriction (TAC). Heart Failure 2009-05-30 - 2009-06-02 2009.
  • Snipstad, Kristin; Fenton, Christopher Graham; Kjaeve, J; Kjæve, Jørn; Anderssen, Endre; Paulssen, Ruth H. New specific molecular targets for radiochemotherapy in colorectal cancer. The FEBS Journal 2009; Volum 276. ISSN 1742-464X.s 121 - 121.
  • Lund, trine; Hals, Margareth Bergesen; Paulssen, Ruth H; Ytrehus, Kirsti. Increased gene expression diversity between female and male hearts after transverse aortic constriction (TAC). European Journal of Heart Failure. Supplements 2009; Volum 8 (2). ISSN 1567-4215.
  • Olsen, Karina Standahl; Fenton, CG; Anderssen, Endre; Frøyland, Livar; Paulssen, RH; Lund, E. Associations between serum linolenic acid/alpha-linolenic acid ratio and blood gene expression profiles. The FEBS Journal 2009; Volum 276. ISSN 1742-464X.s 115 - 116.
  • Sitras, Vasilis; Paulssen, Ruth H; Grønaas, HS; Leirvik, Jørn; VÅrtun, Åse; Acharya, Ganesh. Differential Placental Gene Expression in Severe Preeclampsia. Gynekologen 2008; Volum 21 (3). ISSN 0805-2158.s 39 - .
  • Sitras, Vasilis; Paulssen, Ruth H; Grønaas, Halvor; VÅrtun, Åse; Acharya, Ganesh. Placental Gene Expression in Severe Preeclampsia. (Abstracts of the 20th European Congress of Obstetrics and Gynaecology). Acta Obstetrica Ginecologica Portuguesa 2008. ISSN 1646-5830.s 51 - 52.
  • Dumeaux, vanessa; Olsen, Karina Standahl; Leirvik, Jørn; Paulssen, Ruth H; Borresen-Dale, AL; Lund, Eiliv. Variation of gene expression profiles in whole blood from a large representative sample of postmenopausal Norwegian women. European Journal of Cancer 2008; Volum 6. ISSN 0959-8049.s 97 - 97.
  • Sitras, Vasilis; Paulssen, Ruth H; Grønaas, Halvor; Ganesh, Acharya. Gene expression profile in labouring and non-labouring placenta near term. American Journal of Obstetrics and Gynecology 2007; Volum 195. ISSN 0002-9378.
  • Paulssen, Ruth H; Moe, Bjørn; Grønaas, Halvor; Ørbo, Anne. Gene expression in endometrial cancer cells (ishikawa) after short time high dose exposure to progestins. Virchows Archiv 2007; Volum 451. ISSN 0945-6317.s 163 - 164.
  • Mortensen, Elin; Hansen, L; Bjurstam, Nils; Klenow, S; Frantzen, Jan-Ole; Paulssen, Ruth H. Imprint of core biopsies as a reliable diagnostic tool in breast cancer and possible usefullness for research purposes. Breast Cancer Research 2005; Volum 7. ISSN 1465-542X.s 33 - .
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