Engelsk personkortEngh, Richard Alan
Professor
Kjemi
Funksjon
Strukturkjemi, gruppeleder Norstruct
Telefon
776 44073
Epost
Kontor/besøksadresse
Forskningsparken 3
FPARK G 222
Foto: Ukjent
Arbeider i CRIStin
- Åberg, espen; Lund, Bjarte Aarmo; Pflug, Alexander; Gani, Osman A.B.S.M.; Rothweiler, Ulli; Oliveira, Taiana Maia De; Engh, Richard Alan. Structural origins of AGC protein kinase inhibitor selectivities: PKA as a drug discovery tool. Biological chemistry (Print) 2012; Volum 393 (10). ISSN 1431-6730.s 1121 - 1129.s doi: 10.1515/hsz-2012-0248.
- Østnes Hanssen, Kine; Andersen, Jeanette hammer; Stiberg, Trine; Engh, Richard Alan; Svenson, Johan; Genevière, Anne-Marie; Hansen, Espen. Antitumoral and Mechanistic Studies of Ianthelline Isolated from the Arctic Sponge Stryphnus fortis. Anticancer Research 2012; Volum 32 (10). ISSN 0250-7005.s 4287 - 4297.
- Pflug, Alexander; Johnson, Kenneth; Engh, Richard Alan. Anomalous dispersion analysis of inhibitor flexibility: a case study of the kinase inhibitor H-89. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2012; Volum 68. ISSN 1744-3091.s 873 - 877.s doi: 10.1107/S1744309112028655.
- Pflug, Alexander; Oliveira, Taiana Maia De; Bossemeyer, Dirk; Engh, Richard Alan. Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase. Biochemical Journal 2011; Volum 440. ISSN 0264-6021.s 85 - 93.s doi: 10.1042/BJ20110592.
- Oliveira, Taiana Maia De; Ahmad, Rafi; Engh, Richard Alan. VX680 Binding in Aurora A: pi-pi Interactions Involving the Conserved Aromatic Amino Acid of the Flexible Glycine-Rich Loop. Journal of Physical Chemistry A 2011; Volum 115 (16). ISSN 1089-5639.s 3895 - 3904.s doi: 10.1021/jp108286r.
- von Bubnoff, N.; Gorantla, S.P.; Engh, Richard Alan; Oliveira, Taiana Maia De; Thöne, S.; Åberg, espen; Peschel, C.; Duyster, J.. The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro. Oncogene 2011; Volum 30 (8). ISSN 0950-9232.s 933 - 943.s doi: 10.1038/onc.2010.476.
- Rothweiler, Ulli; Åberg, espen; Johnson, Kenneth; Hansen, Tom Egil; Jørgensen, Jorunn B; Engh, Richard Alan. p38 alpha MAP Kinase Dimers with Swapped Activation Segments and a Novel Catalytic Loop Conformation. Journal of Molecular Biology 2011; Volum 411 (2). ISSN 0022-2836.s 474 - 485.s doi: 10.1016/j.jmb.2011.06.013.
- Prime, ME; Courtney, SM; Brookfield, FA; Marston, RW; Walker, V; Warne, J; Boyd, AE; Kairies, NA; Von der Saal, W; Limberg, A; Georges, G; Engh, Richard Alan; Goller, B; Rueger, P; Rueth, M. Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase. Journal of Medicinal Chemistry 2011; Volum 54 (1). ISSN 0022-2623.s 312 - 319.s doi: 10.1021/jm101346r.
- Pflug, Alexander; Rogozina, Jevgenia; Lavogina, Darja; Enkvist, Erki; Uri, Asko; Engh, Richard Alan; Bossemeyer, Dirk. Diversity of Bisubstrate Binding Modes of Adenosine Analogue-Oligoarginine Conjugates in Protein Kinase A and Implications for Protein Substrate Interactions. Journal of Molecular Biology 2010; Volum 403 (1). ISSN 0022-2836.s 66 - 77.s doi: 10.1016/j.jmb.2010.08.028.
- Gani, Osman A.B.S.M.; Engh, Richard Alan. Protein kinase inhibition of clinically important staurosporine analogues. Natural product reports (Print) 2010; Volum 27 (4). ISSN 0265-0568.s 489 - 498.s doi: 10.1039/b923848b.
- von Bubnoff, N; Engh, Richard Alan; Åberg, espen; Sanger, J; Peschel, C; Duyster, J. FMS-Like Tyrosine Kinase 3-Internal Tandem Duplication Tyrosine Kinase Inhibitors Display a Nonoverlapping Profile of Resistance Mutations In vitro. Cancer Research 2009; Volum 69 (7). ISSN 0008-5472.s 3032 - 3041.s doi: 10.1158/0008-5472.CAN-08-2923.
- Engh, Richard Alan. Protein kinase inhibitors highlight the complexities of drug-target non-covalent interactions. Biotechnology & Biotechnological Equipment (Sofia) 2008; Volum 22. ISSN 1310-2818.s 772 - 777.
- Gruber, Franz; Ernst, Thomas; Porkka, Kimmo; Engh, Richard Alan; Mikkola, ingvild; Maier, Jacqueline; Lange, Thoralf; Hochhaus, Andreas. Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients. Leukemia 2012; Volum 26 (1). ISSN 0887-6924.s 172 - 177.s doi: 10.1038/leu.2011.187.
- Kancha, RK; von Bubnoff, N; Bartosch, N; Peschel, C; Engh, Richard Alan; Duyster, J. Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. PLoS ONE 2011; Volum 6(10):e26760. ISSN 1932-6203.s doi: 10.1371/journal.pone.0026760.
